Article
Biochemistry & Molecular Biology
Liliya S. Chernova, Innokentii E. Vishnyakov, Janek Boerner, Mikhail I. Bogachev, Kai M. Thormann, Airat R. Kayumov
Summary: Small heat shock proteins (sHSPs) play a crucial role in stress defense in bacteria by preventing protein denaturation and aggregation. Different sHSPs have different functions and regulatory mechanisms, and can transfer substrate proteins to other chaperone systems through forming different structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Konstantin O. Muranov, Nicolay B. Poliansky, Vera A. Borzova, Sergey Y. Kleimenov
Summary: aH-Crystallin, a high molecular weight form of α-crystallin, plays a significant role in the development of cataracts. Refolding with urea increases the chaperone-like activity of α-crystallin and HMWA, while reducing their sizes. The chaperone-like activity of a-crystallin and HMWA correlates with denaturation enthalpy, suggesting a correction of misfolded proteins and rearrangement of protein structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Ting Wen, Qiao Yi Chen
Summary: This article discusses the translation regulatory mechanisms of histone H3.1 and H3.3 and their roles in tumorigenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Materials Science, Multidisciplinary
J. Bonca, S. A. Trugman
Summary: We studied the static and dynamic properties of an electron coupled to dispersive quantum optical phonons in the Holstein model on a one-dimensional lattice, finding that even small phonon dispersion significantly affects the low-energy optical response. With increasing dispersion, multiphonon excitation states become the lowest excited states of the system and determine the low-frequency response of the optical conductivity.
Article
Biochemistry & Molecular Biology
Sara Silva, Claudia Alves, Diana Duarte, Ana Costa, Bruno Sarmento, Antonio J. Almeida, Paula Gomes, Nuno Vale
Summary: Drug repurposing and drug combination are two widely used strategies to overcome the traditional development of new anticancer drugs. The study found that coupling Tacrine with CPP enhanced its antiproliferative properties, but also resulted in a considerable loss of its function as an AChE inhibitor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Optics
G. Y. Dong, H. W. Yang, S. J. Zeng, Z. Q. Shi, Y. J. Ma, C. Wen, W. B. Yang
Summary: Pulsed-laser melting of thin films has been widely studied for hyperdoping semiconductors, but the focus has mainly been on femtosecond-laser hyperdoping rather than nanosecond-laser hyperdoping. In this study, high-resistivity intrinsic Si wafers were hyperdoped with Ti through thin Ti film deposition and ns-laser melting. The resulting Si:Ti layer showed high carrier concentration, low resistivity, and increased infrared absorptance.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Pingan Zhou, Binjian Zeng, Wanzhen Yang, Jiajia Liao, Fanqi Meng, Qinghua Zhang, Lin Gu, Shuaizhi Zheng, Min Liao, Yichun Zhou
Summary: This study reveals the effects of tail-to-tail 90 degrees domain structures and charged domain walls (CDWs) on the performance of Hf0.5Zr0.5O2 (HZO) films through experimental observation and the establishment of a phase-field model. It provides a theoretical basis for the development of a new type of hafnium oxide-based ferroelectric memory system.
Article
Biochemistry & Molecular Biology
Changhoon Lee, Ho Jin Youn, Sang-Hoon Lee, Jinwoo Kim, Daeyoung Son, Joon-Yung Cha
Summary: This study investigated the positive role of plant Aha in heat stress tolerance through chaperone properties and/or activation of Hsp90 to protect substrate proteins from thermal injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Fabian Gude, Jurij Froese, Dominique Manikowski, Daniele Di Iorio, Jean-Noel Grad, Seraphine Wegner, Daniel Hoffmann, Melissa Kennedy, Ralf P. Richter, Georg Steffes, Kay Grobe
Summary: Cellular differentiation is determined by concentration gradients of morphogens. Hedgehog (Hh) morphogens spread away from their source to direct growth and pattern formation in Drosophila wing and eye discs. The study shows that Hh can interact with heparan sulfate (HS) chains to temporarily cross-link them and this interaction is crucial for Hh gradient formation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marija Iljina, Hisham Mazal, Pierre Goloubinoff, Inbal Riven, Gilad Haran
Summary: ClpB protein's N-terminal domain has an unexpected autoinhibitory function, limiting the activity of its disaggregation machine. Binding of a substrate protein or the cochaperone DnaK can alleviate this inhibition.
ACS CHEMICAL BIOLOGY
(2021)
Article
Geochemistry & Geophysics
Xiang Li, Si Huang, Tubing Yin, Xibing Li, Kang Peng, Xiaodong Fan, Wengang Dang, Linchong Huang
Summary: The study investigated the effect of thermal shock on heated sandstone, with tests conducted under different cooling rates. It was found that the physical properties of heated sandstone change as the heating level increases. Higher cooling rates cause more damage to the sandstone, with different failure modes and mechanisms analyzed.
Article
Biochemistry & Molecular Biology
Manoj Thakur, Ankit Agarwal, Kalappa Muniyappa
Summary: The study explores the enzymatic properties of the Mycobacterium tuberculosis UvrABC excinuclease complex, revealing that MtUvrC has UvrB-independent ATPase activity which drives dual incision of damaged DNA strands. In contrast, EcUvrC lacks ATPase activity but retains the ability to bind ATP.
Article
Multidisciplinary Sciences
Christos S. Karamitros, Kyle Murray, Brent Winemiller, Candice Lamb, Everett M. Stone, Sheena D'Arcy, Kenneth A. Johnson, George Georgiou
Summary: The dynamic motions of enzymes have a significant impact on the reaction pathway. Mutations in enzymes can increase catalytic activity by affecting conformational flexibility and thereby modulating the rate of the chemical step.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Jianfeng Zhang, Georg Northoff
Summary: This article reviews the neural basis and functions of the global signal in the brain, showing its close coupling with physiological signals and its role in modulating arousal level, organizing a dynamic topography, and coordinating different forms of cognition. The findings suggest the need to go beyond considering the global signal as noise and embrace a dual-layer model with background and surface layers.
COMMUNICATIONS BIOLOGY
(2022)
Article
Physics, Multidisciplinary
Patricia Contreras-Tejada, Carlos Palazuelos, Julio de Vicente
Summary: The research shows that any network where parties are connected by bipartite pure entangled states is genuinely multipartite nonlocal, regardless of the amount of entanglement in the shared states and the network's topology. This paves the way for generating genuine multipartite nonlocality in connected networks.
PHYSICAL REVIEW LETTERS
(2021)