The Role of Human Centromeric RNA in Chromosome Stability

Conserved chromosomal functions of RNA interference

(2020) Michael J. Gutbrod et al.   NATURE REVIEWS GENETICS

cGAS-STING, an important pathway in cancer immunotherapy

(2020) Minlin Jiang et al.   Journal of Hematology & Oncology

ZFAT binds to centromeres to control noncoding RNA transcription through the KAT2B–H4K8ac–BRD4 axis

(2020) Shuhei Ishikura et al.   NUCLEIC ACIDS RESEARCH

Cell Cycle Checkpoints Cooperate to Suppress DNA- and RNA-Associated Molecular Pattern Recognition and Anti-Tumor Immune Responses

(2020) Jie Chen et al.   Cell Reports

R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

(2020) Prashant K. Mishra et al.   MOLECULAR BIOLOGY OF THE CELL

Point centromere activity requires an optimal level of centromeric noncoding RNA

(2019) Yick Hin Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

STING pathway agonism as a cancer therapeutic

(2019) Blake A. Flood et al.   IMMUNOLOGICAL REVIEWS

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

(2018) Georg O.M. Bobkov et al.   JOURNAL OF CELL BIOLOGY

Heterochromatin-Encoded Satellite RNAs Induce Breast Cancer

(2018) Quan Zhu et al.   MOLECULAR CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

RNAi is a critical determinant of centromere evolution in closely related fungi

(2018) Vikas Yadav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Regulation of cGAS

(2018) Meiguang Xiong et al.   VIROLOGICA SINICA

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing

(2018) Prasun Chakraborty et al.   Nature Communications

A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregation

(2017) Lilian Kabeche et al.   SCIENCE

Major satellite repeat RNA stabilize heterochromatin retention of Suv39h enzymes by RNA-nucleosome association and RNA:DNA hybrid formation

(2017) Oscar Velazquez Camacho et al.   eLife

RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

(2017) Whitney L Johnson et al.   eLife

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions

(2016) Yohei Niikura et al.   Cell Reports

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

(2016) Konstantina Rowald et al.   Cell Reports

Centromeric Transcription Regulates Aurora-B Localization and Activation

(2016) Michael D. Blower   Cell Reports

Regulation of Budding Yeast CENP-A levels Prevents Misincorporation at Promoter Nucleosomes and Transcriptional Defects

(2016) Erica M. Hildebrand et al.   PLoS Genetics

CENP-C is a blueprint for constitutive centromere–associated network assembly within human kinetochores

(2015) Kerstin Klare et al.   JOURNAL OF CELL BIOLOGY

Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation

(2015) Hong Liu et al.   MOLECULAR CELL

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

(2015) Rémi Buisson et al.   MOLECULAR CELL

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

(2015) Francesca Bersani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

RNAi pathway participates in chromosome segregation in mammalian cells

(2015) Chuan Huang et al.   Cell Discovery

The Centromere: Chromatin Foundation for the Kinetochore Machinery

(2014) Tatsuo Fukagawa et al.   DEVELOPMENTAL CELL

Involvement of satellite I noncoding RNA in regulation of chromosome segregation

(2014) Takashi Ideue et al.   GENES TO CELLS

Repetitive centromeric satellite RNA is essential for kinetochore formation and cell division

(2014) Silvana Rošić et al.   JOURNAL OF CELL BIOLOGY

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

(2014) Delphine Quénet et al.   eLife

Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution

(2013) Daniël P Melters et al.   GENOME BIOLOGY

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Active transcription and essential role of RNA polymerase II at the centromere during mitosis

(2012) F. L. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous Transcription at the Centromere Facilitates Centromere Activity in Budding Yeast

(2011) Kentaro Ohkuni et al.   CURRENT BIOLOGY

Identification of Noncoding Transcripts from within CENP-A Chromatin at Fission Yeast Centromeres

(2011) Eun Shik Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing

(2011) Quan Zhu et al.   NATURE

SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin

(2011) Christèle Maison et al.   NATURE GENETICS

Aberrant Overexpression of Satellite Repeats in Pancreatic and Other Epithelial Cancers

(2011) D. T. Ting et al.   SCIENCE

Asymmetric Distribution of Gene Expression in the Centromeric Region of Rice Chromosome 5

(2011) Hiroshi Mizuno et al.   Frontiers in Plant Science

Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeats

(2010) Kaalak Reddy et al.   NUCLEIC ACIDS RESEARCH

DNA Binding of Centromere Protein C (CENPC) Is Stabilized by Single-Stranded RNA

(2010) Yaqing Du et al.   PLoS Genetics

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

(2009) Federica Ferri et al.   NUCLEIC ACIDS RESEARCH

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCAN Makes Multiple Contacts with Centromeric DNA to Provide Distinct Pathways to the Outer Kinetochore

(2008) Tetsuya Hori et al.   CELL

A new class of retroviral and satellite encoded small RNAs emanates from mammalian centromeres

(2008) Dawn M. Carone et al.   CHROMOSOMA

Inactivation of a Human Kinetochore by Specific Targeting of Chromatin Modifiers

(2008) Megumi Nakano et al.   DEVELOPMENTAL CELL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE