2,5-Hexanedione induces dopaminergic neurodegeneration through integrin αMβ2/NADPH oxidase axis-mediated microglial activation

Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation

(2017) Liyan Hou et al.   TOXICOLOGY

Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase

(2017) Yinxi Wang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade

(2015) S. Magwenzi et al.   BLOOD

Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson’s disease models

(2015) Qingshan Wang et al.   BRAIN

Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice

(2015) Qingshan Wang et al.   CLINICAL SCIENCE

A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis

(2015) Lulu Jiang et al.   GLIA

The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets

(2015) Yibing Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microglial regulation of immunological and neuroprotective functions of astroglia

(2014) Shih-Heng Chen et al.   GLIA

Potent Anti-Inflammatory and Neuroprotective Effects of TGF- 1 Are Mediated through the Inhibition of ERK and p47phox-Ser345 Phosphorylation and Translocation in Microglia

(2014) L. Qian et al.   JOURNAL OF IMMUNOLOGY

Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase

(2014) Q. Wang et al.   JOURNAL OF NEUROSCIENCE

Environmental Toxins and Parkinson's Disease

(2013) Samuel M. Goldman   Annual Review of Pharmacology and Toxicology

NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration

(2013) Liya Qin et al.   GLIA

The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function

(2013) Shannon Levesque et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease and the environment: Beyond pesticides

(2012) W. Michael Caudle et al.   NEUROTOXICOLOGY

Parthenolide Inhibits the LPS-induced Secretion of IL-6 and TNF-α and NF-κB Nuclear Translocation in BV-2 Microglia

(2012) Paolo Magni et al.   PHYTOTHERAPY RESEARCH

Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence

(2012) Edward A. Lock et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation

(2011) Qingshan Wang et al.   BIOCHEMICAL PHARMACOLOGY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epidemiology and etiology of Parkinson’s disease: a review of the evidence

(2011) Karin Wirdefeldt et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration

(2011) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

A review of potential neurotoxic mechanisms among three chlorinated organic solvents

(2011) Ambuja S. Bale et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Severe dopaminergic pathways damage in a case of chronic toluene abuse

(2009) Sokratis G. Papageorgiou et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease

(2009) Lilia Marinova-Mutafchieva et al.   JOURNAL OF NEUROCHEMISTRY

Src kinase participates in LPS-induced activation of NADPH oxidase

(2009) Jennifer Check et al.   MOLECULAR IMMUNOLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Regulation of phagocyte migration and recruitment by Src-family kinases

(2008) A. Baruzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Pesticide/Environmental Exposures and Parkinson's Disease in East Texas

(2008) Amanpreet S. Dhillon et al.   Journal of Agromedicine

Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity

(2007) Don M. Gash et al.   ANNALS OF NEUROLOGY