Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
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Title
Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
Authors
Keywords
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Journal
ACS Chemical Neuroscience
Volume 12, Issue 11, Pages 2057-2068
Publisher
American Chemical Society (ACS)
Online
2021-05-22
DOI
10.1021/acschemneuro.1c00235
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Note: Only part of the references are listed.- AMYLOID-β AND TAU AGGREGATION DUAL-INHIBITORS: A SYNTHETIC AND STRUCTURE-ACTIVITY RELATIONSHIP FOCUSED REVIEW
- (2021) Daniela Malafaia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Deciphering the Disaggregation Mechanism of Amyloid Beta Aggregate by 4-(2-Hydroxyethyl)-1-Piperazinepropanesulfonic Acid Using Electrochemical Impedance Spectroscopy
- (2021) Hien T. Ngoc Le et al. SENSORS
- Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis
- (2021) Phuong H. Nguyen et al. CHEMICAL REVIEWS
- Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial
- (2021) Yuji Koriyama et al. JOURNAL OF MEDICINAL CHEMISTRY
- Disaggregation mechanism of prion amyloid for tweezer inhibitor
- (2021) Mueed Ur Rahman et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- The β-secretase BACE1 in Alzheimer’s disease
- (2020) Harald Hampel et al. BIOLOGICAL PSYCHIATRY
- Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains
- (2020) Tamta Arakhamia et al. CELL
- Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6
- (2020) F. Javier Pérez-Areales et al. JOURNAL OF MEDICINAL CHEMISTRY
- Treatment Combinations for Alzheimer’s Disease: Current And Future Pharmacotherapy Options
- (2019) Jeffrey L. Cummings et al. JOURNAL OF ALZHEIMERS DISEASE
- Harnessing Polypharmacology with Medicinal Chemistry
- (2019) Maria Laura Bolognesi ACS Medicinal Chemistry Letters
- A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment
- (2019) Brati Das et al. CNS DRUGS
- Bacterial Inclusion Bodies for Anti-Amyloid Drug Discovery: Current and Future Screening Methods
- (2019) Ana B. Caballero et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease
- (2019) David Henley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Current and emerging avenues for Alzheimer's disease drug targets
- (2019) R. Loera‐Valencia et al. JOURNAL OF INTERNAL MEDICINE
- Investigational BACE inhibitors for the treatment of Alzheimer’s disease
- (2019) Bruno P. Imbimbo et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease
- (2019) Tomasz Wichur et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer’s Agents
- (2018) Dawid Panek et al. ACS Chemical Neuroscience
- A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia
- (2018) Ruth Knight et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Multifactorial Hypothesis and Multi-Targets for Alzheimer’s Disease
- (2018) Cheng-Xin Gong et al. JOURNAL OF ALZHEIMERS DISEASE
- Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation
- (2018) Peng Lv et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein–huprine hybrids
- (2017) Francisco Javier Pérez-Areales et al. Future Medicinal Chemistry
- PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8
- (2017) Michiaki Okuda et al. JOURNAL OF ALZHEIMERS DISEASE
- The BACE1 inhibitor verubecestat (MK-8931) reduces CNS -amyloid in animal models and in Alzheimers disease patients
- (2016) M. E. Kennedy et al. Science Translational Medicine
- Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs
- (2016) Alba Espargaró et al. Scientific Reports
- Study of early stages of amyloid Aβ13-23 formation using molecular dynamics simulation in implicit environments
- (2015) Marek Bajda et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques
- (2015) Hye Yun Kim et al. Nature Communications
- In vitro fibrillization of Alzheimer’s amyloid-β peptide (1-42)
- (2015) Ann Tiiman et al. AIP Advances
- Thioflavin-S Staining of Bacterial Inclusion Bodies for the Fast, Simple, and Inexpensive Screening of Amyloid Aggregation Inhibitors
- (2014) S. Pouplana et al. CURRENT MEDICINAL CHEMISTRY
- Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies
- (2014) Ornella Di Pietro et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Disaggregation Ability of Different Chelating Molecules on Copper Ion-Triggered Amyloid Fibers
- (2014) Linyi Zhu et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Bacterial Inclusion Bodies of Alzheimer's Disease β-Amyloid Peptides Can Be Employed To Study Native-Like Aggregation Intermediate States
- (2011) Muralidhar Dasari et al. CHEMBIOCHEM
- Biological role of bacterial inclusion bodies: a model for amyloid aggregation
- (2011) Elena García-Fruitós et al. FEBS Journal
- Protein folding and aggregation in bacteria
- (2010) Raimon Sabate et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Multi-Target-Directed Ligands To Combat Neurodegenerative Diseases
- (2008) Andrea Cavalli et al. JOURNAL OF MEDICINAL CHEMISTRY
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