A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

Cellular Senescence in Neurodegenerative Diseases

(2020) Carmen Martínez-Cué et al.   Frontiers in Cellular Neuroscience

hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites

(2020) Yongchao Liu et al.   Cells

Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex

(2020) Hannah E. Salapa et al.   Annals of Clinical and Translational Neurology

Role of Poly [ADP-ribose] Polymerase 1 in Activating the Kirsten ras (KRAS) Gene in Response to Oxidative Stress

(2020) Giorgio Cinque et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Post-translational modifications of hnRNP A1 differentially modulate retroviral IRES-mediated translation initiation

(2020) Aldo Barrera et al.   NUCLEIC ACIDS RESEARCH

Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid–liquid phase separation and aggregation

(2020) Veronica H Ryan et al.   NUCLEIC ACIDS RESEARCH

Single-Molecule Imaging of mRNA Localization and Regulation during the Integrated Stress Response

(2019) Johannes H. Wilbertz et al.   MOLECULAR CELL

Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres

(2019) Tong-Hong Wang et al.   Cancers

Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis

(2019) Sangmin Lee et al.   PLoS One

Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma

(2019) Hao Yang et al.   ONCOGENE

IRES Trans-Acting Factors, Key Actors of the Stress Response

(2019) Anne-Claire Godet et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

(2019) Yongjia Duan et al.   CELL RESEARCH

HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells

(2019) Tatsuya Nishikawa et al.   Scientific Reports

Deep protein methylation profiling by combined chemical and immunoaffinity approaches reveals novel PRMT1 targets

(2019) Nicolas Hartel et al.   MOLECULAR & CELLULAR PROTEOMICS

Properties of Stress Granule and P-Body Proteomes

(2019) Ji-Young Youn et al.   MOLECULAR CELL

Antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1 contribute to neuronal cell loss in an animal model of multiple sclerosis

(2019) Cole D. Libner et al.   JOURNAL OF COMPARATIVE NEUROLOGY

LncRNA ANCR promotes hepatocellular carcinoma metastasis through upregulating HNRNPA1 expression

(2019) Zhili Wen et al.   RNA Biology

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

(2018) Jade-Emmanuelle Deshaies et al.   BRAIN

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

(2018) Sebastian Markmiller et al.   CELL

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

(2018) Lin Guo et al.   CELL

Mechanisms of protein toxicity in neurodegenerative diseases

(2018) Chang Geon Chung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The solvent side of proteinaceous membrane-less organelles in light of aqueous two-phase systems

(2018) Boris Y. Zaslavsky et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior

(2018) Titus Franzmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HnRNPA1 Specifically Recognizes the Base of Nucleotide at the Loop of RNA G-Quadruplex

(2018) Xiao Liu et al.   MOLECULES

Molecular epidemiological study of familial amyotrophic lateral sclerosis in Japanese population by whole-exome sequencing and identification of novel HNRNPA1 mutation

(2018) Hiroya Naruse et al.   NEUROBIOLOGY OF AGING

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

(2018) Eugenio Mercuri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ageing, Cellular Senescence and Neurodegenerative Disease

(2018) Marios Kritsilis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The molecular language of membraneless organelles

(2018) Edward Gomes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysfunctional RNA binding proteins and stress granules in multiple sclerosis

(2018) Hannah E. Salapa et al.   JOURNAL OF NEUROIMMUNOLOGY

RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain

(2018) Meenakshi Ghosh et al.   NUCLEIC ACIDS RESEARCH

Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

(2018) Dan Bracha et al.   CELL

Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

(2018) Ming-Chuan Hsu et al.   Cancers

The effect of O -GlcNAcylation on hnRNP A1 translocation and interaction with transportin1

(2017) Shira Roth et al.   EXPERIMENTAL CELL RESEARCH

Methylarginines within the RGG-Motif Region of hnRNP A1 Affect Its IRES Trans -Acting Factor Activity and Are Required for hnRNP A1 Stress Granule Localization and Formation

(2017) Michael L. Wall et al.   JOURNAL OF MOLECULAR BIOLOGY

Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy

(2017) Richard S. Finkel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7

(2017) Irene Beusch et al.   eLife

hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability

(2016) Hui Wang et al.   AGING CELL

Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2

(2016) Ja Hyun Koo et al.   GASTROENTEROLOGY

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

(2016) Jing Fang et al.   NATURE IMMUNOLOGY

Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS

(2016) Qing Liu et al.   NEUROLOGY

Principles and Properties of Stress Granules

(2016) David S.W. Protter et al.   TRENDS IN CELL BIOLOGY

Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells

(2015) So Jung Park et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

(2015) Siheng Xiang et al.   CELL

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

Regulation of RAGE splicing by hnRNP A1 and Tra2β-1 and its potential role in AD pathogenesis

(2015) Xiao-Yan Liu et al.   JOURNAL OF NEUROCHEMISTRY

Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease

(2015) Antonella Borreca et al.   MOLECULAR NEUROBIOLOGY

DNA-PKcs phosphorylates hnRNP-A1 to facilitate the RPA-to-POT1 switch and telomere capping after replication

