Staphylococcus aureus membrane vesicles contain immunostimulatory DNA, RNA and peptidoglycan that activate innate immune receptors and induce autophagy

Transcriptome Profiling of Staphylococcus aureus Associated Extracellular Vesicles Reveals Presence of Small RNA-Cargo

(2021) Bishnu Joshi et al.   Frontiers in Molecular Biosciences

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

(2020) Xiaogang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staphylococcus aureus secretes immunomodulatory RNA and DNA via membrane vesicles

(2020) Blanca V. Rodriguez et al.   Scientific Reports

Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) in Salmonella enterica Serovar Typhi

(2019) Jan Nevermann et al.   Frontiers in Microbiology

Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production

(2019) Benjamin I. Baarda et al.   PLoS Pathogens

AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles

(2019) Truc T. Losier et al.   Cell Reports

Back Cover: Helicobacter pylori Growth Stage Determines the Size, Protein Composition, and Preferential Cargo Packaging of Outer Membrane Vesicles

(2019) Lauren Zavan et al.   PROTEOMICS

Microbe-Host Communication by Small RNAs in Extracellular Vesicles: Vehicles for Transkingdom RNA Transportation

(2019) Heon-Jin Lee   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toll-like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles derived from Acinetobacter baumannii

(2019) Chad R. Marion et al.   INFECTION AND IMMUNITY

Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic Treatment

(2019) Uchini S. Kosgodage et al.   Frontiers in Cellular and Infection Microbiology

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF-α production in human macrophages and cross the blood–brain barrier in mice

(2019) Eun-Chong Han et al.   FASEB JOURNAL

Morbidity from in-hospital complications is greater than treatment failure in patients with Staphylococcus aureus bacteraemia

(2018) Natasha E. Holmes et al.   BMC INFECTIOUS DISEASES

Release of Staphylococcus aureus extracellular vesicles and their application as a vaccine platform

(2018) Xiaogang Wang et al.   Nature Communications

Helicobacter pylori Outer Membrane Vesicle Size Determines Their Mechanisms of Host Cell Entry and Protein Content

(2018) Lorinda Turner et al.   Frontiers in Immunology

Staphylococcus aureus Extracellular Vesicles Elicit an Immunostimulatory Response in vivo on the Murine Mammary Gland

(2018) Natayme R. Tartaglia et al.   Frontiers in Cellular and Infection Microbiology

The RNA Complement of Outer Membrane Vesicles From Salmonella enterica Serovar Typhimurium Under Distinct Culture Conditions

(2018) Antoine Malabirade et al.   Frontiers in Microbiology

Importance of phosphoinositide binding by human β-defensin 3 for Akt-dependent cytokine induction

(2017) Thanh Kha Phan et al.   IMMUNOLOGY AND CELL BIOLOGY

Secretable Small RNAs via Outer Membrane Vesicles in Periodontal Pathogens

(2017) J.-W. Choi et al.   JOURNAL OF DENTAL RESEARCH

Vancomycin-induced biofilm formation by methicillin-resistant Staphylococcus aureus is associated with the secretion of membrane vesicles

(2017) Xinlong He et al.   MICROBIAL PATHOGENESIS

Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis

(2017) Masanori Toyofuku et al.   Nature Communications

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury

(2017) Martina Bielaszewska et al.   PLoS Pathogens

Bacterial membrane vesicles transport their DNA cargo into host cells

(2017) Natalie J. Bitto et al.   Scientific Reports

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

Isolation and Characterization of a microRNA-size Secretable Small RNA in Streptococcus sanguinis

(2016) Ji-Woong Choi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Bacterial membrane vesicles: Biogenesis, immune regulation and pathogenesis

(2016) Rishi D. Pathirana et al.   CELLULAR MICROBIOLOGY

Proteomic analysis of outer membrane proteins and vesicles of a clinical isolate and a collection strain of Stenotrophomonas maltophilia

(2016) Mario Ferrer-Navarro et al.   Journal of Proteomics

A Two-Component Regulatory System Impacts Extracellular Membrane-Derived Vesicle Production in Group A Streptococcus

(2016) Ulrike Resch et al.   mBio

A novel mechanism for the biogenesis of outer membrane vesicles in Gram-negative bacteria

(2016) Sandro Roier et al.   Nature Communications

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

(2016) Katja Koeppen et al.   PLoS Pathogens

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

Differential Responses of Pattern Recognition Receptors to Outer Membrane Vesicles of Three Periodontal Pathogens

(2016) Jessica D. Cecil et al.   PLoS One

Uropathogenic Escherichia coli Releases Extracellular Vesicles That Are Associated with RNA

