Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases

Norcyanine-Carbamates Are Versatile Near-Infrared Fluorogenic Probes

(2021) Syed Muhammad Usama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-infrared fluorescent probe with large stokes shift for detecting Human Neutrophil elastase in living cells

(2021) Wenda Zhang et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes

(2020) Simon J. Mountford et al.   ACS Chemical Biology

A Near-Infrared Peptide Probe with Tumor-Specific Excretion-Retarded Effect for Image-Guided Surgery of Renal Cell Carcinoma

(2020) Hong-Wei An et al.   ACS Nano

Activatable Polymeric Reporter For Near-infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer

(2020) Kanyi Pu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

(2020) Tomasz Janiszewski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying

(2020) Haidong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Near-Infrared Fluorescent Macromolecular Reporters for Real-Time Imaging and Urinalysis of Cancer Immunotherapy

(2020) Shasha He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances of PET imaging in clinical radiation oncology

(2020) M. Unterrainer et al.   Radiation Oncology

Activity-based ratiometric fluorescent small-molecule probe for endogenously monitoring neutrophil elastase in living cells

(2020) Ting Cao et al.   ANALYTICA CHIMICA ACTA

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

(2020) Nicole D. Barth et al.   Nature Communications

Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

(2020) Frans V. Suurs et al.   EJNMMI Research

Granzyme B nanoreporter for early monitoring of tumor response to immunotherapy

(2020) Anh Nguyen et al.   Science Advances

Activity-Based Probe for Ratiometric Fluorescence Imaging of Caspase-3 in Living Cells

(2020) Yulong Jin et al.   ANALYTICAL CHEMISTRY

A Functional Chemiluminescent Probe for in vivo Imaging of Natural Killer Cell Activity against Tumours

(2020) Jamie Scott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase

(2019) Shi-Yu Liu et al.   ANALYTICAL CHEMISTRY

Quantitatively Visualizing Tumor-Related Protease Activity in Vivo Using a Ratiometric Photoacoustic Probe

(2019) Ling Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In search of definitions: Cancer-associated fibroblasts and their markers

(2019) Martin Nurmik et al.   INTERNATIONAL JOURNAL OF CANCER

SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism

(2019) Sam Benson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Non-invasive early detection of acute transplant rejection via nanosensors of granzyme B activity

(2019) Quoc D. Mac et al.   Nature Biomedical Engineering

Rational Design and Synthesis of a Metalloproteinase-Activatable Probe for Dual-Modality Imaging of Metastatic Lymph Nodes in Vivo

(2019) Ling Yin et al.   JOURNAL OF ORGANIC CHEMISTRY

Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury

(2019) Jiaguo Huang et al.   NATURE MATERIALS

Biomedical Imaging: Principles, Technologies, Clinical Aspects, Contrast Agents, Limitations and Future Trends in Nanomedicines

(2019) Justine Wallyn et al.   PHARMACEUTICAL RESEARCH

In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF 4 –CaCO 3 Nanoconjugates

(2019) Zhigao Yi et al.   ADVANCED MATERIALS

Unimolecular Chemo-fluoro-luminescent Reporter for Crosstalk-Free Duplex Imaging of Hepatotoxicity

(2019) Penghui Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages

(2019) Antonio Fernandez et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting MMP-14 for dual PET and fluorescence imaging of glioma in preclinical models

(2019) Benjamin B. Kasten et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Non-invasive in vivo imaging of caspase-1 activation enables rapid and spatiotemporal detection of acute and chronic inflammatory disorders

(2019) Young Ji Ko et al.   BIOMATERIALS

Advances in clinical MRI technology

(2019) Mukesh G. Harisinghani et al.   Science Translational Medicine

In vivo tumor imaging by a γ-glutamyl transpeptidase-activatable near-infrared fluorescent probe

(2018) Lihong Li et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Near-Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid

(2018) Qingqing Miao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Silicon Rhodamine-Based Near-Infrared Fluorescent Probe for γ-Glutamyltransferase

(2018) Ryu J. Iwatate et al.   BIOCONJUGATE CHEMISTRY

Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging

(2018) Brian C. Wilson et al.   JOURNAL OF BIOMEDICAL OPTICS

Design of Aminopeptidase N Inhibitors as Anti-cancer Agents

(2018) Sk. Abdul Amin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

(2018) Marcin Poreba et al.   Chemical Science

A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

(2018) Jie Xing et al.   Journal of Materials Chemistry B

Tricarbocyanine N-triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo

(2018) Richard J. Mellanby et al.   Chemical Science

Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation

(2018) Hak Soo Choi et al.   Molecular Imaging

Fluorescence-Guided Cancer Diagnosis and Surgery by a Zero Cross-Talk Ratiometric Near-Infrared γ-Glutamyltranspeptidase Fluorescent Probe

(2018) Juan Ou-Yang et al.   ANALYTICAL CHEMISTRY

Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils

(2017) Paulina Kasperkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo imaging of leucine aminopeptidase activity in drug-induced liver injury and liver cancer via a near-infrared fluorescent probe

(2017) Xinyuan He et al.   Chemical Science

The “Phagocytic Synapse” and Clearance of Apoptotic Cells

(2017) Nicole D. Barth et al.   Frontiers in Immunology

Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates

(2017) Antonio Fernandez et al.   ACS Central Science

In Situ Ratiometric Quantitative Tracing of Intracellular Leucine Aminopeptidase Activity via an Activatable Near-Infrared Fluorescent Probe

(2016) Kaizhi Gu et al.   ACS Applied Materials & Interfaces

Monitoring γ -glutamyl transpeptidase activity and evaluating its inhibitors by a water-soluble near-infrared fluorescent probe

(2016) Lihong Li et al.   BIOSENSORS & BIOELECTRONICS

Optoacoustic Imaging of Human Vasculature: Feasibility by Using a Handheld Probe

(2016) Adrian Taruttis et al.   RADIOLOGY

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

(2016) Melodi Javid Whitley et al.   Science Translational Medicine

Leucine aminopeptidase may contribute to the intrinsic resistance of cancer cells toward cisplatin as revealed by an ultrasensitive fluorescent probe

(2016) Qiuyu Gong et al.   Chemical Science

Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets

(2016) Sonia Verma et al.   Frontiers in Pharmacology

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

(2015) Leslie O. Ofori et al.   ACS Chemical Biology

Detection of Intestinal Cancer by Local, Topical Application of a Quenched Fluorescence Probe for Cysteine Cathepsins

(2015) Ehud Segal et al.   CHEMISTRY & BIOLOGY

Imaging Granzyme B Activity Assesses Immune-Mediated MyocarditisNovelty and Significance

(2015) Masanori Konishi et al.   CIRCULATION RESEARCH

Design of a Highly Selective Quenched Activity-Based Probe and Its Application in Dual Color Imaging Studies of Cathepsin S Activity Localization

(2015) Kristina Oresic Bender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Moving targets: Emerging roles for MMPs in cancer progression and metastasis

(2015) Gemma Shay et al.   MATRIX BIOLOGY

Specific Light-Up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for the Targeted and Image-Guided Photodynamic Ablation of Cancer Cells

(2014) Youyong Yuan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action

(2014) Einat Kisin-Finfer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Advances in fluorescence labeling strategies for dynamic cellular imaging

(2014) Kevin M Dean et al.   Nature Chemical Biology

Bioorthogonal cyclization-mediated in situ self-assembly of small-molecule probes for imaging caspase activity in vivo

(2014) Deju Ye et al.   Nature Chemistry

Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses

(2014) Sung-Jin Park et al.   Stem Cell Research

Rational Design of Matrix Metalloproteinase-13 Activatable Probes for Enhanced Specificity

(2013) Lei Zhu et al.   ACS Chemical Biology

Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

(2013) Martijn Verdoes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes

(2013) Jun Cheng Er et al.   Chemical Science

Advances in Fluorescence and Bioluminescence Imaging

(2012) Takeaki Ozawa et al.   ANALYTICAL CHEMISTRY

Spatially Resolved Monitoring of Neutrophil Elastase Activity with Ratiometric Fluorescent Reporters

(2012) Stefanie Gehrig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activatable Near-Infrared Fluorescent Probe for In Vivo Imaging of Fibroblast Activation Protein-alpha

(2012) Jinbo Li et al.   BIOCONJUGATE CHEMISTRY

Real-time In Vivo Molecular Detection of Primary Tumors and Metastases with Ratiometric Activatable Cell-Penetrating Peptides

(2012) E. N. Savariar et al.   CANCER RESEARCH

A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages

(2012) Martijn Verdoes et al.   CHEMISTRY & BIOLOGY

An Optimized Activity-Based Probe for the Study of Caspase-6 Activation

(2012) Laura E. Edgington et al.   CHEMISTRY & BIOLOGY

Design Strategy for a Near-Infrared Fluorescence Probe for Matrix Metalloproteinase Utilizing Highly Cell Permeable Boron Dipyrromethene

(2012) Takuya Myochin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Real-Time Video Imaging of Protease Expression In Vivo

(2012) Lei Zhu et al.   Theranostics

Translation of Near-Infrared Fluorescence Imaging Technologies: Emerging Clinical Applications

(2011) E.M. Sevick-Muraca   Annual Review of Medicine

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Caspases and cancer

(2011) M Olsson et al.   CELL DEATH AND DIFFERENTIATION

A Photostable Near-Infrared Protein Labeling Dye for In Vivo Imaging

(2011) Animesh Samanta et al.   Chemistry-An Asian Journal

Synthesis and characterization of a cell-permeable near-infrared fluorescent deoxyglucose analogue for cancer cell imaging

(2011) Marc Vendrell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rapid Cancer Detection by Topically Spraying a  -Glutamyltranspeptidase-Activated Fluorescent Probe

(2011) Y. Urano et al.   Science Translational Medicine

Serine proteases

(2009) Enrico Di Cera   IUBMB LIFE

The Prolyl-Aminodipeptidases and their Inhibitors as Therapeutic Targets for Fibrogenic Disorders

(2009) Lucienne Juillerat-Jeanneret et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

(2009) Abigail S. Haka et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation

(2009) Amanda Cobos-Correa et al.   Nature Chemical Biology

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model

(2009) E. M. Barnett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Imaging matrix metalloproteinases in cancer

(2008) Randy L. Scherer et al.   CANCER AND METASTASIS REVIEWS

The moonlighting enzyme CD13: old and new functions to target

(2008) Paola Mina-Osorio   TRENDS IN MOLECULAR MEDICINE