(2015) Jiangdong Sui et al.   NUCLEIC ACIDS RESEARCH

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

Recognition and Binding of Human Telomeric G-Quadruplex DNA by Unfolding Protein 1

(2014) Jason S. Hudson et al.   BIOCHEMISTRY

hnRNP M facilitates exon 7 inclusion of SMN2 pre-mRNA in spinal muscular atrophy by targeting an enhancer on exon 7

(2014) Sunghee Cho et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling

(2014) Rajat Roy et al.   NUCLEIC ACIDS RESEARCH

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

(2014) Ahmed Moursy et al.   NUCLEIC ACIDS RESEARCH

Presynaptic Localization of Smn and hnRNP R in Axon Terminals of Embryonic and Postnatal Mouse Motoneurons

(2014) Benjamin Dombert et al.   PLoS One

Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration

(2013) Xing Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

(2013) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

hnRNP A1 and secondary structure coordinate alternative splicing of Mag

(2013) N. R. Zearfoss et al.   RNA

hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress

(2012) Fabrizio Damiano et al.   BIOCHEMICAL JOURNAL

Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

(2012) Amit Berson et al.   EMBO Molecular Medicine

Cross-Reactive Antibodies to Target Proteins are Dependent upon Oligomannose Glycosylated Epitopes in HTLV-1 Associated Neurological Disease

(2012) Sangmin Lee et al.   JOURNAL OF CLINICAL IMMUNOLOGY

HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence

(2012) Yoon Ha Choi et al.   NUCLEIC ACIDS RESEARCH

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Valproic acid increases SMN2 expression and modulates SF2/ASF and hnRNPA1 expression in SMA fibroblast cell lines

(2011) Indra Sari Kusuma Harahap et al.   BRAIN & DEVELOPMENT

MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1

(2011) Samira Ziaei et al.   EXPERIMENTAL CELL RESEARCH

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Phosphomimetic Substitution of Heterogeneous Nuclear Ribonucleoprotein A1 at Serine 199 Abolishes AKT-dependent Internal Ribosome Entry Site-transacting Factor (ITAF) Function via Effects on Strand Annealing and Results in Mammalian Target of Rapamycin Complex 1 (mTORC1) Inhibitor Sensitivity

(2011) Jheralyn Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A potential link between autoimmunity and neurodegeneration in immune-mediated neurological disease

(2011) Sangmin Lee et al.   JOURNAL OF NEUROIMMUNOLOGY

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA

(2011) Rachel Litman Flynn et al.   NATURE

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling

(2011) Sung Min Son et al.   NEUROBIOLOGY OF AGING

Role of hnRNP-A1 and miR-590-3p in Neuronal Death: Genetics and Expression Analysis in Patients with Alzheimer Disease and Frontotemporal Lobar Degeneration

(2011) Chiara Villa et al.   REJUVENATION RESEARCH

Quaking Regulates Hnrnpa1 Expression through Its 3′ UTR in Oligodendrocyte Precursor Cells

(2011) N. Ruth Zearfoss et al.   PLoS Genetics

SMN2 exon 7 splicing is inhibited by binding of hnRNP A1 to a common ESS motif that spans the 3′ splice site

(2010) Thomas Koed Doktor et al.   HUMAN MUTATION

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

p38 MAP Kinase-dependent regulation of the expression level and subcellular distribution of heterogeneous nuclear ribonucleoprotein A1 and its involvement in cellular senescence in normal human fibroblasts

(2010) Naoko Shimada et al.   RNA Biology

Human protein arginine methyltransferases in vivo - distinct properties of eight canonical members of the PRMT family

(2009) F. Herrmann et al.   JOURNAL OF CELL SCIENCE

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

(2009) Manikandan Paramasivam et al.   NUCLEIC ACIDS RESEARCH

hnRNP A1 and hnRNP H can collaborate to modulate 5' splice site selection

(2009) J.-F. Fisette et al.   RNA

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

(2008) Yimin Hua et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular mimicry in neurological disease: what is the evidence?

(2008) S. Lee et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B

(2008) Yaowu He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heterogeneous Nuclear Ribonucleoprotein A1 Regulates Cyclin D1 and c-mycInternal Ribosome Entry Site Function through Akt Signaling

(2008) Oak D. Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-translational glycosylation of target proteins implicate molecular mimicry in the pathogenesis of HTLV-1 associated neurological disease

(2008) S LEE et al.   JOURNAL OF NEUROIMMUNOLOGY

The RNA Binding Protein hnRNP Q Modulates the Utilization of Exon 7 in the Survival Motor Neuron 2 (SMN2) Gene

(2008) H.-H. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Autoimmune-induced preferential depletion of myelin-associated glycoprotein (MAG) is genetically regulated in relapsing EAE (B6 × SJL) F1 mice

(2008) Dusanka S Skundric et al.   Molecular Neurodegeneration