Hypoxia and viral infectious diseases

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Does the pathogenesis of SARS-CoV-2 virus decrease at high-altitude?

(2020) Christian Arias-Reyes et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Oxygen: viral friend or foe?

(2020) Esther Shuyi Gan et al.   Virology Journal

Hypoxic microenvironment shapes HIV-1 replication and latency

(2020) Xiaodong Zhuang et al.   Communications Biology

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

(2020) Lydia J. Finney et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes

(2020) Esther Shuyi Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxygen Sensing and Viral Replication: Implications for Tropism and Pathogenesis

(2020) Peter Jianrui Liu et al.   Viruses-Basel

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

(2020) Jinsung Yang et al.   Nature Communications

Corticosteroids for COVID-19: the search for an optimum duration of therapy

(2020) Gyanshankar P Mishra et al.   Lancet Respiratory Medicine

The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control

(2019) Yangyang Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

(2019) Sung Hoon Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncolytic Virus Combination Therapy: Killing One Bird with Two Stones

(2018) Nikolas Tim Martin et al.   MOLECULAR THERAPY

Tumors in von Hippel–Lindau Syndrome: From Head to Toe—Comprehensive State-of-the-Art Review

(2018) Dhakshinamoorthy Ganeshan et al.   RADIOGRAPHICS

The HIF and other quandaries in VHL disease

(2017) D Tarade et al.   ONCOGENE

Development of Inhibitors Targeting Hypoxia-Inducible Factor 1 and 2 for Cancer Therapy

(2017) Tianchi Yu et al.   YONSEI MEDICAL JOURNAL

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

(2017) Yael Gropper et al.   Cell Reports

Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

(2017) Richard J. Kraus et al.   PLoS Pathogens

How Viruses Invade Cells

(2016) Fredric S. Cohen   BIOPHYSICAL JOURNAL

Pathways for Oxygen Regulation and Homeostasis

(2016) William G. Kaelin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Hypoxia-dependent regulation of inflammatory pathways in immune cells

(2016) Cormac T. Taylor et al.   JOURNAL OF CLINICAL INVESTIGATION

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond

(2015) Patrick H. Maxwell et al.   Nature Reviews Nephrology

Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar

(2014) Khin Saw Aye et al.   HUMAN PATHOLOGY

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors

(2013) Woondong Jeong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Role of cellular iron and oxygen in the regulation of HIV-1 infection

(2013) Sergei Nekhai et al.   Future Virology

The Natural Inhibitor of DNA Topoisomerase I, Camptothecin, Modulates HIF-1  Activity by Changing miR Expression Patterns in Human Cancer Cells

(2013) D. Bertozzi et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen

(2013) Andrew L Doedens et al.   NATURE IMMUNOLOGY

A mechanism for induction of a hypoxic response by vaccinia virus

(2013) M. Mazzon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxygen tension level and human viral infections

(2013) Frédéric Morinet et al.   VIROLOGY

Understanding and altering cell tropism of vesicular stomatitis virus

(2013) Eric Hastie et al.   VIRUS RESEARCH

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

(2012) Yan Xia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Low Oxygen Tension Enhances Hepatitis C Virus Replication

(2012) N. Vassilaki et al.   JOURNAL OF VIROLOGY

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors

(2011) R. P. Veeranna et al.   JOURNAL OF VIROLOGY

Role of HIF-1α in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells

(2009) Ruifeng Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

T-Cell Activation under Hypoxic Conditions Enhances IFN-γ Secretion

(2009) Jessica Roman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Development of HIF-1 inhibitors for cancer therapy

(2009) Barbara Onnis et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dexamethasone impairs hypoxia-inducible factor-1 function

(2008) A.E. Wagner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection

(2008) Helene A. Haeberle et al.   PLoS One