Lipid based nanocarriers for effective drug delivery and treatment of diabetes associated liver fibrosis

Liver-Targeted siRNA Lipid Nanoparticles Treat Hepatic Cirrhosis by Dual Antifibrotic and Anti-inflammatory Activities

(2020) Jinfang Zhang et al.   ACS Nano

Hyperbranched lipoid-based lipid nanoparticles for bidirectional regulation of collagen accumulation in liver fibrosis

(2020) Jian-Bin Qiao et al.   JOURNAL OF CONTROLLED RELEASE

Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles

(2020) Kejin Zhou et al.   MOLECULAR PHARMACEUTICS

Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease

(2020) Marius Maximilian Woitok et al.   Cell Death & Disease

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?

(2020) Yau-Tuen Chan et al.   Frontiers in Pharmacology

Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives

(2020) Somayeh Mahdinloo et al.   Acta Pharmaceutica Sinica B

Lipid-based nanoparticle technologies for liver targeting

(2020) Roland Böttger et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid nanoparticle technology for therapeutic gene regulation in the liver

(2020) Dominik Witzigmann et al.   ADVANCED DRUG DELIVERY REVIEWS

Pathobiological and molecular connections involved in the high fructose and high fat diet induced diabetes associated nonalcoholic fatty liver disease

(2020) Ekta et al.   INFLAMMATION RESEARCH

Golgi Apparatus-Targeted Chondroitin-Modified Nanomicelles Suppress Hepatic Stellate Cell Activation for the Management of Liver Fibrosis

(2019) Jingwen Luo et al.   ACS Nano

Human serum albumin-based probes for molecular targeting of macrophage scavenger receptors

(2019) Mona Ahmed et al.   International Journal of Nanomedicine

CXCR4-targeted liposomal mediated co-delivery of pirfenidone and AMD3100 for the treatment of TGFβ-induced HSC-T6 cells activation

(2019) Aftab Ullah et al.   International Journal of Nanomedicine

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

(2019) Beatriz García-Pinel et al.   Nanomaterials

An integrin-based nanoparticle that targets activated hepatic stellate cells and alleviates liver fibrosis

(2019) Yanping Li et al.   JOURNAL OF CONTROLLED RELEASE

Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier

(2019) Vedanti R. Salvi et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Traditional Chinese medicine combined with hepatic targeted drug delivery systems: A new strategy for the treatment of liver diseases

(2019) Zhe Ma et al.   BIOMEDICINE & PHARMACOTHERAPY

Nanoparticle Delivery Systems in the Treatment of Diabetes Complications

(2019) Eliana B. Souto et al.   MOLECULES

Preparation and evaluation of PEGylated asiatic acid nanostructured lipid carriers on anti-fibrosis effects

(2019) Xiaoxiao Chen et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Albumin self-modified liposomes for hepatic fibrosis therapy via SPARC-dependent pathways

(2019) Jianzhu Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes

(2018) Regina Tavano et al.   ACS Nano

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis

(2018) Qiaozhu Su et al.   ADVANCED DRUG DELIVERY REVIEWS

Vitamin A-coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis

(2018) Hirotaka Furuhashi et al.   HEPATOLOGY RESEARCH

Clinical phase 1b study results for safety, pharmacokinetics and efficacy of ND-L02-s0201, a novel targeted lipid nanoparticle delivering HSP47 SIRNA for the treatment of Japanese patients with advanced liver fibrosis

(2018) N. Sakamoto et al.   JOURNAL OF HEPATOLOGY

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

Self-assembly and directed assembly of lipid nanocarriers for prevention of liver fibrosis in obese rats: a comparison with the therapy of bariatric surgery

(2018) Chun-Han Chen et al.   Nanomedicine

Lipid based nanocarriers: a translational perspective

(2018) Dinesh K. Mishra et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement

(2018) Frédéric Brioude et al.   Nature Reviews Endocrinology

Anti-inflammatory properties of ursodeoxycholyl lysophosphatidylethanolamide in endotoxin-mediated inflammatory liver injury

