BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

(2021) Ondrej Belan et al.   MOLECULAR CELL

ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

(2020) Jacob Paiano et al.   Nature Communications

Mutational signatures are jointly shaped by DNA damage and repair

(2020) Nadezda V. Volkova et al.   Nature Communications

Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination

(2020) Kazumasa Takemoto et al.   Cell Reports

Meiotic Double-Strand Break Processing and Crossover Patterning Are Regulated in a Sex-Specific Manner by BRCA1-BARD1 in Caenorhabditis elegans

(2020) Qianyan Li et al.   GENETICS

BRCA1-associated structural variations are a consequence of polymerase theta-mediated end-joining

(2020) J. A. Kamp et al.   Nature Communications

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

(2019) Tatiana Garcia-Muse et al.   Cell Reports

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

Defining the influence of Rad51 and Dmc1 lineage-specific amino acids on genetic recombination

(2019) Justin B. Steinfeld et al.   GENES & DEVELOPMENT

A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination

(2018) Ana María León-Ortiz et al.   MOLECULAR CELL

Essential Role of BRCA2 in Ovarian Development and Function

(2018) Ariella Weinberg-Shukron et al.   NEW ENGLAND JOURNAL OF MEDICINE

BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis

(2018) Eva Janisiw et al.   PLoS Genetics

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

(2018) Qianyan Li et al.   PLoS Genetics

Ovarian Aging in Women With BRCA Germline Mutations

(2017) Wayne Lin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation

(2016) Stephen Gray et al.   Annual Review of Genetics

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BRCA2 regulates DMC1-mediated recombination through the BRC repeats

(2016) Juan S. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meiotic recombination and the crossover assurance checkpoint in Caenorhabditis elegans

(2016) Zhouliang Yu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance

(2016) Marlène Jagut et al.   PLOS BIOLOGY

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis

(2016) Ye Hong et al.   PLoS Genetics

REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation inCaenorhabditis elegans

(2015) George Chung et al.   GENES & DEVELOPMENT

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

Recombination, Pairing, and Synapsis of Homologs during Meiosis

(2015) Denise Zickler et al.   Cold Spring Harbor Perspectives in Biology

An Overview of the Molecular Mechanisms of Recombinational DNA Repair

(2015) Stephen C. Kowalczykowski   Cold Spring Harbor Perspectives in Biology

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage

(2014) Sarah J. Hill et al.   GENES & DEVELOPMENT

Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

(2014) Srilatha Simhadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis

(2014) Tyler J. Broering et al.   JOURNAL OF CELL BIOLOGY

53BP1, BRCA1, and the Choice between Recombination and End Joining at DNA Double-Strand Breaks

(2014) J. M. Daley et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanism and Regulation of Meiotic Recombination Initiation

(2014) Isabel Lam et al.   Cold Spring Harbor Perspectives in Biology

DNA Strand Exchange and RecA Homologs in Meiosis

(2014) M. Scott Brown et al.   Cold Spring Harbor Perspectives in Biology

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

(2014) Andrés Cruz-García et al.   Cell Reports

Interplay between Structure-Specific Endonucleases for Crossover Control during Caenorhabditis elegans Meiosis

(2013) Takamune T. Saito et al.   PLoS Genetics

COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers

(2012) Rayka Yokoo et al.   CELL

The role of BRCA1 in DNA double-strand repair: Past and present

(2012) Kevin W. Caestecker et al.   EXPERIMENTAL CELL RESEARCH

Crossover Distribution and Frequency Are Regulated by him-5 in Caenorhabditis elegans

(2012) P. M. Meneely et al.   GENETICS

Links between genome integrity and BRCA1 tumor suppression

(2012) Mischa L. Li et al.   TRENDS IN BIOCHEMICAL SCIENCES

SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Caenorhabditis elegans Germline

(2012) Takamune T. Saito et al.   PLoS Genetics

Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2

(2011) Noriko Hosoya et al.   EMBO REPORTS

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

(2011) Valerie Garcia et al.   NATURE

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

(2011) Nicolas Siaud et al.   PLoS Genetics

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

xnd-1 regulates the global recombination landscape in Caenorhabditis elegans

(2010) Cynthia R. Wagner et al.   NATURE

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

(2009) Aura Carreira et al.   CELL

BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes

(2009) A. Kouznetsova et al.   JOURNAL OF CELL SCIENCE

Association of BRCA1 Mutations With Occult Primary Ovarian Insufficiency: A Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks

(2009) Kutluk Oktay et al.   JOURNAL OF CLINICAL ONCOLOGY

The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange

(2009) M. K. K. Shivji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair

(2008) Adele Adamo et al.   EMBO REPORTS

Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

(2008) David Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

(2008) Shantha K. Mahadevaiah et al.   JOURNAL OF CELL BIOLOGY

Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination

(2008) Claire L. Hartley et al.   MOLECULAR MICROBIOLOGY

Drosophila brca2 Is Required for Mitotic and Meiotic DNA Repair and Efficient Activation of the Meiotic Recombination Checkpoint

(2008) Martha Klovstad et al.   PLoS Genetics