Dengue virus induces PCSK9 expression to alter antiviral responses and disease outcomes

Novel strategies to target PCSK9: beyond monoclonal antibodies

(2019) Nabil G Seidah et al.   CARDIOVASCULAR RESEARCH

Dengue

(2019) Annelies Wilder-Smith et al.   LANCET

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

(2019) Ali Ben Djoudi Ouadda et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

(2018) Saranya Sridhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Pathways Underlying Cholesterol Homeostasis

(2018) Milessa Silva Afonso et al.   Nutrients

Tropism of Dengue Virus in Mice and Humans Defined by Viral Nonstructural Protein 3-Specific Immunostaining

(2018) Scott J. Balsitis et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

(2018) R. Blake Richardson et al.   Nature Microbiology

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

(2018) Gregory G. Schwartz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

(2017) Seonghwan Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease

(2017) Marc S. Sabatine et al.   NEW ENGLAND JOURNAL OF MEDICINE

DENV up-regulates the HMG-CoA reductase activity through the impairment of AMPK phosphorylation: A potential antiviral target

(2017) Rubén Soto-Acosta et al.   PLoS Pathogens

Cardiovascular safety and efficacy of the PCSK9 inhibitor evolocumab in patients with and without diabetes and the effect of evolocumab on glycaemia and risk of new-onset diabetes: a prespecified analysis of the FOURIER randomised controlled trial

(2017) Marc S Sabatine et al.   Lancet Diabetes & Endocrinology

Dengue NS1 antigen contributes to disease severity by inducing interleukin (IL)-10 by monocytes

(2016) T. N. Adikari et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The anti-dengue virus properties of statins may be associated with alterations in the cellular antiviral profile expression

(2016) Owen Lloyd Bryan-Marrugo et al.   Molecular Medicine Reports

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

(2016) George Savidis et al.   Cell Reports

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

(2016) Henry Puerta-Guardo et al.   PLoS Pathogens

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

A Comparison of the Mouse and Human Lipoproteome: Suitability of the Mouse Model for Studies of Human Lipoproteins

(2015) Scott M. Gordon et al.   JOURNAL OF PROTEOME RESEARCH

Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

(2015) Jennifer G. Robinson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dengue virus NS1 triggers endothelial permeability and vascular leak that is prevented by NS1 vaccination

(2015) P. Robert Beatty et al.   Science Translational Medicine

Lower Low-Density Lipoprotein Cholesterol Levels Are Associated with Severe Dengue Outcome

(2015) Hope H. Biswas et al.   PLoS Neglected Tropical Diseases

Effect of Alirocumab, a Monoclonal Proprotein Convertase Subtilisin/Kexin 9 Antibody, on Lipoprotein(a) Concentrations (a Pooled Analysis of 150 mg Every Two Weeks Dosing from Phase 2 Trials)

(2014) Daniel Gaudet et al.   AMERICAN JOURNAL OF CARDIOLOGY

PCSK9

(2014) Nabil G. Seidah et al.   CIRCULATION RESEARCH

Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar

(2014) Khin Saw Aye et al.   HUMAN PATHOLOGY

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Lovastatin Delays Infection and Increases Survival Rates in AG129 Mice Infected with Dengue Virus Serotype 2

(2014) Marlen Martinez-Gutierrez et al.   PLoS One

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Determination of Viremia and Concentration of Circulating Nonstructural Protein 1 in Patients Infected with Dengue Virus in Mexico

(2013) Sergio I. de la Cruz-Hernández et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Dengue

(2012) Cameron P. Simmons et al.   NEW ENGLAND JOURNAL OF MEDICINE

G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication

(2012) Caroline Le Sommer et al.   PLoS Neglected Tropical Diseases

Clinical Relevance and Discriminatory Value of Elevated Liver Aminotransferase Levels for Dengue Severity

(2012) Linda K. Lee et al.   PLoS Neglected Tropical Diseases

Statins Reduce Dengue Virus Production via Decreased Virion Assembly

(2011) Marlén Martínez-Gutierrez et al.   INTERVIROLOGY

Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection

(2011) K. R. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship between Nonstructural Protein 1 Detection and Plasma Virus Load in Dengue Patients

(2010) Laurent Thomas et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites

(2009) Sonja Welsch et al.   Cell Host & Microbe

Discovery of insect and human dengue virus host factors

(2009) October M. Sessions et al.   NATURE