CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

(2020) Charles P. Couturier et al.   Nature Communications

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

(2020) Soniya Bastola et al.   Nature Communications

Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation

(2019) Mutsuko Minata et al.   Cell Reports

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

(2019) Vadim Le Joncour et al.   EMBO Molecular Medicine

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

The phenotypes of proliferating glioblastoma cells reside on a single axis of variation

(2019) Lin Wang et al.   Cancer Discovery

Proinflammatory Mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and Thrombin Directly Induce Capillary Tube Regression

(2019) Gretchen M. Koller et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting the perivascular niche in brain tumors

(2018) Giorgio Seano   CURRENT OPINION IN ONCOLOGY

CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo

(2018) Shinji Mii et al.   GENES TO CELLS

Revealing the glioma cancer stem cell interactome, one niche at a time

(2018) Daniel J Silver et al.   JOURNAL OF PATHOLOGY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis

(2017) Chen-Hua Chuang et al.   NATURE MEDICINE

The role of the NG2 proteoglycan in OPC and CNS network function

(2016) Dominik Sakry et al.   BRAIN RESEARCH

GlioVis data portal for visualization and analysis of brain tumor expression datasets

(2016) Robert L. Bowman et al.   NEURO-ONCOLOGY

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

IGFBP2 potentiates nuclear EGFR–STAT3 signaling

(2015) C Y Chua et al.   ONCOGENE

The Human Glioblastoma Cell Culture Resource: Validated Cell Models Representing All Molecular Subtypes

(2015) Yuan Xie et al.   EBioMedicine

Polysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas

(2014) Katri Mäkelä et al.   BMC CANCER

Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells

(2014) Mario L. Suvà et al.   CELL

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Epidermal Hyperplasia and Appendage Abnormalities in Mice Lacking CD109

(2012) Shinji Mii et al.   AMERICAN JOURNAL OF PATHOLOGY

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

(2012) Piia-Riitta Karhemo et al.   Journal of Proteomics

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

The TGF-β co-receptor, CD109, promotes internalization and degradation of TGF-β receptors

(2011) Albane A. Bizet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CD109 release from the cell surface in human keratinocytes regulates TGF-β receptor expression, TGF-β signalling and STAT3 activation: relevance to psoriasis

(2011) Ivan V. Litvinov et al.   EXPERIMENTAL DERMATOLOGY

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

(2011) Simon A. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Processing of CD109 by furin and its role in the regulation of TGF-β signaling

(2010) S Hagiwara et al.   ONCOGENE

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

CD109 expression in basal-like breast carcinoma

(2008) Masaki Hasegawa et al.   PATHOLOGY INTERNATIONAL