Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Sex Hormone Regulation of Proteins Modulating Mitochondrial Metabolism, Dynamics and Inter-Organellar Cross Talk in Cardiovascular Disease

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Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases

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Mitofusin 2 but not mitofusin 1 mediates Bcl-XL-induced mitochondrial aggregation

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Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury

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Expression Profile of microRNAs in Hypertrophic Cardiomyopathy and Effects of microRNA-20 in Inducing Cardiomyocyte Hypertrophy Through Regulating Gene MFN2

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Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2

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Mitochondrial fusion mediated by fusion promotion and fission inhibition directs adult mouse heart function toward a different direction

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Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset

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Mitoflash lights single mitochondrial dynamics events in mature cardiomyocytes

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Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model

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Mitofusin 2 Exerts a Protective Role in Ischemia Reperfusion Injury Through Increasing Autophagy

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The INs and OUTs of mitofusins

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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

(2018) Agostinho G. Rocha et al.   SCIENCE

Mitofusin 2: from functions to disease

(2018) Riccardo Filadi et al.   Cell Death & Disease

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

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A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space

(2017) Sevan Mattie et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

(2017) Verónica Eisner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The coming of age of the mitochondria–ER contact: a matter of thickness

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Mfn2 deficiency links age‐related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway

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Mitochondrial dynamics and cell death in heart failure

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Structures of human mitofusin 1 provide insight into mitochondrial tethering

(2016) Yuanbo Qi et al.   JOURNAL OF CELL BIOLOGY

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miR-106a promotes cardiac hypertrophy by targeting mitofusin 2

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Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal plasticity

(2016) A.M. Bertholet et al.   NEUROBIOLOGY OF DISEASE

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

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Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

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Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

Mitofusin-2-mediated tethering of mitochondria and endoplasmic reticulum promotes cell cycle arrest of vascular smooth muscle cells in G0/G1 phase

(2015) D. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

(2015) Weilin Wang et al.   CANCER LETTERS

Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA

(2015) Liang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

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Dysregulation of Mfn2 and Drp-1 proteins in heart failure

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Mitochondrial Genome Linearization Is a Causative Factor for Cardiomyopathy in Mice and Drosophila

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Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

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Anti-Tumor Effects of Mfn2 in Gastric Cancer

(2013) Ge-Er Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

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Mitochondrial Dynamics in Cardiovascular Health and Disease

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(2012) Gerald W. Dorn   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The intracellular redox state is a core determinant of mitochondrial fusion

(2012) Timothy Shutt et al.   EMBO REPORTS

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

(2012) Seungmin Lee et al.   HUMAN MOLECULAR GENETICS

Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes

(2012) Ting Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

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Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study

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SnapShot: Mitochondrial Quality Control

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Mitochondrial Fusion is Essential for Organelle Function and Cardiac Homeostasis

(2011) Yun Chen et al.   CIRCULATION RESEARCH

Mitofusin-2 Maintains Mitochondrial Structure and Contributes to Stress-Induced Permeability Transition in Cardiac Myocytes

(2011) K. N. Papanicolaou et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

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Mitofusin 2 Inhibits Angiotensin II-Induced Myocardial Hypertrophy

(2010) Haiyi Yu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma

(2010) Baiye Jin et al.   MEDICAL ONCOLOGY

Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells

(2010) Weilin Wang et al.   MEDICAL ONCOLOGY

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

(2010) Angela C. Poole et al.   PLoS One

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenovirus-expressed human hyperplasia suppressor gene induces apoptosis in cancer cells

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE