Stress-Responsive Periplasmic Chaperones in Bacteria

Mechanism of the small ATP-independent chaperone Spy is substrate specific

(2021) Rishav Mitra et al.   Nature Communications

Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

(2020) Antonio N. Calabrese et al.   Nature Communications

A metabolite binding protein moonlights as a bile‐responsive chaperone

(2020) Changhan Lee et al.   EMBO JOURNAL

Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity

(2020) Wei He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Functions and Mechanisms of Action of Small Heat Shock Proteins

(2019) Axel Mogk et al.   Annual Review of Microbiology

Protein folding while chaperone bound is dependent on weak interactions

(2019) Kevin Wu et al.   Nature Communications

The chaperone activity of DsbG and Spy restore peptidoglycan biosynthesis arrest in the elyC mutant by preventing envelope protein aggregation.

(2018) Imène Kouidmi et al.   JOURNAL OF BACTERIOLOGY

The Mechanism of HdeA Unfolding and Chaperone Activation

(2018) Loïc Salmon et al.   JOURNAL OF MOLECULAR BIOLOGY

Electrostatic interactions are important for chaperone–client interaction in vivo

(2018) Changhan Lee et al.   MICROBIOLOGY-SGM

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

Acid-denatured small heat shock protein HdeA from Escherichia coli forms reversible fibrils with an atypical secondary structure

(2018) Shiori Miyawaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis and mechanism of the unfolding-induced activation of HdeA, a bacterial acid response chaperone

(2018) Xing-Chi Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo chloride concentrations surge to proteotoxic levels during acid stress

(2018) Frederick Stull et al.   Nature Chemical Biology

Chaperone-client interactions: Non-specificity engenders multifunctionality

(2017) Philipp Koldewey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Forces Driving Chaperone Action

(2016) Philipp Koldewey et al.   CELL

The function of the DegP (HtrA) protein: Protease versus chaperone

(2016) Zengyi Chang   IUBMB LIFE

Implementation and Data Analysis of Tn-seq, Whole-Genome Resequencing, and Single-Molecule Real-Time Sequencing for Bacterial Genetics

(2016) Peter E. Burby et al.   JOURNAL OF BACTERIOLOGY

Visualizing chaperone-assisted protein folding

(2016) Scott Horowitz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Skp is a multivalent chaperone of outer-membrane proteins

(2016) Bob Schiffrin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualizing chaperone-assisted protein folding

(2016) Scott Horowitz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Skp is a multivalent chaperone of outer-membrane proteins

(2016) Bob Schiffrin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic analysis, structural modeling, and direct coupling analysis suggest a mechanism for phosphate signaling in Escherichia coli

(2015) Stewart G Gardner et al.   BMC GENETICS

HdeB functions as an acid-protective chaperone in bacteria.

(2015) Jan-Ulrik Dahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding Optimization In Vivo Uncovers New Chaperones

(2015) Christopher W. Lennon et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein aggregation as an antibiotic design strategy

(2015) Natalia G. Bednarska et al.   MOLECULAR MICROBIOLOGY

Substrate protein folds while it is bound to the ATP-independent chaperone Spy

(2015) Frederick Stull et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate protein folds while it is bound to the ATP-independent chaperone Spy

(2015) Frederick Stull et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HdeB chaperone activity is coupled to its intrinsic dynamic properties

(2015) Jienv Ding et al.   Scientific Reports

Mechanisms of protein-folding diseases at a glance

(2014) J. S. Valastyan et al.   Disease Models & Mechanisms

Bile salts act as effective protein-unfolding agents and instigators of disulfide stress in vivo

(2014) C. M. Cremers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Occupancy at the Onset of Oligomeric Transitions of DegP

(2014) Natalie J. Thompson et al.   STRUCTURE

A Genome-Wide Screen for Bacterial Envelope Biogenesis Mutants Identifies a Novel Factor Involved in Cell Wall Precursor Metabolism

(2014) Catherine Paradis-Bleau et al.   PLoS Genetics

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The Lipid Bilayer-Inserted Membrane Protein BamA of Escherichia coli Facilitates Insertion and Folding of Outer Membrane Protein A from Its Complex with Skp

