Article
Medicine, Research & Experimental
Hiroki Sakamoto, Yu-ichiro Koma, Nobuhide Higashino, Takayuki Kodama, Kohei Tanigawa, Masaki Shimizu, Masataka Fujikawa, Mari Nishio, Manabu Shigeoka, Yoshihiro Kakeji, Hiroshi Yokozaki
Summary: The study reveals that PAI-1 derived from cancer-associated fibroblasts promotes invasion of esophageal squamous cell carcinoma cells and migration of macrophages through LRP1. High expression of PAI-1 and/or LRP1 is associated with poor prognosis in ESCC patients, suggesting PAI-1/LRP1 axis could be a potential target for cancer therapy.
LABORATORY INVESTIGATION
(2021)
Article
Immunology
Florence Jeny, Jean-Francois Bernaudin, Dominique Valeyre, Marianne Kambouchner, Marina Pretolani, Hilario Nunes, Carole Planes, Valerie Besnard
Summary: Hypoxia has a significant impact on MD-macrophages from sarcoidosis patients, inducing proinflammatory and profibrotic responses while reducing antigen presentation, potentially leading to deficient T cell response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yong-Han Su, Yi-Zhen Wu, David K. K. Ann, Jenny Ling-Yu Chen, Ching-Ying Kuo
Summary: Obesity is a risk factor for various cancers, including breast cancer. Adipose tissue disturbance in obesity is closely related to cancer progression and resistance to standard treatments. In this study, diet-induced obesity promoted tumor growth and reduced tumor response to radiotherapy in the mouse model of triple-negative breast cancer. Serpine1 was found to be elevated in the blood of obese mice and enriched in the tumor microenvironment.
CELL DEATH & DISEASE
(2023)
Article
Medicine, Research & Experimental
Florence Boissiere-Michot, Caroline Mollevi, Volker Baecker, Evelyne Crapez, William Jacot
Summary: Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) have been identified as prognostic and predictive biomarkers in breast cancer, but their clinical use is limited due to the need for fresh-frozen or fresh tumor samples for quantification. This study compared the expression levels of PLAU and SERPINE1 mRNA (corresponding to uPA and PAI-1 proteins) using in situ hybridization with immunometric assay in breast tumor samples. The results showed that in situ hybridization cannot replace the immunometric assay for quantification of uPA and PAI-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Ke-Fan Pan, Yu-Cheng Liu, Michael Hsiao, Tsu-Yao Cheng, Kuo-Tai Hua
Summary: Naa10p plays an oncogenic role in promoting esophageal cancer metastasis, with higher expression correlating with poorer patient survival. Transcription of NAA10 is regulated by the critical oncogene c-Myc. The enzymatic activity of Naa10p, along with Naa15p, inhibits the secretion of the protease inhibitor PAI1. These findings establish the significance of Naa10p in driving metastasis in esophageal cancer, suggesting its potential use as a prognostic biomarker and therapeutic target.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Shuhai Chen, Yuji Morine, Kazunori Tokuda, Shinichiro Yamada, Yu Saito, Masaaki Nishi, Tetsuya Ikemoto, Mitsuo Shimada
Summary: This study found that in hepatocellular carcinoma, CAFs promote M2 polarization of TAMs and induce secretion of PAI-1 via CXCL12, enhancing the malignant behavior of HCC cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ashna A. Kumar, Benjamin J. Buckley, Marie Ranson
Summary: This review provides an overview of the role of the urokinase plasminogen activation system (uPAS) in pancreatic cancer, with a focus on pancreatic ductal adenocarcinoma (PDAC), and summarizes the substantial evidence supporting the role of uPAS components in this disease. The review further outlines the potential clinical utility of uPAS components as diagnostic and prognostic biomarkers for PDAC, as well as the rationale for developing novel uPAS-targeted therapeutics.
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Esra Demirel, Reem Sabouni, Neelima Chandra, Ov D. Slayden, David F. Archer
Summary: The study investigates the distribution and concentrations of several receptors and activators within the primate endometrium during artificial menstrual cycles, showing similarities in their expression patterns suggesting overlapping pathways. These findings indicate potential interactions between the plasminogen activator system and steroid receptors in the endometrium.
