Article
Biochemistry & Molecular Biology
Qun Zhao, Xinran Cheng, Jian Guo, Yun Bi, Li Kuang, Jianhua Ren, Jing Zhong, Longrui Pan, Xudong Zhang, Yang Guo, Yongqiang Liu, Shu Jin, Yan Tan, Xianjun Yu
Summary: MLKL plays a suppressive role in intestinal tumorigenesis by inhibiting the IL-6/JAK2/STAT3 signaling pathway, reducing the risk of intestinal tumor development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Takahiro Hamoya, Gen Fujii, Yosuke Iizumi, Takumi Narita, Masami Komiya, Yui Matsuzawa, Kohei Miki, Tadashi Kondo, Shinji Kishimoto, Kenji Watanabe, Keiji Wakabayashi, Toshiyuki Sakai, Jiro Toshima, Michihiro Mutoh
Summary: Artesunate inhibits intestinal tumorigenesis by reducing the nuclear translocation of TCF/LEF transcription factors, thereby suppressing Wnt signaling.
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaoke Huang, Jing Fang, Weiqi Lai, Yu Hu, Liang Li, Yuanyou Zhong, Shiwei Yang, Dan He, Rui Liu, Qingfeng Tang
Summary: This study demonstrates that treatment with IL-6 activates fructose uptake and fructolysis in oral squamous cell carcinoma (OSCC) cells and prostate cancer cells. Mechanistically, the transcription factor STAT3 associates with the Glut5 promoter region and enhances Glut5 transcription in response to IL-6 treatment. Knockdown of Glut5 attenuates IL-6-induced tumor cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kibrom M. Alula, Yaritza Delgado-Deida, Dakota N. Jackson, K. Venuprasad, Arianne L. Theiss
Summary: PHB1 plays a role in inhibiting the Wnt/β-catenin pathway to influence the development of intestinal tumorigenesis by regulating AXIN1 expression and the beta-catenin destruction complex. Induction of nuclear PHB1 trafficking provides a novel therapeutic option to influence AXIN1 expression and the beta-catenin destruction complex in Wnt-driven intestinal tumorigenesis.
Article
Biochemistry & Molecular Biology
Fangteng Liu, Nassim Bouznad, Markus Kaller, Xiaolong Shi, Janine Koenig, Stephanie Jaeckel, Heiko Hermeking
Summary: This study demonstrates the importance of miR-34a-mediated suppression of CSF1R in intestinal tumors, with the loss of miR-34a leading to increased adenoma formation and decreased survival, as well as increased proliferation, signaling pathways, and fibroblast infiltration. Deletion of Csf1r has opposite effects, suggesting that therapeutic targeting of CSF1R may be effective for CRC treatment with defects in the p53/miR-34a pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sultan Alhayyani, Louise McLeod, Alison C. West, Jesse J. Balic, Christopher Hodges, Liang Yu, Julian A. Smith, Zdenka Prodanovic, Steven Bozinovski, Beena Kumar, Saleela M. Ruwanpura, Mohamed I. Saad, Brendan J. Jenkins
Summary: The oncogenic potential of the STAT3 transcription factor in many human cancers, including lung cancer, is largely attributed to its nuclear activity as a tyrosine-phosphorylated transcription factor. However, an alternate pool of serine-phosphorylated STAT3 in mitochondria has been shown to promote tumorigenesis in a limited number of mutant RAS-addicted neoplasms. In mutant KRAS-driven lung adenocarcinoma, the transcriptional activity of pS(727)-STAT3 is essential for promoting a hyper-proliferative state in cancer cells through metabolic reprogramming.
Article
Hematology
Moses M. Kasembeli, Efiyenia Kaparos, Uddalak Bharadwaj, Ahmad Allaw, Alain Khouri, Bianca Acot, David J. Tweardy
Summary: STAT3 mutations in the DNA-binding domain and Src-homology 2 domain have been found to cause immunodeficiency, malignancy, and autoimmunity. The study reveals that these mutations affect the stability of STAT3 monomer and homodimer, as well as its activation processes. Specifically, mutations in the DNA-binding domain result in reduced DNA binding, while mutations in the Src-homology 2 domain lead to increased DNA binding. Furthermore, mutations related to immunodeficiency show decreased conformational stability, affecting various activation events. Interventions targeting these mutations may have therapeutic potential.
Article
Medicine, Research & Experimental
Ryoko Semba, Takamitsu Morioka, Hiromi Yanagihara, Kenshi Suzuki, Hirotaka Tachibana, Takahiro Hamoya, Yoshiya Horimoto, Tatsuhiko Imaoka, Mitsue Saito, Shizuko Kakinuma, Masami Arai
Summary: This study found that the macrolide antibiotic azithromycin has inhibitory effects on intestinal tumorigenesis in mice with a nonsense mutation in the Apc gene. It suppresses tumor growth and adenocarcinoma formation, while also restoring the levels of full-length Apc protein and downregulating β-catenin and cyclin D1. However, the impact of azithromycin on the diversity of intestinal microbiota depends on the concentration used.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Siru Zhou, Qinggang Dai, Xiangru Huang, Anting Jin, Yiling Yang, Xinyi Gong, Hongyuan Xu, Xin Gao, Lingyong Jiang
Summary: The study found that inactivation of STAT3 in osteoblasts can induce AD-HIES-like skeletal defects, while pharmacological activation of STAT3 can rescue this phenotype. STAT3 cooperates with MSX1 to drive osteoblast differentiation, indicating the importance of STAT3 in modulating skeletal development and maintaining bone homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Olusola O. Faluyi, Mark A. Hull, Alexander F. Markham, Constanze Bonifer, P. Louise Coletta
Summary: Advanced colorectal cancer requires new treatment strategies, with most MMR-proficient CRC showing resistance to checkpoint inhibitor therapy. Further studies are needed to determine the impact of immune surveillance on colorectal adenomas or MMR-proficient CRC resistance to CKI therapy.
Article
Immunology
Kosuke Miyauchi, Sewon Ki, Masao Ukai, Yoshie Suzuki, Kentaro Inoue, Wataru Suda, Takeshi Matsui, Yoshihiro Ito, Kenya Honda, Haruhiko Koseki, Osamu Ohara, Reiko J. Tanaka, Mariko Okada-Hatakeyama, Masato Kubo
Summary: The study suggests that STAT3 signaling in keratinocytes is essential for maintaining skin homeostasis by negatively regulating the expression of hair follicle-specific keratin genes. Expression patterns associated with dermatitis onset were observed under specific conditions, indicating the involvement of Toll-like receptor-mediated inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Yun Liu, Shijie Liao, Samuel Bennett, Haijun Tang, Dezhi Song, David Wood, Xinli Zhan, Jiake Xu
Summary: STAT3, a key protein involved in cell growth, differentiation, and survival, is overexpressed in osteosarcoma and various cancers. Its constitutive activation leads to upregulation of oncogenes, affecting processes such as transformation, proliferation, and metastasis.
CELL PROLIFERATION
(2021)
Article
Oncology
Danfei Liu, Xiangyuan Luo, Meng Xie, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Yijun Wang, Yangyang Feng, Xiaoyu Ji, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xia
Summary: The study reveals the clinical value, functional role, and molecular mechanism of heterogeneous nuclear ribonucleoprotein C (HNRNPC) in hepatocellular carcinoma (HCC), highlighting its potential as a biomarker for diagnosis, prognosis, and therapeutic targets.