Journal
PLOS BIOLOGY
Volume 14, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.1002412
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Funding
- FWF [SFB-F34, P-23638-B12, W1238, P-28464-B28]
- Vienna International Post-Doctoral Program in Molecular Life Sciences (VIPS)
- NIH [NIH R01 GM067268, 1S10OD01227601]
- FWF Erwin Schrodinger Fellowship [J-3676]
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- Austrian Science Fund (FWF) [W1238, W1207] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [J 3676, P 23638] Funding Source: researchfish
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During the first meiotic division, crossovers (COs) between homologous chromosomes ensure their correct segregation. COs are produced by homologous recombination (HR)-mediated repair of programmed DNA double strand breaks (DSBs). As more DSBs are induced than COs, mechanisms are required to establish a regulated number of COs and to repair remaining intermediates as non-crossovers (NCOs). We show that the Caenorhabditis elegans RMI1 homolog-1 (RMH-1) functions during meiosis to promote both CO and NCO HR at appropriate chromosomal sites. RMH-1 accumulates at CO sites, dependent on known pro-CO factors, and acts to promote CO designation and enforce the CO outcome of HR-intermediate resolution. RMH-1 also localizes at NCO sites and functions in parallel with SMC-5 to antagonize excess HR-based connections between chromosomes. Moreover, RMH-1 also has a major role in channeling DSBs into an NCO HR outcome near the centers of chromosomes, thereby ensuring that COs form predominantly at off-center positions.
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