Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein–huprine hybrids

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease

(2017) Jacques Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

(2017) Ziwei Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

(2017) Dawid Panek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti - β -amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease

(2017) Yan Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

(2017) Jakub Jeřábek et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

(2017) Sergey O. Bachurin et al.   MEDICINAL RESEARCH REVIEWS

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

(2017) Ornella Di Pietro et al.   PLoS One

Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in A?PPswe/PS-1 Mice of Different Ages

(2016) Felipe G. Serrano et al.   Current Alzheimer Research

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

(2016) Alba Espargaró et al.   Scientific Reports

Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway

(2016) Yang Wang et al.   Scientific Reports

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

(2015) Irene Sola et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

(2015) Christophe Rochais et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

(2015) Frederik J. R. Rombouts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

(2015) Xiaoming Zha et al.   JOURNAL OF MEDICINAL CHEMISTRY

CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure

(2015) Zoran Rankovic   JOURNAL OF MEDICINAL CHEMISTRY

Reactive oxygen species: friend or foe?

(2015) Arun Kumar Sharma et al.   RSC Advances

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

(2014) F. Javier Pérez-Areales et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Tacrine-Grafted Ugi Adducts as Multipotent Anti-Alzheimer Drugs: A Synthetic Renewal in Tacrine-Ferulic Acid Hybrids

(2014) Mohamed Benchekroun et al.   ChemMedChem

Thioflavin-S Staining of Bacterial Inclusion Bodies for the Fast, Simple, and Inexpensive Screening of Amyloid Aggregation Inhibitors

(2014) S. Pouplana et al.   CURRENT MEDICINAL CHEMISTRY

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

(2014) Ornella Di Pietro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A comprehensive study on the phenolic profile of widely used culinary herbs and spices: Rosemary, thyme, oregano, cinnamon, cumin and bay

(2014) Anna Vallverdú-Queralt et al.   FOOD CHEMISTRY

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies

(2013) Ornella Di Pietro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?

(2013) Michela Rosini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel tacrine–rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease

(2013) Su-Yi Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

(2013) Xiaojie Zhang et al.   Alzheimers Research & Therapy

Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction

(2012) Montserrat Soler-López et al.   BIOESSAYS

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

(2012) Stefano Rizzo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity

(2012) Tobias Ginman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

(2011) Carles Galdeano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure–activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

(2009) Cyril Ronco et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Designing Multiple Ligands – Medicinal Chemistry Strategies and Challenges

(2009) Richard Morphy et al.   CURRENT PHARMACEUTICAL DESIGN

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calculation of Solvation Free Energies of Charged Solutes Using Mixed Cluster/Continuum Models

(2008) Vyacheslav S. Bryantsev et al.   JOURNAL OF PHYSICAL CHEMISTRY B