(2018) Johannes Maximilian Ludwig et al.   PLoS One

Nanoparticulate-based drug delivery systems for small molecule anti-diabetic drugs: an emerging paradigm for effective therapy

(2018) Siddharth Uppal et al.   Acta Biomaterialia

Gene-silencing technology gets first drug approval after 20-year wait

(2018) Heidi Ledford   NATURE

Chemically modified liposomes carrying TRAIL target activated hepatic stellate cells and ameliorate hepatic fibrosis in vitro and in vivo

(2018) Qinghua Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

pPB Peptide-Mediated siRNA-Loaded Stable Nucleic Acid Lipid Nanoparticles on Targeting Therapy of Hepatic Fibrosis

(2017) Zongxiang Jia et al.   MOLECULAR PHARMACEUTICS

Lipid–Drug Conjugate for Enhancing Drug Delivery

(2017) Danielle Irby et al.   MOLECULAR PHARMACEUTICS

A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A

(2017) Müjdat Zeybel et al.   MOLECULAR THERAPY

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis

(2017) Zhenzhen Li et al.   NEPHROLOGY

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology

(2017) Arun Richard Chandrasekaran et al.   NUCLEIC ACIDS RESEARCH

Self-Nanoemulsifying Drug Delivery System of Coenzyme (Q10) with Improved Dissolution, Bioavailability, and Protective Efficiency on Liver Fibrosis

(2016) Abeer Khattab et al.   AAPS PHARMSCITECH

“Eat me” imaging and therapy

(2016) Vaishali Bagalkot et al.   ADVANCED DRUG DELIVERY REVIEWS

Lipid Nanoparticles and their Application in Nanomedicine

(2016) Mehdi Rajabi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems

(2016) Jafar Ezzati Nazhad Dolatabadi et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells

(2015) Wei Rao et al.   ACS Nano

DSPE-PEG: A Distinctive Component in Drug Delivery System

(2015) Jing Che et al.   CURRENT PHARMACEUTICAL DESIGN

Clinical Model for NASH and Advanced Fibrosis in Adult Patients With Diabetes and NAFLD: Guidelines for Referral in NAFLD

(2015) Jessica Bazick et al.   DIABETES CARE

Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis

(2015) Carolina Jiménez Calvente et al.   HEPATOLOGY

Berberine-loaded solid lipid nanoparticles are concentrated in the liver and ameliorate hepatosteatosis in db/db mice

(2015) Mei Xue et al.   International Journal of Nanomedicine

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials-Science & Engineering

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials Science & Engineering

A review on phospholipids and their main applications in drug delivery systems

(2015) Jing Li et al.   Asian Journal of Pharmaceutical Sciences

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A

(2014) Y. Wan et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

The Fatty Acid–Bile Acid Conjugate Aramchol Reduces Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

(2014) Rifaat Safadi et al.   Clinical Gastroenterology and Hepatology

Designer lipids for drug delivery: From heads to tails

(2014) Aditya G. Kohli et al.   JOURNAL OF CONTROLLED RELEASE

‘Stealth’ lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug

(2014) Orlagh M. Feeney et al.   JOURNAL OF CONTROLLED RELEASE

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Fetuin-A negatively correlates with liver and vascular fibrosis in nonalcoholic fatty liver disease subjects

(2014) Motoya Sato et al.   LIVER INTERNATIONAL

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nanoparticles as drug delivery systems

(2014) Agnieszka Z. Wilczewska et al.   Pharmacological Reports

Nanotechnology applications for the therapy of liver fibrosis

(2014) Lydia Giannitrapani   WORLD JOURNAL OF GASTROENTEROLOGY

Hyaluronic acid–siRNA conjugates complexed with cationic solid lipid nanoparticles for target specific gene silencing

(2014) Min-Young Lee et al.   RSC Advances

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

TGF-β1 Up-Regulates the Expression of PDGF-β Receptor mRNA and Induces a Delayed PI3K-, AKT-, and p70S6K-Dependent Proliferative Response in Activated Hepatic Stellate Cells

(2013) Ruchi Shah et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

An increase in theAkkermansiaspp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

(2013) Na-Ri Shin et al.   GUT

Comparing different sterol containing solid lipid nanoparticles for targeted delivery of quercetin in hepatocellular carcinoma

(2013) Jaleh Varshosaz et al.   JOURNAL OF LIPOSOME RESEARCH

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Clinical Indications for Plerixafor

(2013) Stefan Fruehauf   TRANSFUSION MEDICINE AND HEMOTHERAPY

Lipid nanoparticle delivery systems for siRNA-based therapeutics

(2013) C. Wan et al.   Drug Delivery and Translational Research

Cationic solid lipid nanoparticles derived from apolipoprotein-free LDLs for target specific systemic treatment of liver fibrosis

(2012) Won Ho Kong et al.   BIOMATERIALS

Lipid nanoparticles: state of the art, new preparation methods and challenges in drug delivery

(2012) Luigi Battaglia et al.   Expert Opinion on Drug Delivery

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Oxymatrine liposome attenuates hepatic fibrosisviatargeting hepatic stellate cells

(2012) Ning-Li Chai   WORLD JOURNAL OF GASTROENTEROLOGY

Target-Specific Gene Silencing of Layer-by-Layer Assembled Gold–Cysteamine/siRNA/PEI/HA Nanocomplex

(2011) Min-Young Lee et al.   ACS Nano

Mammalian target of rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells

(2011) Sara Aleffi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Nonalcoholic fatty liver disease

(2011) Marcin Krawczyk et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Localized, Targeted, and Sustained siRNA Delivery

(2011) Melissa D. Krebs et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hepatoprotective and neuroprotective activity of liposomal quercetin in combating chronic arsenic induced oxidative damage in liver and brain of rats

(2011) Aparajita Ghosh et al.   DRUG DELIVERY

Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies

(2011) John Willy Haukeland et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Lipid nanoparticle siRNA systems for silencing the androgen receptor in human prostate cancer in vivo

(2011) Justin B. Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Insulin resistance in nonalcoholic steatohepatitis: necessary but not sufficient – death of a dogma from analysis of therapeutic studies?

(2011) Amedeo Lonardo et al.   Expert Review of Gastroenterology & Hepatology

Triplex forming oligonucleotides against type α1(I) collagen attenuates liver fibrosis induced by bile duct ligation

(2010) Ravikiran Panakanti et al.   BIOCHEMICAL PHARMACOLOGY

Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats

(2010) Arvindkumar E. Ghule et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor

(2010) Li Chen et al.   JOURNAL OF HEPATOLOGY

Polymer- and lipid-based nanoparticle therapeutics for the treatment of liver diseases

(2010) Lanjuan Li et al.   Nano Today

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Functions of coenzyme Q10in inflammation and gene expression

(2009) Constance Schmelzer et al.   BIOFACTORS

Solid lipid nanoparticles for applications in gene therapy: a review of the state of the art

(2009) Maria Luisa Bondì et al.   Expert Opinion on Drug Delivery

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Adipokines in liver diseases

(2009) Fabio Marra et al.   HEPATOLOGY

Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system

(2009) Su-Jin Cheong et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems

(2009) Prabagar Balakrishnan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cytokines and Renin-Angiotensin System Signaling in Hepatic Fibrosis

(2008) Montserrat Moreno et al.   Clinics in Liver Disease

High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase

(2008) Masayuki Adachi et al.   HEPATOLOGY

Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride

(2008) Ogyi Park et al.   HEPATOLOGY

Cationic Solid Lipid Nanoparticles Reconstituted from Low Density Lipoprotein Components for Delivery of siRNA

(2008) Hyun Ryoung Kim et al.   MOLECULAR PHARMACEUTICS

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

(2008) Janice Jou et al.   SEMINARS IN LIVER DISEASE

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers – Innovative Generations of Solid Lipid Carriers

(2008) S. Shidhaye et al.   Current Drug Delivery

Berberine improves glucose metabolism through induction of glycolysis

(2007) Jun Yin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM