Review
Biochemistry & Molecular Biology
Wangli Zheng, Nanhua Chen, Francois Meurens, Wanglong Zheng, Jianzhong Zhu
Summary: This study summarizes the mechanisms by which cGAS avoids sensing self-DNA under normal physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Le Yu, Pengda Liu
Summary: cGAS is a major cytosolic DNA sensor that, when hyperactivated, contributes to autoimmune diseases but serves as an adjuvant for anticancer immune therapy; inactivation of cGAS signaling causes difficulty in sensing and clearing infections, as well as facilitating tumor immune evasion, therefore cGAS activation is tightly controlled.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Chemistry, Medicinal
Jin Kyung Seok, Minhyuk Kim, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: cGAS is a DNA sensor that triggers a strong immune response, and its signaling pathway plays important roles in autoimmunity, inflammation, and cancer progression, making it an attractive therapeutic target. This review provides insights into the prevention and treatment of cGAS-related chronic immune and inflammatory diseases based on accumulated evidence.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Review
Immunology
Debipreeta Bhowmik, Fanxiu Zhu
Summary: Sensing viral constituents is crucial for host immune defense against viruses. Host DNA sensors have been discovered and their mechanisms elucidated, but herpesviruses employ diverse strategies to evade host DNA sensing.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O'Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Summary: The small molecule idronoxil inhibits the signalling of TBK1/IKK epsilon, a key signalling component involved in antiviral activities and pro-inflammatory responses. This finding highlights the critical role of TBK1/IKK epsilon signalling in SARS-CoV-2 hyper-inflammation.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Zhilei Wang, Nian Chen, Zhiyong Li, Guang Xu, Xiaoyan Zhan, Jianyuan Tang, Xiaohe Xiao, Zhaofang Bai
Summary: Inflammation is a protective response regulated by the host, with cGAS-STING pathway playing a crucial role in immune defense, viral infections, fatty liver, and cancer metastasis. The potential impact of this pathway in liver diseases has attracted widespread attention, with pharmacological agonists and antagonists offering new therapeutic possibilities. Understanding the mechanisms of cGAS-STING pathway may lead to the development of effective treatments for liver diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Summary: The study identifies abnormal DNA recognition and IFN-I production as drivers of severe ANCA-associated vasculitis, and demonstrates that blocking this pathway can ameliorate the disease and accelerate recovery, suggesting potential therapeutic targets for patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Wanglong Zheng, Anjing Liu, Nengwen Xia, Nanhua Chen, Francois Meurens, Jianzhong Zhu
Summary: The cGAS-STING signaling axis is activated by cytosolic DNA, both non-self and self DNA. This pathway is used by the innate immune system to monitor invading pathogens and/or damage. It not only facilitates inflammatory responses and IFN production, but also activates other cellular processes like apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Wanglong Zheng, Nengwen Xia, Jiajia Zhang, Nanhua Chen, Francois Meurens, Zongping Liu, Jianzhong Zhu
Summary: The cGAS-STING pathway is involved in triggering both canonical and non-canonical autophagy, which plays crucial roles in balancing innate immune responses, maintaining intracellular environmental homeostasis, alleviating liver injury, and limiting tumor growth and transformation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Thomas J. Hayman, Peter M. Glazer
Summary: Research on disease treatment has focused on DNA repair pathways, with potential for enhanced efficacy with novel immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Fisheries
Wenxian Zhu, Yuqiang Cheng, Zhaofei Wang, Likai Ji, Jingjiao Ma, Yaxian Yan, Hengan Wang, Jianhe Sun
Summary: Compared with mammals, chickens have an impaired innate immune system with key genes inactivated or missing. A predicted N-terminal deletion in the chicken Cyclic GMP-AMP synthase gene has been experimentally confirmed, but further experimental evidence is needed to verify its functional integrity.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wen Zhou, Lisa Mohr, John Maciejowski, Philip J. Kranzusch
Summary: The phase separation of cGAS-DNA is critical for efficient sensing of immunostimulatory DNA, as it limits the activity of the cytosolic exonuclease TREX1. This selective environment suppresses TREX1 function and restricts DNA degradation, balancing cytosolic DNA degradation and innate immune activation.
Review
Immunology
Min Zhang, Yan Zou, Xujun Zhou, Jinming Zhou
Summary: The cGAS-STING signaling pathway plays a significant role in the host immune response and its abnormal activation is closely related to autoimmune diseases. Targeting this pathway has become a promising strategy for therapy of autoimmune diseases. This review summarizes the key pathways and various autoimmune diseases mediated by the cGAS-STING-TBK1 axis, as well as recent developments in selective inhibitors of cGAS, STING, or TBK1 and their potential application in therapy of cGAS-STING-TBK1 related autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Qiuya Yu, Lei Chu, Yongxing Li, Quanyi Wang, Juanjuan Zhu, Chen Wang, Shufang Cui
Summary: The study reveals that during HSV-1 infection, miR-23a and miR-23b directly regulate cGAS expression through interaction with lncRNA Oasl2-209, and in the autoimmune disease model, miR-23a/b can mitigate self DNA-induced autoinflammatory responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Roberto Amadio, Giulia Maria Piperno, Federica Benvenuti
Summary: The activation of cellular responses to DNA acts as a defense mechanism, but uncontrolled response can lead to autoimmune diseases. Dysregulated recognition of self-DNA is associated with type-I interferons and ISGs, while fine-tuned membrane trafficking and cytoskeletal dynamics play crucial roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yong Ran, Jing Zhang, Li-Li Liu, Zhao-Yi Pan, Ying Nie, Hong-Yan Zhang, Yan-Yi Wang
JOURNAL OF MOLECULAR CELL BIOLOGY
(2016)
Article
Immunology
Tian-Tian Liu, Qing Yang, Mi Li, Bo Zhong, Yong Ran, Li-Li Liu, Yan Yang, Yan-Yi Wang, Hong-Bing Shu
JOURNAL OF IMMUNOLOGY
(2016)
Article
Cell Biology
Zhi-Sheng Xu, Hong-Xia Zhang, Yu-Long Zhang, Tian-Tian Liu, Yong Ran, Liu-Ting Chen, Yan-Yi Wang, Hong-Bing Shu
JOURNAL OF MOLECULAR CELL BIOLOGY
(2016)
Article
Microbiology
Ying Nie, Yong Ran, Hong-Yan Zhang, Zhe-Fu Huang, Zhao-Yi Pan, Su-Yun Wang, Yan-Yi Wang
Article
Microbiology
Qian Zhou, Heng Lin, Suyun Wang, Shuai Wang, Yong Ran, Ying Liu, Wen Ye, Xiaozhe Xiong, Bo Zhong, Hong-Bing Shu, Yan-Yi Wang
CELL HOST & MICROBE
(2014)
Review
Biochemistry & Molecular Biology
Yong Ran, Hong-Bing Shu, Yan-Yi Wang
CYTOKINE & GROWTH FACTOR REVIEWS
(2014)
Article
Cell Biology
He Chen, Ying Li, Jing Zhang, Yong Ran, Jin Wei, Yan Yang, Hong-Bing Shu
JOURNAL OF MOLECULAR CELL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Zhi-Sheng Xu, Hong-Xia Zhang, Wei-Wei Li, Yong Ran, Tian-Tian Liu, Mei-Guang Xiong, Qing-Lan Li, Su-Yun Wang, Min Wu, Hong-Bing Shu, Huimin Xia, Yan-Yi Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Immunology
Yong Ran, Mei-guang Xiong, Zhi-sheng Xu, Wei-wei Luo, Su-yun Wang, Yan-Yi Wang
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Mei-Guang Xiong, Zhi-Sheng Xu, Yu-Hui Li, Su-Yun Wang, Yan-Yi Wang, Yong Ran
Article
Microbiology
Hong-Yan Zhang, Bo-Wei Liao, Zhi-Sheng Xu, Yong Ran, Dong-Peng Wang, Yan Yang, Wei-Wei Luo, Yan-Yi Wang
Article
Multidisciplinary Sciences
Wei-Wei Li, Ying Nie, Yan Yang, Yong Ran, Wei-Wei Luo, Mei-Guang Xiong, Su-Yun Wang, Zhi-Sheng Xu, Yan-Yi Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Virology
Yu-Hui Li, Jiang-Ling Peng, Zhi-Sheng Xu, Mei-Guang Xiong, Huang-Ning Wu, Su-Yun Wang, Dan Li, Guo-Qiang Zhu, Yong Ran, Yan-Yi Wang
Summary: African swine fever virus (ASFV) is a large DNA virus that causes acute and hemorrhagic disease in pigs. In this study, researchers identified an ASFV cysteine protease pS273R as an antagonist of type I interferon (IFN). The pS273R protein inhibits the JAK-STAT signaling pathway triggered by type I IFNs, and its mechanism involves the degradation of STAT2 through ubiquitination.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Bo-Wei Liao, Hong-Yan Zhang, Wen-Tian Du, Yong Ran, Yan-Yi Wang, Zhi-Sheng Xu
Summary: IL-1β is a crucial mediator of inflammatory responses, and its signaling is finely regulated by various mechanisms. This study identified FAM177A1 as a negative regulator of IL-1β-induced signaling, which competitively binds to TRAF6 and impairs its downstream signaling cascade.
JOURNAL OF IMMUNOLOGY
(2021)