(2013) Geetika J. Patel et al.   BIOCHEMISTRY

Comparison of the large-scale periplasmic proteomes of the Escherichia coli K-12 and B strains

(2013) Mee-Jung Han et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

The BaeSR regulon is involved in defense against zinc toxicity in E. coli

(2013) Da Wang et al.   Metallomics

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperone activation by unfolding

(2013) L. Foit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR-monitored titration of acid-stress bacterial chaperone HdeA reveals that Asp and Glu charge neutralization produces a loosened dimer structure in preparation for protein unfolding and chaperone activation

(2013) McKinzie A. Garrison et al.   PROTEIN SCIENCE

Expression dynamics of RpoS/Crl-dependent genes in Escherichia coli

(2013) Omaya Dudin et al.   RESEARCH IN MICROBIOLOGY

Bile resistance mechanisms in Lactobacillus and Bifidobacterium

(2013) Lorena Ruiz et al.   Frontiers in Microbiology

Genetic Analysis of 15 Protein Folding Factors and Proteases of the Escherichia coli Cell Envelope

(2012) J. Weski et al.   JOURNAL OF BACTERIOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Determinants of substrate specificity and biochemical properties of thesn-glycerol-3-phosphate ATP binding cassette transporter (UgpB-AEC2) ofEscherichia coli

(2012) Steven Wuttge et al.   MOLECULAR MICROBIOLOGY

Chaperone-dependent mechanisms for acid resistance in enteric bacteria

(2012) Weizhe Hong et al.   TRENDS IN MICROBIOLOGY

Adaptation and Preadaptation of Salmonella enterica to Bile

(2012) Sara B. Hernández et al.   PLoS Genetics

Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

(2011) Seokhee Kim et al.   CELL

Salt Bridges Regulate Both Dimer Formation and Monomeric Flexibility in HdeB and May Have a Role in Periplasmic Chaperone Function

(2011) Wenjian Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance

(2011) Meng Zhang et al.   Nature Chemical Biology

HTRA proteases: regulated proteolysis in protein quality control

(2011) Tim Clausen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic selection designed to stabilize proteins uncovers a chaperone called Spy

(2011) Shu Quan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phenotypic Landscape of a Bacterial Cell

(2010) Robert J. Nichols et al.   CELL

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Dissection of β-barrel outer membrane protein assembly pathways through characterizing BamA POTRA 1 mutants of Escherichia coli

(2010) Drew Bennion et al.   MOLECULAR MICROBIOLOGY

Cellular strategies for controlling protein aggregation

(2010) Jens Tyedmers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein refolding by pH-triggered chaperone binding and release

(2010) T. L. Tapley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structureEscherichia coliSpy

(2010) Eunju Kwon et al.   PROTEIN SCIENCE

Antibiotics that target protein synthesis

(2010) Lisa S. McCoy et al.   Wiley Interdisciplinary Reviews-RNA

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Escherichia coli DegP: a Structure-Driven Functional Model

(2009) J. Ortega et al.   JOURNAL OF BACTERIOLOGY

Effect of bile salts on the DNA and membrane integrity of enteric bacteria

(2009) M. E. Merritt et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Optimizing Protein Stability In Vivo

(2009) Linda Foit et al.   MOLECULAR CELL

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Global Analysis of Extracytoplasmic Stress Signaling in Escherichia coli

(2009) Stéphanie Bury-Moné et al.   PLoS Genetics

The disulfide bond formation (Dsb) system

(2008) K ITO et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genome-Wide Transcriptional Responses of Escherichia coli K-12 to Continuous Osmotic and Heat Stresses

(2008) T. S. Gunasekera et al.   JOURNAL OF BACTERIOLOGY

Solubilization of Protein Aggregates by the Acid Stress Chaperones HdeA and HdeB

(2008) Abderrahim Malki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the regulated protease and chaperone function of DegP

(2008) Tobias Krojer et al.   NATURE

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins

(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA