Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson’s Disease Mouse Model

Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson’s disease model

(2021) Dongdong Zhang et al.   Journal of Neuroinflammation

Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy

(2020) Liyan Hou et al.   ANTIOXIDANTS & REDOX SIGNALING

Integrin CD11b mediates locus coeruleus noradrenergic neurodegeneration in a mouse Parkinson’s disease model

(2020) Liyan Hou et al.   Journal of Neuroinflammation

Glibenclamide attenuates 2,5-hexanedione-induced neurotoxicity in the spinal cord of rats through mitigation of NLRP3 inflammasome activation, neuroinflammation and oxidative stress

(2020) Liyan Hou et al.   TOXICOLOGY LETTERS

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

(2019) Aijuan Yan et al.   Frontiers in Cellular Neuroscience

Minocycline Protects against Rotenone-Induced Neurotoxicity Correlating with Upregulation of Nurr1 in a Parkinson’s Disease Rat Model

(2019) Congcong Sun et al.   Biomed Research International

Contribution of microglial reaction to increased nociceptive responses in high-fat-diet (HFD)-induced obesity in male mice

(2019) Ya-Jing Liang et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis

(2019) Liyan Hou et al.   TOXICOLOGY

Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model

(2019) Liyan Hou et al.   Redox Biology

Noradrenergic dysfunction accelerates LPS-elicited inflammation-related ascending sequential neurodegeneration and deficits in non-motor/motor functions

(2019) Sheng Song et al.   BRAIN BEHAVIOR AND IMMUNITY

Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone model of Parkinson's disease

(2019) Victor Tapias et al.   Redox Biology

Ferroptosis Induction in Pentylenetetrazole Kindling and Pilocarpine-Induced Epileptic Seizures in Mice

(2019) Xiao-Yuan Mao et al.   Frontiers in Neuroscience

Lesion of the Locus Coeruleus Damages Learning and Memory Performance in Paraquat and Maneb-induced Mouse Parkinson’s Disease Model

(2019) Liyan Hou et al.   NEUROSCIENCE

Microglial activation contributes to depressive-like behavior in dopamine D3 receptor knockout mice

(2019) Jing Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Taurine protects noradrenergic locus coeruleus neurons in a mouse Parkinson’s disease model by inhibiting microglial M1 polarization

(2018) Liyan Hou et al.   AMINO ACIDS

Depletion of microglia augments the dopaminergic neurotoxicity of MPTP

(2018) Xiaoxia Yang et al.   FASEB JOURNAL

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease

(2018) Justyna Sosna et al.   Molecular Neurodegeneration

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

(2018) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

Intranasally delivered small interfering RNA-mediated suppression of scavenger receptor Mac-1 attenuates microglial phenotype switching and working memory impairment following hypoxia

(2018) Sudeshna Das et al.   NEUROPHARMACOLOGY

Minocycline diminishes the rotenone induced neurotoxicity and glial activation via suppression of apoptosis, nitrite levels and oxidative stress

(2018) Dinesh Kumar Verma et al.   NEUROTOXICOLOGY

Taurine protects dopaminergic neurons in a mouse Parkinson’s disease model through inhibition of microglial M1 polarization

(2018) Yuning Che et al.   Cell Death & Disease

2,5-Hexanedione induces dopaminergic neurodegeneration through integrin αMβ2/NADPH oxidase axis-mediated microglial activation

(2018) Cong Zhang et al.   Cell Death & Disease

Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration

(2018) Sheng Song et al.   MOLECULAR NEUROBIOLOGY

Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease

(2018) Andrew Harkin et al.   Neural Regeneration Research

Caffeic acid improves locomotor activity and lessens inflammatory burden in a mouse model of rotenone-induced nigral neurodegeneration: Relevance to Parkinson’s disease therapy

(2018) Sawsan A. Zaitone et al.   Pharmacological Reports

Allyl sulfide counteracts 1-bromopropane-induced neurotoxicity by inhibiting neuroinflammation and oxidative stress

(2018) Jinning Suo et al.   TOXICOLOGICAL SCIENCES

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations

(2018) Janos Groh et al.   GLIA

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity

(2017) Eva Czirr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β1 Neuroprotection via Inhibition of Microglial Activation in a Rat Model of Parkinson’s Disease

(2017) Xiao Chen et al.   Journal of Neuroimmune Pharmacology

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease

(2017) Sudhakar R. Subramaniam et al.   Frontiers in Aging Neuroscience

Paraquat-and Rotenone-Induced Models of Parkinson's Disease

(2017) R. Nisticò et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone

(2016) Hayate Javed et al.   BMC NEUROSCIENCE

The Anti-Inflammatory Role of Minocycline in Alzheimers Disease

(2016) J. Budni et al.   Current Alzheimer Research

The novel mechanism of rotenone-induced α-synuclein phosphorylation via reduced protein phosphatase 2A activity

(2016) Yi Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neuroprotective effect of curcumin as evinced by abrogation of rotenone-induced motor deficits, oxidative and mitochondrial dysfunctions in mouse model of Parkinson's disease

(2016) Dharmendra K. Khatri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model

(2015) Hirofumi Okubo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

The many faces of Mac-1 in autoimmune disease

(2015) Florencia Rosetti et al.   IMMUNOLOGICAL REVIEWS

Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions

(2015) Vinod Kumar et al.   MOLECULAR NEUROBIOLOGY

Gender-specific brain regional variation of neurons, endogenous estrogen, neuroinflammation and glial cells during rotenone-induced mouse model of Parkinson’s disease

(2015) S. Mitra et al.   NEUROSCIENCE

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

(2015) Emdadul Haque et al.   Drug Design Development and Therapy

Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

(2014) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Microglial CR3 Activation Triggers Long-Term Synaptic Depression in the Hippocampus via NADPH Oxidase

(2014) Jingfei Zhang et al.   NEURON

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells

(2013) Rituraj Pal et al.   FEBS LETTERS

Pesticides, Microglial NOX2, and Parkinson's Disease

(2013) Thomas Taetzsch et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Rotenone Directly Induces BV2 Cell Activation via the p38 MAPK Pathway

(2013) Feng Gao et al.   PLoS One

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease

(2011) D. Maiguel et al.   Science Signaling

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission

(2010) Ann Van der Jeugd et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Quantifying Western blots: Pitfalls of densitometry

(2009) Max Gassmann et al.   ELECTROPHORESIS

Effects of chronic low dose rotenone treatment on human microglial cells

(2009) Shamim B Shaikh et al.   Molecular Neurodegeneration