(2016) Cherie Blenkiron et al.   PLoS One

Bacterial RNA: An Underestimated Stimulus for Innate Immune Responses

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

Outer membrane vesicles isolated from two clinical Acinetobacter baumannii strains exhibit different toxicity and proteome characteristics

(2015) Zhi-Tao Li et al.   MICROBIAL PATHOGENESIS

Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi

(2015) Lisa Brown et al.   NATURE REVIEWS MICROBIOLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

The extracellular RNA complement ofEscherichia coli

(2015) Anubrata Ghosal et al.   MicrobiologyOpen

Functional Advantages of Porphyromonas gingivalis Vesicles

(2015) Meng-Hsuan Ho et al.   PLoS One

Gene Transfer Potential of Outer Membrane Vesicles of Acinetobacter baylyi and Effects of Stress on Vesiculation

(2014) Shweta Fulsundar et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Immune Receptor NOD1 and Kinase RIP2 Interact with Bacterial Peptidoglycan on Early Endosomes to Promote Autophagy and Inflammatory Signaling

(2014) Aaron T. Irving et al.   Cell Host & Microbe

Super-infection withStaphylococcus aureusinhibits influenza virus-induced type I IFN signalling through impaired STAT1-STAT2 dimerization

(2014) Kathrin Warnking et al.   CELLULAR MICROBIOLOGY

Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity

(2014) Yanlong Jiang et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against β-lactam antibiotics

(2014) Régis Stentz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Streptococcus mutans Extracellular DNA Is Upregulated during Growth in Biofilms, Actively Released via Membrane Vesicles, and Influenced by Components of the Protein Secretion Machinery

(2014) S. Liao et al.   JOURNAL OF BACTERIOLOGY

Extracellular vesicles produced by the Gram-positive bacteriumBacillus subtilisare disrupted by the lipopeptide surfactin

(2014) Lisa Brown et al.   MOLECULAR MICROBIOLOGY

Outer Membrane Vesicles Mediate Transport of Biologically Active Vibrio cholerae Cytolysin (VCC) from V. cholerae Strains

(2014) Sridhar Elluri et al.   PLoS One

Analysis of the Small RNA Transcriptional Response in Multidrug-Resistant Staphylococcus aureus after Antimicrobial Exposure

(2013) Benjamin P. Howden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Staphylococcus aureus Extracellular Vesicles Carry Biologically Active β-Lactamase

(2013) Jaewook Lee et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Type of Outer Membrane Vesicle Produced by the Gram-Negative Bacterium Shewanella vesiculosa M7T: Implications for DNA Content

(2013) Carla Pérez-Cruz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responses

(2013) Ryoma Nakao et al.   MICROBES AND INFECTION

Staphylococcus aureus α-Toxin-Dependent Induction of Host Cell Death by Membrane-Derived Vesicles

(2013) Bernard Thay et al.   PLoS One

Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses

(2012) M.-R. Kim et al.   ALLERGY

Horizontal Transfer of the OXA-24 Carbapenemase Gene via Outer Membrane Vesicles: a New Mechanism of Dissemination of Carbapenem Resistance Genes in Acinetobacter baumannii

(2011) Carlos Rumbo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analysis of microRNA-size, small RNAs in Streptococcus mutans by deep sequencing

(2011) Heon-Jin Lee et al.   FEMS MICROBIOLOGY LETTERS

NOD-Like Receptor Activation by Outer Membrane Vesicles fromVibrio choleraeNon-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

(2011) H. Bielig et al.   INFECTION AND IMMUNITY

Reduced Vancomycin Susceptibility in Staphylococcus aureus, Including Vancomycin-Intermediate and Heterogeneous Vancomycin-Intermediate Strains: Resistance Mechanisms, Laboratory Detection, and Clinical Implications

(2010) B. P. Howden et al.   CLINICAL MICROBIOLOGY REVIEWS

Staphylococcal Peptidoglycan Co-Localizes with Nod2 and TLR2 and Activates Innate Immune Response via Both Receptors in Primary Murine Keratinocytes

(2010) Maria Anna Müller-Anstett et al.   PLoS One

Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins

(2010) J. Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery of foreign antigens by engineered outer membrane vesicle vaccines

(2010) D. J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B Cell Activation by Outer Membrane Vesicles—A Novel Virulence Mechanism

(2010) Maria Laura A. Perez Vidakovics et al.   PLoS Pathogens

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles

(2009) Eun-Young Lee et al.   PROTEOMICS

Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-κB in mammary epithelial cells and to quickly induce TNFα and interleukin-8 (CXCL8) expression in the udder

(2008) Wei Yang et al.   MOLECULAR IMMUNOLOGY