Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer

Unphosphorylated STAT3 in heterochromatin formation and tumor suppression in lung cancer

(2020) Pranabananda Dutta et al.   BMC CANCER

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity

(2019) Jesse Balic et al.   CANCER RESEARCH

Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor

(2018) Matthew R. Janes et al.   CELL

Clinical Utility of a STAT3-Regulated miRNA-200 Family Signature with Prognostic Potential in Early Gastric Cancer

(2018) Liang Yu et al.   CLINICAL CANCER RESEARCH

KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target

(2018) Marta Román et al.   Molecular Cancer

STAT3 is a master regulator of epithelial identity and KRAS-driven tumorigenesis

(2018) Stephen D'Amico et al.   GENES & DEVELOPMENT

Toll‐like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

(2018) You Dong Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

(2018) Mauricio S. Caetano et al.   Nature Communications

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

Correlation between p-STAT3 overexpression and prognosis in lung cancer: A systematic review and meta-analysis

(2017) Mengting Tong et al.   PLoS One

Incidence and mortality of lung cancer: global trends and association with socioeconomic status

(2017) Martin C. S. Wong et al.   Scientific Reports

IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis

(2016) G. D. Brooks et al.   CANCER RESEARCH

Mitochondrial STAT3: Powering up a potent factor

(2016) Daniel J. Garama et al.   CYTOKINE

Next-generation EGFR/HER tyrosine kinase inhibitors for the treatment of patients with non-small-cell lung cancer harboring EGFR mutations: a review of the evidence

(2016) Xiaochun Wang et al.   OncoTargets and Therapy

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

(2016) Geou-Yarh Liou et al.   Cell Reports

Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion

(2015) Chunhua Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity

(2015) Kiyoshi Hirahara et al.   IMMUNITY

The Influence of the Evolution of First-Line Chemotherapy on Steadily Improving Survival in Advanced Non-Small-Cell Lung Cancer Clinical Trials

(2015) Krista L. Noonan et al.   Journal of Thoracic Oncology

Association of CCND1 overexpression with KRAS and PTEN alterations in specific subtypes of non-small cell lung carcinoma and its influence on patients’ outcome

(2015) Miodrag Dragoj et al.   TUMOR BIOLOGY

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

(2015) Beatrice Grabner et al.   Nature Communications

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

(2015) Valeria Poli et al.   Frontiers in Oncology

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation

(2014) S. Zhu et al.   BLOOD

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation

(2014) D. J. Gough et al.   BLOOD

Stat3 Binds to mtDNA and Regulates Mitochondrial Gene Expression in Keratinocytes

(2014) Everardo Macias et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Differential roles of STAT3 in the initiation and growth of lung cancer

(2014) J Zhou et al.   ONCOGENE

Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit

(2014) Z. Zhu et al.   Cancer Discovery

IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

(2014) M. Oft   Cancer Immunology Research

Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation

(2013) Fouad A Zouein et al.   HYPERTENSION RESEARCH

The enigmatic ERH protein: its role in cell cycle, RNA splicing and cancer

(2013) Meng-Tzu Weng et al.   Protein & Cell

STAT3 activation and aberrant ligand-dependent sonic hedgehog signaling in human pulmonary adenocarcinoma

(2012) Qin Yang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

(2011) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer

(2011) M. C. Garassino et al.   ANNALS OF ONCOLOGY

Clinical impact of phosphorylated signal transducer and activator of transcription 3, epidermal growth factor receptor, p53, and vascular endothelial growth factor receptor 1 expression in resected adenocarcinoma of lung by using tissue microarray

(2010) Hyeong Su Kim et al.   CANCER

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Signal Transducer and Activator of Transcription 3 Is Required for Hypoxia-Inducible Factor-1  RNA Expression in Both Tumor Cells and Tumor-Associated Myeloid Cells

(2008) G. Niu et al.   MOLECULAR CANCER RESEARCH

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas

(2008) Phuoc T. Tran et al.   PLoS One