Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion

Modulation of Microglia Polarization through Silencing of NF-κB p65 by Functionalized Curdlan Nanoparticle-Mediated RNAi

(2020) Tsogzolmaa Ganbold et al.   ACS Applied Materials & Interfaces

Targeting microglia L‐type voltage‐dependent calcium channels for the treatment of central nervous system disorders

(2020) Sarah C. Hopp   JOURNAL OF NEUROSCIENCE RESEARCH

Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation

(2020) Sandip Mukherjee et al.   NATURE IMMUNOLOGY

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

(2020) Yue Qin et al.   BRAIN BEHAVIOR AND IMMUNITY

Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia

(2020) Dai-Chao Ma et al.   EXPERIMENTAL NEUROLOGY

Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway

(2020) Xiaoxue Du et al.   NEURAL PLASTICITY

Disease Stage-Associated Alterations in Learning and Memory through the Electroacupuncture Modulation of the Cortical Microglial M1/M2 Polarization in Mice with Alzheimer’s Disease

(2020) Long Li et al.   NEURAL PLASTICITY

Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer’s Disease Animal Model

(2020) Yujie Li et al.   NEURAL PLASTICITY

Zinc inhibited LPS-induced inflammatory responses by upregulating A20 expression in microglia BV2 cells

(2019) Li Hongxia et al.   JOURNAL OF AFFECTIVE DISORDERS

The role of microglia in viral encephalitis: a review

(2019) Zhuangzhuang Chen et al.   Journal of Neuroinflammation

Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia

(2019) Ji Ahn et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neuroinflammation: friend and foe for ischemic stroke

(2019) Richard L. Jayaraj et al.   Journal of Neuroinflammation

Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1

(2019) Franziska M. Collmann et al.   Frontiers in Immunology

USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation

(2019) Jingyan Xiang et al.   NEUROSCIENCE

Fractalkine Modulates Microglia Metabolism in Brain Ischemia

(2019) Clotilde Lauro et al.   Frontiers in Cellular Neuroscience

PLK 4 deubiquitination by Spata2‐CYLD suppresses NEK7‐mediated NLRP3 inflammasome activation at the centrosome

(2019) Xiao‐Dong Yang et al.   EMBO JOURNAL

Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

(2019) Shi-Yang Ye et al.   Journal of Neuroinflammation

Minocycline treatment prevents depression and anxiety-like behaviors and promotes neuroprotection after experimental ischemic stroke

(2019) Quezya Mendes Camargos et al.   BRAIN RESEARCH BULLETIN

Cylindromatosis mediates neuronal cell death in vitro and in vivo

(2018) Goutham K. Ganjam et al.   CELL DEATH AND DIFFERENTIATION

Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1

(2018) Jinkun Wang et al.   Scientific Reports

Fractalkine/CX3CR1 is involved in the cross-talk between neuron and glia in neurological diseases

(2018) Piao Luo et al.   BRAIN RESEARCH BULLETIN

Electroacupuncture brain protection during ischemic stroke: A role for the parasympathetic nervous system

(2017) Laiting Chi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deletion of the Fractalkine Receptor, CX3CR1, Improves Endogenous Repair, Axon Sprouting, and Synaptogenesis after Spinal Cord Injury in Mice

(2017) Camila M. Freria et al.   JOURNAL OF NEUROSCIENCE

Downregulation of USP4 Promotes Activation of Microglia and Subsequent Neuronal Inflammation in Rat Spinal Cord After Injury

(2017) Xingjie Jiang et al.   NEUROCHEMICAL RESEARCH

Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats

(2017) Jin Jiang et al.   Frontiers in Molecular Neuroscience

Role of CX3CL1 in Diseases

(2016) WangMi Liu et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: Possible role of NLRP3 inflammasome pathway

(2016) Joanna Ślusarczyk et al.   BIOCHEMICAL PHARMACOLOGY

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats

(2016) Jian Zhan et al.   Journal of Neuroinflammation

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

(2016) Carolina Cunha et al.   MEDIATORS OF INFLAMMATION

Cylindromatosis-A Protective Molecule against Liver Diseases

(2016) Claus Hellerbrand et al.   MEDICINAL RESEARCH REVIEWS

Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation

(2016) JUN REN et al.   Molecular Medicine Reports

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

(2016) Xiangrong Liu et al.   STROKE

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects

(2015) Ophélia Le Thuc et al.   Annals of the New York Academy of Sciences

DUBs, the regulation of cell identity and disease: Figure 6

(2015) J. Heideker et al.   BIOCHEMICAL JOURNAL

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

CX3CL1/CX3CR1-Mediated Microglia Activation Plays a Detrimental Role in Ischemic Mice Brain via p38MAPK/PKC Pathway

(2015) Yong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Electroacupuncture Could Regulate the NF-κB Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats

(2013) Wen-yi Qin et al.   Evidence-based Complementary and Alternative Medicine

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

(2013) Stefano Fumagalli et al.   GLIA

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

(2013) Helena W Morrison et al.   Journal of Neuroinflammation

Microglia during development and aging

(2013) G. Jean Harry   PHARMACOLOGY & THERAPEUTICS

Neuron-glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage

(2013) G. K. Sheridan et al.   Open Biology

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

(2012) Kostas Nikolaou et al.   CANCER CELL

CYLD: a deubiquitination enzyme with multiple roles in cancer

(2011) Ramin Massoumi   Future Oncology

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Tumor suppressor CYLD: negative regulation of NF-κB signaling and more

(2008) G. Courtois   CELLULAR AND MOLECULAR LIFE SCIENCES