Review
Cell Biology
Ke Zhou
Summary: A polysaccharides-based cell wall plays a crucial role in shaping and protecting plant cells. Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are involved in the regulation of cell wall, acting as structural components and being responsible for organizing cellulose microfibrils. They also participate in cell wall integrity signaling transduction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Weiming Wang, Khanghy Truong, Chaobaihui Ye, Suman Sharma, Huan He, Lihong Liu, Michael Wen, Anisha Misra, Paul Zhou, Jason T. Kimata
Summary: In this study, GPI-scFv X5 was found to block cell-cell transmission of HIV-1 from DCs to target cells and neutralize HIV-1 replication in iDCs, suggesting its potential as an immunotherapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Pauliina Filppu, Jayendrakishore Tanjore Ramanathan, Kirsi J. Granberg, Erika Gucciardo, Hannu Haapasalo, Kaisa Lehti, Matti Nykter, Vadim Le Joncour, Pirjo Laakkonen
Summary: The CD109/STAT3 axis is crucial for maintaining the stemness and tumorigenicity of glioma stem cells (GSCs) and mediating chemoresistance. Targeting this axis could potentially overcome therapy resistance in glioblastoma.
Article
Oncology
Mikoto Tanabe, Kohei Hosokawa, Mai Anh Thi Nguyen, Noriharu Nakagawa, Kana Maruyama, Noriaki Tsuji, Ryota Urushihara, Luis Espinoza, Mahmoud Elbadry, Md Mohiuddin, Takamasa Katagiri, Masanori Ono, Hiroshi Fujiwara, Kazuhisa Chonabayashi, Yoshinori Yoshida, Hirohito Yamazaki, Atsushi Hirao, Shinji Nakao
Summary: CD109 suppresses TGF-beta signaling in HSPCs, and the lack of CD109 may increase the sensitivity of PIGA-mutated HSPCs to TGF-beta, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated BM failure.
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Piotr K. Zakrzewski
Summary: Endometrial cancer is a major gynecological cancer among women in their menopausal and postmenopausal age, and the canonical TGF beta pathway plays a crucial role in its development and progression. The TGF beta cascade can act as both a tumor suppressor and tumor promoter, with its effects on endometrial cancer cells depending on the cancer disease stage.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Shasha Liu, Chaoqi Zhang, Boqiao Wang, Huanyu Zhang, Guohui Qin, Congcong Li, Ling Cao, Qun Gao, Yu Ping, Kai Zhang, Jingyao Lian, Qitai Zhao, Dan Wang, Zhen Zhang, Xuan Zhao, Li Yang, Lan Huang, Bo Yang, Yi Zhang
Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Medicine, General & Internal
Megumi Kishimoto, Mayumi Komine, Miho Sashikawa-Kimura, Tuba Musarrat Ansary, Koji Kamiya, Junichi Sugai, Makiko Mieno, Hirotoshi Kawata, Ryutaro Sekimoto, Noriyoshi Fukushima, Mamitaro Ohtsuki
Summary: This study did not find a significant difference in STAT3 activation between psoriasis patients and the control group in three types of cancer. The results suggest that psoriasis patients do not have a predisposition to STAT3 activation, indicating that STAT3 activation is intricately regulated by each disorder or cellular microenvironment in both cancer and psoriasis. However, due to limitations in sample size and inconsistency in cancer histology and differentiation, further research is needed to verify these conclusions.
Article
Biochemistry & Molecular Biology
Zongcheng Lin, Fei Xie, Marina Trivino, Tao Zhao, Frederik Coppens, Lieven Sterck, Maurice Bosch, Vernonica E. Franklin-Tong, Moritz K. Nowack
Summary: In this study, the researchers identified the key role of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in self-incompatibility (SI) in plants. They discovered the HLD1/AtPGAP1 gene as a critical component required for SI response and demonstrated its function as a GPI-inositol deacylase.
Article
Cardiac & Cardiovascular Systems
Christophe Guignabert, Laurent Savale, Athenais Boucly, Raphael Thuillet, Ly Tu, Mina Ottaviani, Christopher J. Rhodes, Pascal De Groote, Gregoire Prevot, Emmanuel Bergot, Arnaud Bourdin, Luke S. Howard, Elie Fadel, Antoine Beurnier, Anne Roche, Mitja Jevnikar, Xavier Jais, David Montani, Martin R. Wilkins, Olivier Sitbon, Marc Humbert
Summary: Activin A and FSTL3 serum levels are associated with transplant-free survival in PAH. They can serve as prognostic biomarkers for PAH, and their diagnostic values have been confirmed in an independent validation cohort. The activin signaling system in PAH involves phosphorylated Smad2/3 nuclear accumulation and differential immunoreactivities of various proteins in vascular endothelial and smooth muscle layers.