REPRODUCTIVE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yaowu Qin, Jing Zhang, Savalan Babapoor-Farrokhran, Brooks Applewhite, Monika Deshpande, Haley Megarity, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Tao Ma, Yuan Rui, Stephany Y. Tzeng, Jordan J. Green, M. Valeria Canto-Soler, Silvia Montaner, Akrit Sodhi
Summary: For patients with proliferative diabetic retinopathy (PDR) who do not respond adequately to pan-retinal laser photocoagulation (PRP) or anti-vascular endothelial growth factor (VEGF) therapies, targeting the HIF-2 alpha/PAI-1 axis may be an effective adjunct therapy for the treatment of PDR patients.
Article
Oncology
Veronica Lifshitz, Saul J. Priceman, Wenzhao Li, Gregory Cherryholmes, Heehyoung Lee, Adar Makovski-Silverstein, Lucia Borriello, Yves A. DeClerck, Hua Yu
MOLECULAR CANCER THERAPEUTICS
(2017)
Article
Oncology
Michael D. Hadjidaniel, Sakunthala Muthugounder, Long T. Hung, Michael A. Sheard, Soheila Shirinbak, Randall Y. Chan, Rie Nakata, Lucia Borriello, Jemily Malvar, Rebekah J. Kennedy, Hiroshi Iwakura, Takashi Akamizu, Richard Sposto, Hiroyuki Shimada, Yves A. DeClerck, Shahab Asgharzadeh
Article
Multidisciplinary Sciences
Jingying Xu, Xiuhai Ren, Anup Singh Pathania, G. Esteban Fernandez, Anthony Tran, Yifu Zhang, Rex A. Moats, Gregory M. Shackleford, Anat Erdreich-Epstein
SCIENTIFIC REPORTS
(2017)
Article
Environmental Sciences
Stephanie Ly, Madeleine L. Burg, Ugonna Ihenacho, Frederick Brindopke, Allyn Auslander, Kathleen S. Magee, Pedro A. Sanchez-Lara, Thi-Hai-Duc Nguyen, Viet Nguyen, Maria Irene Tangco, Angela Rose Hernandez, Melissa Giron, Fouzia J. Mahmoudi, Yves A. DeClerck, William P. Magee, Jane C. Figueiredo
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2017)
Article
Biology
Danielle V. Bower, Nick Lansdale, Sonia Navarro, Thai V. Truong, Dan J. Bower, Neil C. Featherstone, Marilyn G. Connell, Denise Al Alam, Mark R. Frey, Le A. Trinh, G. Esteban Fernandez, David Warburton, Scott E. Fraser, Daimark Bennett, Edwin C. Jesudason
Article
Multidisciplinary Sciences
Marta H. Kubala, Yves A. DeClerck
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Multidisciplinary Sciences
Yongfeng Luo, Nan Li, Hui Chen, G. Esteban Fernandez, David Warburton, Rex Moats, Robert P. Mecham, Daria Krenitsky, Gloria S. Pryhuber, Wei Shi
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Hong-Wei Wu, Michael A. Sheard, Jemily Malvar, G. Esteban Fernandez, Yves A. DeClerck, Laurence Blavier, Hiroyuki Shimada, Charles P. Theuer, Richard Sposto, Robert C. Seeger
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemical Research Methods
Joycelyn K. Yip, Michael Harrison, Jessi Villafuerte, G. Esteban Fernandez, Andrew P. Petersen, Ching-Ling Lien, Megan L. Mccain
Article
Oncology
Lucia Borriello, Rie Nakata, Michael A. Sheard, G. Esteban Fernandez, Richard Sposto, Jemily Malvar, Laurence Blavier, Hiroyuki Shimada, Shahab Asgharzadeh, Robert C. Seeger, Yves A. DeClerck
Article
Cell Biology
Rie Nakata, Hiroyuki Shimada, Esteban Fernandez, Rob Fanter, Muller Fabbri, Jemily Malvar, Pascale Zimmermann, Yves A. DeClerck
JOURNAL OF EXTRACELLULAR VESICLES
(2017)
Article
Oncology
Yves A. DeClerck, Kenneth J. Pienta, Elisa C. Woodhouse, Dinah S. Singer, Suresh Mohla