Gastrodin Suppresses Pentylenetetrazole-Induced Seizures Progression by Modulating Oxidative Stress in Zebrafish

Gastrodin ameliorates spinal cord injury via antioxidant and anti-inflammatory effects

(2016) Fangtao Du et al.   ACTA BIOCHIMICA POLONICA

Exposure to mercuric chloride induces developmental damage, oxidative stress and immunotoxicity in zebrafish embryos-larvae

(2016) Qun-Fang Zhang et al.   AQUATIC TOXICOLOGY

The Role of Gastrodin on Hippocampal Neurons after N-Methyl-D-Aspartate Excitotoxicity and Experimental Temporal Lobe Seizures

(2016) Shi-Bing Wong   CHINESE JOURNAL OF PHYSIOLOGY

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

Gastrodin Reduces the Severity of Status Epilepticus in the Rat Pilocarpine Model of Temporal Lobe Epilepsy by Inhibiting Nav1.6 Sodium Currents

(2016) Hui Shao et al.   NEUROCHEMICAL RESEARCH

Antioxidative–oxidative balance in epilepsy patients on antiepileptic therapy: a prospective case–control study

(2016) Selda Keskin Guler et al.   NEUROLOGICAL SCIENCES

Perfusion of gastrodin in abdominal aorta for alleviating spinal cord ischemia reperfusion injury

(2016) Hua Fang et al.   Asian Pacific Journal of Tropical Medicine

Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice

(2016) Liming Chen et al.   Neuroscience Bulletin

Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish)

(2015) Bianca A. Torres-Hernández et al.   BMC Complementary and Alternative Medicine

Social cognition dysfunctions in patients with epilepsy: Evidence from patients with temporal lobe and idiopathic generalized epilepsies

(2015) Sabrina Realmuto et al.   EPILEPSY & BEHAVIOR

Anticonvulsive and neuroprotective effects of synergetic combination of phenytoin and gastrodin on the convulsion induced by penicillin in mice

(2015) Ziqi Zhou et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Epilepsy: new advances

(2015) Solomon L Moshé et al.   LANCET

Animal models in epilepsy research: legacies and new directions

(2015) Brian P Grone et al.   NATURE NEUROSCIENCE

Gastrodin Alleviates Cerebral Ischemic Damage in Mice by Improving Anti-oxidant and Anti-inflammation Activities and Inhibiting Apoptosis Pathway

(2015) Zhengwu Peng et al.   NEUROCHEMICAL RESEARCH

Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish

(2015) Anna Maria Siebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway

(2015) Li-Li Qu et al.   PHYTOTHERAPY RESEARCH

On the nature of seizure dynamics

(2014) Viktor K. Jirsa et al.   BRAIN

Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neurons

(2014) Fang Qiu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2–Nrf2 signaling pathway

(2014) Xiao-Li Wang et al.   LIFE SCIENCES

Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells

(2014) Genling Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Gastrodin alleviates memory deficits and reduces neuropathology in a mouse model of Alzheimer's disease

(2014) Yikui Hu et al.   NEUROPATHOLOGY

Seizure activity results in calcium- and mitochondria-independent ROS production via NADPH and xanthine oxidase activation

(2014) S Kovac et al.   Cell Death & Disease

Gastrodin Suppresses the Amyloidβ-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats

(2014) Peng-zhi Chen et al.   NEURAL PLASTICITY

Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish

(2013) Xuesong Zhao et al.   AQUATIC TOXICOLOGY

Gastrodin attenuation of the inflammatory response in H9c2 cardiomyocytes involves inhibition of NF-κB and MAPKs activation via the phosphatidylinositol 3-kinase signaling

(2013) Ping Yang et al.   BIOCHEMICAL PHARMACOLOGY

Post-treatment of an NADPH oxidase inhibitor prevents seizure-induced neuronal death

(2013) Jin Hee Kim et al.   BRAIN RESEARCH

Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

(2013) Hemant Kumar et al.   Evidence-based Complementary and Alternative Medicine

Gastrodin ameliorates Parkinson’s disease by downregulating connexin 43

(2013) YU WANG et al.   Molecular Medicine Reports

Antioxidant, Anticonvulsive and Neuroprotective Effects of Dapsone and Phenobarbital Against Kainic Acid-Induced Damage in Rats

(2013) Araceli Diaz-Ruiz et al.   NEUROCHEMICAL RESEARCH

Validation of the Zebrafish Pentylenetetrazol Seizure Model: Locomotor versus Electrographic Responses to Antiepileptic Drugs

(2013) Tatiana Afrikanova et al.   PLoS One

A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors

(2012) Robert F. Hunt et al.   EXPERIMENTAL NEUROLOGY

Double-Masked, Placebo-Controlled Study of Intravenous Levetiracetam for the Treatment of Status Epilepticus and Acute Repetitive Seizures in Dogs

(2012) B.T. Hardy et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Novel Animal Models of Pediatric Epilepsy

(2012) Stéphane Auvin et al.   Neurotherapeutics

Gastrodin Inhibits Allodynia and Hyperalgesia in Painful Diabetic Neuropathy Rats by Decreasing Excitability of Nociceptive Primary Sensory Neurons

(2012) Wei Sun et al.   PLoS One

Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish

(2012) Lu Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The relevance of individual genetic background and its role in animal models of epilepsy

(2011) P. Elyse Schauwecker   EPILEPSY RESEARCH

Gastrodin Inhibits Expression of Inducible NO Synthase, Cyclooxygenase-2 and Proinflammatory Cytokines in Cultured LPS-Stimulated Microglia via MAPK Pathways

(2011) Ji-Nan Dai et al.   PLoS One

Environmentally induced oxidative stress in aquatic animals

(2010) Volodymyr I. Lushchak   AQUATIC TOXICOLOGY

Oxidative Stress in The Hippocampus During Experimental Seizures Can Be Ameliorated With The Antioxidant Ascorbic Acid

(2010) Ítala Mônica Sales Santos et al.   Oxidative Medicine and Cellular Longevity

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Seizure susceptibility and the brain regional sensitivity to oxidative stress in male and female rats in the lithium-pilocarpine model of temporal lobe epilepsy

(2009) Sandra Peternel et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: Role of NMDA receptor activation and NMDA dependent calcium entry

(2008) Laxmikant S. Deshpande et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stress

(2008) Jorge Limón-Pacheco et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH