Schaftoside Suppresses Pentylenetetrazol-Induced Seizures in Zebrafish via Suppressing Apoptosis, Modulating Inflammation, and Oxidative Stress

Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: Magnolia officinalis Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model

(2020) Jing Li et al.   ACS Chemical Neuroscience

Activation of FXR by schaftoside ameliorates APAP-induced hepatotoxicity by modulating oxidative stress and inflammation

(2020) Meijing Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish

(2020) Baoyue Zhang et al.   Journal of Neuroimmune Pharmacology

Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish

(2020) Yam Nath Paudel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish

(2020) Xueliang Shang et al.   TOXICOLOGY LETTERS

Modeling Parkinson’s Disease in Zebrafish

(2020) Nor Haliza Mohamad Najib et al.   CNS & Neurological Disorders-Drug Targets

Zebrafish model of posttraumatic epilepsy

(2020) Sung‐Joon Cho et al.   EPILEPSIA

Increased ACh-Associated Immunoreactivity in Autonomic Centers in PTZ Kindling Model of Epilepsy

(2020) Enes Akyüz et al.   Biomedicines

Neuron–glia interactions in the pathophysiology of epilepsy

(2019) Dipan C. Patel et al.   NATURE REVIEWS NEUROSCIENCE

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

Early α-linolenic acid exposure to embryo reduces pentylenetetrazol-induced seizures in zebrafish larva

(2019) Savita Kumari et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Embelin Prevents Seizure and Associated Cognitive Impairments in a Pentylenetetrazole-Induced Kindling Zebrafish Model

(2019) Uday Praful Kundap et al.   Frontiers in Pharmacology

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

(2019) Alberto Pauletti et al.   BRAIN

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

(2019) Annamaria Vezzani et al.   Nature Reviews Neurology

Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures

(2019) Garima Tanwar et al.   Scientific Reports

Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury

(2019) Evan M. Lutton et al.   Frontiers in Neurology

Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish

(2019) Meng Jin et al.   NEUROPHARMACOLOGY

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

(2019) Diogo Vilar da Fonsêca et al.   Biomolecules

Apoptosis caused by triterpenes and phytosterols and antioxidant activity of an enriched flavonoid extract and from Passiflora mucronata

(2018) Isabel Cristina Vieira da Silva et al.   Anti-Cancer Agents in Medicinal Chemistry

Anti-melanogenic activity of schaftoside in Rhizoma Arisaematis by increasing autophagy in B16F1 cells

(2018) Pan Soo Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish

(2018) Meng Jin et al.   NEUROCHEMICAL RESEARCH

Alterations of apoptosis and autophagy in developing brain of rats with epilepsy: Changes in LC3, P62, Beclin-1 and Bcl-2 levels

(2018) Qinrui Li et al.   NEUROSCIENCE RESEARCH

Oxidative stress in epilepsy

(2018) Ursula Geronzi et al.   Expert Review of Neurotherapeutics

Orthosiphon stamineus Leaf Extract Affects TNF-α and Seizures in a Zebrafish Model

(2018) Brandon Kar Meng Choo et al.   Frontiers in Pharmacology

A Systematic Review on Non-mammalian Models in Epilepsy Research

(2018) Muhammad Faiz Johan Arief et al.   Frontiers in Pharmacology

Role of inflammation in epilepsy and neurobehavioral comorbidities: Implication for therapy

(2018) Yam Nath Paudel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GABAA receptor signalling mechanisms revealed by structural pharmacology

(2018) Simonas Masiulis et al.   NATURE

The GSK3β inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease

(2018) Daniel Koehler et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy

(2017) Melissa L. Barker-Haliski et al.   EPILEPSIA

Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model

(2017) Meijing Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Novel Model of Traumatic Brain Injury in Adult Zebrafish Demonstrates Response to Injury and Treatment Comparable with Mammalian Models

(2017) Victoria McCutcheon et al.   JOURNAL OF NEUROTRAUMA

Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

(2017) Mona Hashemian et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish

(2017) Antonella Pisera-Fuster et al.   SYNAPSE

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

(2016) Jo Sourbron et al.   ACS Chemical Neuroscience

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

(2016) Valerio Chiurchiù et al.   Oxidative Medicine and Cellular Longevity

Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo

(2016) Feiya Sheng et al.   Frontiers in Pharmacology

Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress

(2015) Jagatheesan Nataraj et al.   NUTRITIONAL NEUROSCIENCE

Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models

(2013) Olivia Erin Buenafe et al.   ACS Chemical Neuroscience

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

(2013) Tatiana Afrikanova et al.   PLoS One

Hooked on benzodiazepines: GABAA receptor subtypes and addiction

(2011) Kelly R. Tan et al.   TRENDS IN NEUROSCIENCES

β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease

(2010) Li Wan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Posttraumatic epilepsy: The challenge of translating discoveries in the laboratory to pathways to a cure

(2009) Marc A. Dichter   EPILEPSIA

Botanicals and herbs: A traditional approach to treating epilepsy

(2009) Steven C. Schachter   Neurotherapeutics

Patterns of hippocampal neuronal loss and axon reorganization of the dentate gyrus in the mouse pilocarpine model of temporal lobe epilepsy

(2008) Si Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of Brain Inflammation in Epileptogenesis

(2008) Jieun Choi et al.   YONSEI MEDICAL JOURNAL