Article
Medicine, Research & Experimental
Corina M. Borza, Gema Bolas, Fabian Bock, Xiuqi Zhang, Favour C. Akabogu, Ming-Zhi Zhang, Mark de Caestecker, Min Yang, Haichun Yang, Ethan Lee, Leslie Gewin, Agnes B. Fogo, W. Hayes McDonald, Roy Zent, Ambra Pozzi
Summary: DDR1 plays an important role in both acute and chronic kidney injury by regulating the phosphorylation of BCR and STAT3, affecting the production of MCP-1 and TGF-beta.
Article
Pharmacology & Pharmacy
Ni Made Dwi Sandhiutami, Wawaimuli Arozal, Melva Louisa, Deni Rahmat, Puspita Eka Wuyung
Summary: The combination of cisplatin and nanocurcumin significantly reduced ovarian tumor volume and weight in rat models, while also inhibiting the expression of proliferation-related proteins and activation of signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Mo Jie, Zhao-Qi Zhang, Ning Deng, Qiu-Meng Liu, Chao Wang, Qian-Yun Ge, Peng-Chen Du, Sha-Sha Song, Xue-Wu Zhang, Long-Xin, Hui-Fang Liang, Liang Chu, Lei Mang, Xiao-Ping Chen, Jin Chen, Han-Hua Dong, Bi-Xiang Zhang
Summary: 18 beta-glycyrrhetinic acid (GA) inhibits TGF-beta-induced epithelial-mesenchymal transition (EMT) and metastasis of hepatocellular carcinoma (HCC) cells by reducing the phosphorylation of signal transducer and activator of transcription 3 (STAT3). This provides a potential therapeutic target for HCC management.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Immunology
D. Alejandro Canaria, Bingyu Yan, Maia G. Clare, Zonghao Zhang, Grace A. Taylor, David L. Boone, Majid Kazemian, Matthew R. Olson
Summary: Th9 cells, which produce IL-9, have dual roles in immunity against parasites and cancers as well as in the pathogenesis of allergic diseases and colitis. The differentiation of Th9 cells is regulated by IL-2-induced STAT5 signaling, which is vital for chromatin accessibility within Il9 loci. In allergic disease, Th9 cells exhibit a gene repression signature associated with a Th17-like phenotype, suggesting a balance between these two T cell subsets controlled by IL-2/STAT5 signaling.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Article
Oncology
Eliana-Ruobing Zhang, Sarah Ghezelbash, Pingxing Xie, Misha Fotovati, Ivan Litvinov, Philippe Lefrancois
Summary: Basal cell carcinoma (BCC) is the most common form of skin cancer, with a small percentage being aggressive and having different immune profiles and stem cell populations. Currently, there is no reliable model for advanced BCC. This study used genomic data from various tumors to identify three cancers with similar immune cell composition to BCC, in order to gain insights for potential treatments and model development.
Review
Dermatology
Alex Nguyen, Pingxing Xie, Ivan V. Litvinov, Philippe Lefrancois
Summary: This study reviewed the latest clinical trials and studies on the efficacy and safety of sonic hedgehog inhibitors (SSHis) in the treatment of advanced basal cell carcinoma (BCC). The results showed that SSHis are effective in treating advanced BCC, but patients may experience adverse effects. Therefore, managing patient expectations and ensuring long-term treatment compliance is essential.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Energy & Fuels
Sergey Skripkin, Daniil Suslov, Ivan Plokhikh, Mikhail Tsoy, Evgeny Gorelikov, Ivan Litvinov
Summary: This article proposes a tool that uses machine learning algorithms to predict the frequency response of an unsteady vortex phenomenon, the precessing vortex core (PVC), occurring in a conical diffuser behind a radial swirler. The tool shows high accuracy in predicting the emergence of the PVC and predicting the frequency and power of pressure pulsations with low error.
