AMYLOID-β AND TAU AGGREGATION DUAL-INHIBITORS: A SYNTHETIC AND STRUCTURE-ACTIVITY RELATIONSHIP FOCUSED REVIEW

Non-polyphenolic natural inhibitors of amyloid aggregation

(2020) Liang Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Perspective on Multi-target Drugs for Alzheimer’s Disease

(2020) Ondrej Benek et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease

(2019) Tao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms

(2019) Junting Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease

(2019) Nour M. Moussa‐Pacha et al.   MEDICINAL RESEARCH REVIEWS

Multi-target design strategies for the improved treatment of Alzheimer's disease

(2019) Pengfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease

(2019) Francesco Mesiti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological applications of near infrared fluorescence dye probes in monitoring Alzheimer’s disease

(2019) Yusif Issahak Gyasi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

(2019) Eleanor K. Pickett et al.   Cell Reports

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity

(2018) Juan Cen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease

(2018) Fuyuki Kametani et al.   Frontiers in Neuroscience

Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation

(2018) Peng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

(2018) Qi Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecules of the Quinoline Family Block Tau Self-Aggregation: Implications Toward a Therapeutic Approach for Alzheimer's Disease

(2018) Leonardo P. Navarrete et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction of Cinnamaldehyde and Epicatechin with Tau: Implications of Beneficial Effects in Modulating Alzheimer's Disease Pathogenesis

(2018) Roshni C. George et al.   JOURNAL OF ALZHEIMERS DISEASE

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Reconsideration of Anticholinesterase Therapeutic Strategies against Alzheimer’s Disease

(2018) Huan Wang et al.   ACS Chemical Neuroscience

Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo

(2018) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

The therapeutic potential of curcumin: A review of clinical trials

(2018) Bahare Salehi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of 2-arylethenyl- N -methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment

(2017) Chun-Li Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

(2017) Marie Jouanne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

(2017) Bilqees Sameem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein–huprine hybrids

(2017) Francisco Javier Pérez-Areales et al.   Future Medicinal Chemistry

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Design and synthesis of curcumin derivatives as tau and amyloid β dual aggregation inhibitors

(2016) Michiaki Okuda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment

(2016) Leide dos Santos Picanç et al.   CURRENT MEDICINAL CHEMISTRY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug

(2016) Rebecca E. Hughes et al.   Frontiers in Neuroscience

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

(2015) Irene Sola et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

(2014) F. Javier Pérez-Areales et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure and Mechanism of Action of Tau Aggregation Inhibitors

(2014) Katryna Cisek et al.   Current Alzheimer Research

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

(2014) Kris Simone Tranches Dias et al.   Current Neuropharmacology

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies

(2014) Ornella Di Pietro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

(2014) Elisabet Viayna et al.   JOURNAL OF MEDICINAL CHEMISTRY

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Progress and Developments in Tau Aggregation Inhibitors for Alzheimer Disease

(2013) Bruno Bulic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer disease therapy—moving from amyloid-β to tau

(2013) Ezio Giacobini et al.   Nature Reviews Neurology

A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer’s and Prion Diseases

(2012) Matteo Staderini et al.   ACS Medicinal Chemistry Letters

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biological markers of amyloid β-related mechanisms in Alzheimer's disease

(2009) Harald Hampel et al.   EXPERIMENTAL NEUROLOGY

Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment

(2008) Oskar Hansson et al.   NEUROBIOLOGY OF AGING

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

(2007) Rajeshwar Narlawar et al.   ChemMedChem