Arginine Metabolism and Its Potential in Treatment of Colorectal Cancer

L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221

(2020) Hexi Zhang et al.   Biomed Research International

MiR ‐302b‐5p enhances the neuroprotective effect of IGF ‐1 in methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced Parkinson's disease by regulating inducible nitric‐oxide synthase

(2020) Xiaorui Cui et al.   CELL BIOCHEMISTRY AND FUNCTION

Regulation of the Paneth cell niche by exogenous L ‐arginine couples the intestinal stem cell function

(2020) Qihang Hou et al.   FASEB JOURNAL

MicroRNA-1291-5p sensitizes pancreatic carcinoma cells to arginine deprivation and chemotherapy through the regulation of arginolysis and glycolysis

(2020) Mei-Juan Tu et al.   MOLECULAR PHARMACOLOGY

miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

(2020) Viviana Scalavino et al.   Scientific Reports

The importance of plasma arginine level and its downstream metabolites in diagnosing prostate cancer

(2019) Ismail Selvi et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Acute 4,4′-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages

(2019) Chen-Chung Lin et al.   TOXICOLOGICAL SCIENCES

A role for endothelial nitric oxide synthase in intestinal stem cell proliferation and mesenchymal colorectal cancer

(2018) Jon Peñarando et al.   BMC BIOLOGY

Upregulation of microRNA‑24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase

(2018) Huan‑Ting Li et al.   Molecular Medicine Reports

MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer

(2018) Yi Niu et al.   ONCOGENE

Involvement of methylation of MicroRNA-122, −125b and -106b in regulation of Cyclin G1, CAT-1 and STAT3 target genes in isoniazid-induced liver injury

(2018) Yuhong Li et al.   BMC Pharmacology & Toxicology

Alteration of microRNA 340-5p and Arginase-1 Expression in Peripheral Blood Cells during Acute Ischemic Stroke

(2018) Hanna Yoo et al.   MOLECULAR NEUROBIOLOGY

Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

(2018) Constantinos Alexandrou et al.   Scientific Reports

Ablation alleviates atrial fibrillation by regulating the signaling pathways of endothelial nitric oxide synthase/nitric oxide via miR-155-5p and miR-24-3p

(2018) Maojing Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages

(2018) Sandra Marcia Muxel et al.   Frontiers in Immunology

Arginase-2, a miR-1299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence-induced autophagy inhibition

(2017) Nan-Hyung Kim et al.   Pigment Cell & Melanoma Research

MicroRNA-613 is downregulated in HCMV-positive glioblastoma and inhibits tumour progression by targeting arginase-2

(2017) Yan Wang et al.   TUMOR BIOLOGY

Safflor yellow B reduces hypoxia-mediated vasoconstriction by regulating endothelial micro ribonucleic acid/nitric oxide synthase signaling

(2017) Chaoyun Wang et al.   Oncotarget

H2S regulates endothelial nitric oxide synthase protein stability by promoting microRNA-455-3p expression

(2017) Xing-Hui Li et al.   Scientific Reports

Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism

(2017) Sandra Marcia Muxel et al.   Scientific Reports

MicroRNA-26a-5p regulates the expression of inducible nitric oxide synthase via activation of NF-κB pathway in human osteoarthritis chondrocytes

(2016) Zafar Rasheed et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

(2016) Ilaria Marigo et al.   CANCER CELL

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma

(2016) Willy Hugo et al.   CELL

Arginine dependence of tumor cells: targeting a chink in cancer’s armor

(2016) M D Patil et al.   ONCOGENE

Silencing of argininosuccinate lyase inhibits colorectal cancer formation

(2016) Hau-Lun Huang et al.   ONCOLOGY REPORTS

Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase

(2016) Svetlana N. Reilly et al.   Science Translational Medicine

Role of Nitric Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and cGMP-Dependent Protein Kinase I in Mouse Stem Cell Cardiac Development

(2016) Valentina Spinelli et al.   Stem Cells International

Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection

(2016) Ibrahim M. Sektioglu et al.   OncoImmunology

Modulation bymiR-29bof intestinal epithelium homoeostasis through the repression of menin translation

(2015) Miao Ouyang et al.   BIOCHEMICAL JOURNAL

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

MicroRNA-155 modulates the proliferation of vascular smooth muscle cells by targeting endothelial nitric oxide synthase

(2015) JUN ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase

(2015) QIZHONG FU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Plasma levels of microRNA-24, microRNA-320a, and microRNA-423-5p are potential biomarkers for colorectal carcinoma

(2015) Zanxi Fang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

(2015) Jennifer Jung et al.   MOLECULAR AND CELLULAR BIOLOGY

Upregulation of microRNA-335 and microRNA-584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase

(2015) FENG JIANG et al.   Molecular Medicine Reports

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Argininosuccinate lyase is a potential therapeutic target in breast cancer

(2015) HAU-LUN HUANG et al.   ONCOLOGY REPORTS

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation

(2015) Muly Tham et al.   Oncotarget

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma

(2015) Ann M. Lozier et al.   Oncotarget

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells

(2014) Youpeng Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Circulating miR-378 in plasma: a reliable, haemolysis-independent biomarker for colorectal cancer

(2014) S Zanutto et al.   BRITISH JOURNAL OF CANCER

Clinical potential role of circulating microRNAs in early diagnosis of colorectal cancer patients

(2014) Mulong Du et al.   CARCINOGENESIS

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

(2014) Raghu R. Chivukula et al.   CELL

Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans

(2014) Soumen K. Manna et al.   GASTROENTEROLOGY

Arginine Enhances Osteoblastogenesis and Inhibits Adipogenesis through the Regulation of Wnt and NFATc Signaling in Human Mesenchymal Stem Cells

(2014) Jeong-Eun Huh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repression of Arginase-2 Expression in Dendritic Cells by MicroRNA-155 Is Critical for Promoting T Cell Proliferation

(2014) Isabelle Dunand-Sauthier et al.   JOURNAL OF IMMUNOLOGY

MiR-29b replacement inhibits proteasomes and disrupts aggresome+autophagosome formation to enhance the antimyeloma benefit of bortezomib

(2014) S Jagannathan et al.   LEUKEMIA

Elevated level of microRNA-21 in the serum of patients with colorectal cancer

(2014) Gholam Basati et al.   MEDICAL ONCOLOGY

MicroRNA-155 inhibits migration of trophoblast cells and contributes to the pathogenesis of severe preeclampsia by regulating endothelial nitric oxide synthase

(2014) XUELAN LI et al.   Molecular Medicine Reports

Circulating Exosomal microRNAs as Biomarkers of Colon Cancer

(2014) Hiroko Ogata-Kawata et al.   PLoS One

Identification of a Circulating MicroRNA Signature for Colorectal Cancer Detection

(2014) Jia Wang et al.   PLoS One

Arginine deprivation and autophagic cell death in cancer

(2014) Peter Wojciech Szlosarek   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

(2014) Chun A. Changou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigation of microRNA-155 as a serum diagnostic and prognostic biomarker for colorectal cancer

(2014) Zhong-chuan Lv et al.   TUMOR BIOLOGY

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

(2014) Melissa M. Phillips et al.   Cancer Research and Treatment

Polyamine catabolism in carcinogenesis: potential targets for chemotherapy and chemoprevention

(2013) Valentina Battaglia et al.   AMINO ACIDS

Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/ -Catenin Pathway in Colorectal Cancer

(2013) J. Camps et al.   CANCER RESEARCH

The Continuum of Cancer Immunosurveillance: Prognostic, Predictive, and Mechanistic Signatures

(2013) Jérôme Galon et al.   IMMUNITY

Overexpression of Human Arginine Decarboxylase Rescues Human Mesenchymal Stem Cells against H2O2 Toxicity through Cell Survival Protein Activation

(2013) Su Kyoung Seo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Inhibition of neuronal nitric oxide synthase activity promotes migration of human-induced pluripotent stem cell-derived neural stem cells toward cancer cells

(2013) Can Chen et al.   JOURNAL OF NEUROCHEMISTRY

NPM-ALK up-regulates iNOS expression through a STAT3/microRNA-26a-dependent mechanism

(2013) Haifeng Zhu et al.   JOURNAL OF PATHOLOGY

Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer

(2013) Yuji Toiyama et al.   JNCI-Journal of the National Cancer Institute

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis

(2013) Jia-Xing Zhang et al.   LANCET ONCOLOGY

Polyamines are oncometabolites that regulate the LIN28/let-7 pathway in colorectal cancer cells

(2013) Edwin A. Paz et al.   MOLECULAR CARCINOGENESIS

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

A colorectal cancer classification system that associates cellular phenotype and responses to therapy

(2013) Anguraj Sadanandam et al.   NATURE MEDICINE

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and Evaluation of Plasma MicroRNAs for Early Detection of Colorectal Cancer

(2013) Xiaoya Luo et al.   PLoS One

Overexpression of Arginine Transporter CAT-1 Is Associated with Accumulation of L-Arginine and Cell Growth in Human Colorectal Cancer Tissue

(2013) Ying Lu et al.   PLoS One

Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells

(2013) S. Mandal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum miR-21 and miR-92a as biomarkers in the diagnosis and prognosis of colorectal cancer

(2013) Guang-Hui Liu et al.   TUMOR BIOLOGY

Plasma MiR-21

(2012) Ziad Kanaan et al.   ANNALS OF SURGERY

Tumor-associated neutrophils: friend or foe?

