Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Electron Transfer/Higher Energy Collisional Dissociation of Doubly Charged Peptide Ions: Identification of Labile Protein Phosphorylations

(2019) Martin Penkert et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

The case for a universal hepatitis C vaccine to achieve hepatitis C elimination

(2019) Nick Scott et al.   BMC Medicine

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation

(2019) Gemma Hardman et al.   EMBO JOURNAL

The complex challenges of HIV vaccine development require renewed and expanded global commitment

(2019) Linda-Gail Bekker et al.   LANCET

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

(2018) Anju Sreelatha et al.   CELL

Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update

(2018) Clement M. Potel et al.   ANALYTICAL CHEMISTRY

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

(2017) Clara C. Posthuma et al.   VIRUS RESEARCH

Structural Analysis of Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 7α (NSP7α) and Identification of Its Interaction with NSP9

(2017) Jiaping Chen et al.   Frontiers in Microbiology

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation

(2016) Canhua Lu et al.   Science Signaling

Identification of Fic-1 as an enzyme that inhibits bacterial DNA replication by AMPylating GyrB, promoting filament formation

(2016) Canhua Lu et al.   Science Signaling

The SEQUEST Family Tree

(2015) David L. Tabb   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

(2015) Kathleen C. Lehmann et al.   NUCLEIC ACIDS RESEARCH

Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology

(2015) Alexander Harms et al.   Cell Reports

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

(2015) Steffen Preissler et al.   eLife

Unfolded Protein Response-regulatedDrosophilaFic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis

(2014) Hyeilin Ham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation in the Bacterial Stress Response

(2013) Andreas Schmidt et al.   MOLECULAR & CELLULAR PROTEOMICS

Mutagenesis analysis of porcine reproductive and respiratory syndrome virus nonstructural protein 7

(2013) Minze Zhang et al.   VIRUS GENES

HIV-1 Antiretroviral Drug Therapy

(2013) E. J. Arts et al.   Cold Spring Harbor Perspectives in Medicine

Studying the fragmentation behavior of peptides with arginine phosphorylation and its influence on phospho-site localization

(2012) Andreas Schmidt et al.   PROTEOMICS

Characterization of AMPylation on Threonine, Serine, and Tyrosine Using Mass Spectrometry

(2011) Yan Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7 

(2011) I. Manolaridis et al.   JOURNAL OF VIROLOGY

Adenylylation: renaissance of a forgotten post-translational modification

(2011) Aymelt Itzen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phosphopeptide fragmentation and analysis by mass spectrometry

(2009) Paul J. Boersema et al.   JOURNAL OF MASS SPECTROMETRY

The Fic Domain: Regulation of Cell Signaling by Adenylylation

(2009) Carolyn A. Worby et al.   MOLECULAR CELL

Evaluation of Gas-Phase Rearrangement and Competing Fragmentation Reactions on Protein Phosphorylation Site Assignment Using Collision Induced Dissociation-MS/MS and MS3

(2008) Amanda M. Palumbo et al.   ANALYTICAL CHEMISTRY

AMPylation of Rho GTPases by Vibrio VopS Disrupts Effector Binding and Downstream Signaling

(2008) M. L. Yarbrough et al.   SCIENCE