Review
Biochemistry & Molecular Biology
Domenico Arcuri, Brandon Ramchatesingh, Francois Lagace, Lisa Iannattone, Elena Netchiporouk, Philippe Lefrancois, Ivan V. Litvinov
Summary: Actinic keratosis, a common skin disease, can be life-threatening if left untreated. Pharmacologic agents such as nicotinamide, acitretin, and 5-fluorouracil (5-FU) are used in prevention and treatment of AKs. 5-FU is considered the most effective therapy, but lower concentrations may also be effective. Uncertainty remains regarding the optimal treatment for immunocompetent vs. immunodeficient/immunosuppressed patients. Photodynamic light therapy is also an accepted treatment strategy for AKs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Aaron M. M. Drucker, Omer Kleiner, Rachael Manion, Anie Philip, Jan Dutz, Kathleen Barnard, Julie Fradette, Lucie Germain, Robert Gniadecki, Ivan Litvinov, Sarvesh Logsetty, Morris Manolson, P. Regine Mydlarski, Vincent Piguet, Debbie Ward, Youwen Zhou, An-Wen Chan
Summary: The Skin Investigation Network of Canada (SkIN Canada) identified the top ten research priorities for nine key skin conditions through surveys, scoping reviews, and workshops, emphasizing the importance of involving patients and healthcare providers.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Letter
Dermatology
Catherine Zhu, Sofianne Gabrielli, Lauren Khoury, Mohamed Osman, Ivan V. Litvinov, Lisa Iannattone, Philippe Lefrancois, Elena Netchiporouk
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Oncology
Sauliha Alli, Jonathan Lebeau, Agustina Hasbani, Francois Lagace, Ivan V. Litvinov, Sandra Pelaez
Summary: This study investigated the relationship between sun exposure and melanoma incidence rates in different provinces of Atlantic Canada and found that residents in provinces with higher incidence rates demonstrated greater sun exposure awareness and protective measures, but also received more sun exposure due to warmer climates and outdoor activities. Conversely, residents in provinces with lower incidence rates used sunscreen and protective clothing less frequently, engaged in occupations and hobbies with less sun exposure, and lived in cooler climates. This suggests a possible sunscreen paradox, where increased sunscreen use is correlated with higher sun exposure, leading to a false sense of security.
Review
Oncology
Santina Conte, Ammar Saed Aldien, Sebastien Jette, Jonathan LeBeau, Sauliha Alli, Elena Netchiporouk, Francois Lagace, Philippe Lefrancois, Lisa Iannattone, Ivan V. Litvinov
Summary: Incidence rates of melanoma and keratinocyte skin cancers have been rising globally. The lack of legislation to support individuals' protection from harmful UV radiation is a concern. Our comprehensive review found that only Australia has banned tanning beds for all ages. Occupational UVR exposure is not sufficiently recognized in workplace policies, and few protective measures are in place. Legislation and standardization are lacking in youth guidelines, and only Australia and select US jurisdictions have exempted sunscreen products from sales tax. We propose recommendations to reduce skin cancer rates, including promoting vitamin D supplementation alongside sun protective practices.
Article
Oncology
Badria Alkazemi, Feras M. Ghazawi, Francois Lagace, Vladimir Nechaev, Andrei Zubarev, Ivan V. Litvinov
Summary: This study analyzed the epidemiology of sarcomas in Canada and found that overall incidence decreased during the study period, but some subtypes showed increasing incidence. Axially located sarcomas had higher mortality rates compared to peripherally located sarcomas. Clustering of Kaposi sarcoma cases was observed in LGBTQ+ communities and postal codes with higher proportions of African-Canadian and Hispanic populations. Additionally, lower socioeconomic status postal codes had higher Kaposi sarcoma incidence rates.
Article
Medicine, General & Internal
Sarah J. Touyz, Feras M. Ghazawi, Elena Netchiporouk, Gizelle Popradi, Rene P. Michel, Sonia Skamene, Christine Lambert, Tarek Hijal, Ivan Litvinov
Summary: Cutaneous T-cell lymphomas are a type of non-Hodgkin lymphomas in which malignant T cells infiltrate the skin. The pathogenesis of these lymphomas is not completely understood, but persistent antigen stimulation of CD4+ memory T cells in the skin, combined with an inflammatory tissue environment rich in cytokines, may play a critical role. This case report demonstrates that primary cutaneous T-cell lymphoma can develop locally at the site of injury or surgery within a relatively short period of time. It contributes to the literature on cutaneous T-cell lymphomas arising after trauma, surgery, or a foreign body.
SAGE OPEN MEDICAL CASE REPORTS
(2023)
Letter
Dermatology
Catherine Zhu, Sofianne Gabrielli, Lauren Khoury, Mohamed Osman, Ivan V. Litvinov, Lisa Iannattone, Philippe Lefrancois, Elena Netchiporouk
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)