(2012) Z. G. Fridlender et al.   CARCINOGENESIS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Arginine deficiency leads to impaired cofilin dephosphorylation in activated human T lymphocytes

(2012) Nadja Feldmeyer et al.   INTERNATIONAL IMMUNOLOGY

microRNAs in cancer management

(2012) Yi W Kong et al.   LANCET ONCOLOGY

A tumour suppressor network relying on the polyamine–hypusine axis

(2012) Claudio Scuoppo et al.   NATURE

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes

(2012) Z. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

l-Arginine is a Radioprotector for Hematopoietic Progenitor Cells

(2012) Linda L Pearce et al.   RADIATION RESEARCH

MicroRNA Replacement Therapy for miR-145 and miR-33a Is Efficacious in a Model of Colon Carcinoma

(2011) A. F. Ibrahim et al.   CANCER RESEARCH

Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment

(2011) P. Allavena et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer

(2011) Yanlei Ma et al.   GUT

Detection of miR-92a and miR-21 in stool samples as potential screening biomarkers for colorectal cancer and polyps

(2011) Chung Wah Wu et al.   GUT

Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells

(2011) Ge Ma et al.   IMMUNITY

SLC6A14 (ATB0,+) Protein, a Highly Concentrative and Broad Specific Amino Acid Transporter, Is a Novel and Effective Drug Target for Treatment of Estrogen Receptor-positive Breast Cancer

(2011) Senthil Karunakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intronic microRNA suppresses endothelial nitric oxide synthase expression and endothelial cell proliferation via inhibition of STAT3 signaling

(2011) Limei Yan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hepato-specific microRNA-122 facilitates accumulation of newly synthesized miRNA through regulating PRKRA

(2011) Shuai Li et al.   NUCLEIC ACIDS RESEARCH

Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

(2011) A. C. Goodwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Inducible Nitric Oxide Synthase Expression in the Mouse Renal Cell Carcinoma Cell Line RENCA Is Mediated by MicroRNA miR-146a

(2010) Christina Perske et al.   AMERICAN JOURNAL OF PATHOLOGY

Simultaneous determination of l-citrulline and l-arginine in plasma by high performance liquid chromatography

(2010) Hui-ming Mao et al.   CLINICAL BIOCHEMISTRY

Colorectal cancer molecular biology moves into clinical practice

(2010) C. C. Pritchard et al.   GUT

Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

(2010) Barbara Delage et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating miR-221 directly amplified from plasma is a potential diagnostic and prognostic marker of colorectal cancer and is correlated with p53 expression

(2010) Xing-xiang Pu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Intratumoral macrophage counts correlate with tumor progression in colorectal cancer

(2010) Jung-Cheng Kang et al.   JOURNAL OF SURGICAL ONCOLOGY

Colorectal cancer

(2010) David Cunningham et al.   LANCET

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

Arginine: Master and Commander in Innate Immune Responses

(2010) S. M. Morris   Science Signaling

MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging

(2009) David J. Bates et al.   AGING CELL

Worldwide Variations in Colorectal Cancer

(2009) M. M. Center et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

International Trends in Colorectal Cancer Incidence Rates

(2009) M. M. Center et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

Disrupting Polyamine Homeostasis as a Therapeutic Strategy for Neuroblastoma

(2009) N. F. Evageliou et al.   CLINICAL CANCER RESEARCH

Combination Chemoprevention for Colon Cancer Targeting Polyamine Synthesis and Inflammation

(2009) E. W. Gerner et al.   CLINICAL CANCER RESEARCH

Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening

(2009) E K O Ng et al.   GUT

Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer

(2009) Zhaohui Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Human Embryonic Stem Cells Suppress T Cell Responses via Arginase I-Dependent Mechanism

(2009) N. Yachimovich-Cohen et al.   JOURNAL OF IMMUNOLOGY

Nitric oxide and TNF-  trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

(2009) S. E. Erdman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine metabolism and nutrition in growth, health and disease

(2008) Guoyao Wu et al.   AMINO ACIDS

Arginine Deprivation as a Targeted Therapy for Cancer

(2008) L. Feun et al.   CURRENT PHARMACEUTICAL DESIGN

MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma

(2008) Aaron J. Schetter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tumour maintenance is mediated by eNOS

(2008) Kian-Huat Lim et al.   NATURE