Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

Roadmap for the development and GMP translation of optical tracers cetuximab-800CW and trastuzumab-800CW

(2019) Matthijs D Linssen et al.   JOURNAL OF NUCLEAR MEDICINE

Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

(2019) Lisa König et al.   BMC CANCER

Real-time, intraoperative detection of residual breast cancer in lumpectomy cavity walls using a novel cathepsin-activated fluorescent imaging system

(2018) Barbara L. Smith et al.   BREAST CANCER RESEARCH AND TREATMENT

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

(2018) Marcin Poreba et al.   Chemical Science

First-in-human study of PET and optical dual-modality image-guided surgery in glioblastoma using 68Ga-IRDye800CW-BBN

(2018) Deling Li et al.   Theranostics

68Ga-BBN-RGD PET/CT for GRPR and Integrin αvβ3 Imaging in Patients with Breast Cancer

(2018) Jingjing Zhang et al.   Theranostics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Implementation and benchmarking of a novel analytical framework to clinically evaluate tumor-specific fluorescent tracers

(2018) Marjory Koller et al.   Nature Communications

Near-infrared fluorescence molecular endoscopy detects dysplastic oesophageal lesions using topical and systemic tracer of vascular endothelial growth factor A

(2017) Wouter B Nagengast et al.   GUT

Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters: A Study of 1,432 Primary Tumors

(2017) Clément Morgat et al.   JOURNAL OF NUCLEAR MEDICINE

Optimization of a Protease Activated Probe for Optical Surgical Navigation

(2017) Joshua J. Yim et al.   MOLECULAR PHARMACEUTICS

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin

(2017) Lovro Kramer et al.   Theranostics

Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study

(2016) Laetitia E. Lamberts et al.   CLINICAL CANCER RESEARCH

Development, preclinical safety, formulation, and stability of clinical grade bevacizumab-800CW, a new near infrared fluorescent imaging agent for first in human use

(2016) Eva J. ter Weele et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer

(2016) Melodi Javid Whitley et al.   Science Translational Medicine

Association of Breast Conservation Surgery for Cancer With 90-Day Reoperation Rates in New York State

(2016) Abby J. Isaacs et al.   JAMA Surgery

Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery

(2015) Leslie O. Ofori et al.   ACS Chemical Biology

Fluorescence-guided resection of experimental malignant glioma using cetuximab-IRDye 800CW

(2015) Jason M. Warram et al.   BRITISH JOURNAL OF NEUROSURGERY

Detection of Intestinal Cancer by Local, Topical Application of a Quenched Fluorescence Probe for Cysteine Cathepsins

(2015) Ehud Segal et al.   CHEMISTRY & BIOLOGY

Safety and Tumor Specificity of Cetuximab-IRDye800 for Surgical Navigation in Head and Neck Cancer

(2015) E. L. Rosenthal et al.   CLINICAL CANCER RESEARCH

Detection of colorectal polyps in humans using an intravenously administered fluorescent peptide targeted against c-Met

(2015) Jacobus Burggraaf et al.   NATURE MEDICINE

Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes

(2015) Nimali P Withana et al.   Nature Protocols

In Vivo Imaging of Mouse Tumors by a Lipidated Cathepsin S Substrate

(2014) Hai-Yu Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer

(2014) Meena S. Moran et al.   JOURNAL OF CLINICAL ONCOLOGY

Intraoperative assessment of margins in breast conservative surgery-still in use?

(2014) Marc Thill et al.   JOURNAL OF SURGICAL ONCOLOGY

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

(2014) Lisa Sevenich et al.   NATURE CELL BIOLOGY

Repeat Surgery After Breast Conservation for the Treatment of Stage 0 to II Breast Carcinoma

(2014) Lee G. Wilke et al.   JAMA Surgery

Improved Quenched Fluorescent Probe for Imaging of Cysteine Cathepsin Activity

(2013) Martijn Verdoes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages

(2012) Martijn Verdoes et al.   CHEMISTRY & BIOLOGY

Intraoperative Near-Infrared Fluorescence Tumor Imaging with Vascular Endothelial Growth Factor and Human Epidermal Growth Factor Receptor 2 Targeting Antibodies

(2011) A. G. T. Terwisscha van Scheltinga et al.   JOURNAL OF NUCLEAR MEDICINE

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results

(2011) Gooitzen M van Dam et al.   NATURE MEDICINE

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Macrophages define the invasive microenvironment in breast cancer

(2008) Jeffrey W. Pollard   JOURNAL OF LEUKOCYTE BIOLOGY

Selective Activity-Based Probes for Cysteine Cathepsins

(2007) Anja Watzke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION