The Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Complexity of the Tumor Microenvironment and Its Role in Acute Lymphoblastic Leukemia: Implications for Therapies
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-05-05
DOI
10.3389/fonc.2021.673506
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Phase I Study of Escalating Doses of Carfilzomib with HyperCVAD in Patients with Newly Diagnosed Acute Lymphoblastic Leukemia
- (2021) Brian A. Jonas et al. AMERICAN JOURNAL OF HEMATOLOGY
- Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop
- (2021) Lucine Fahy et al. Blood Advances
- miRNAs as Influencers of Cell–Cell Communication in Tumor Microenvironment
- (2020) Ilaria Conti et al. Cells
- Can VEGFR-3 be a better tumor marker for breast cancer than CA 15-3?
- (2020) Monika Zajkowska et al. ACTA BIOCHIMICA POLONICA
- Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults
- (2020) Anand A. Patel et al. CURRENT TREATMENT OPTIONS IN ONCOLOGY
- Anti-leukemic effects of histone deacetylase (HDAC) inhibition in acute lymphoblastic leukemia (ALL) cells: Shedding light on mitigating effects of NF-κB and autophagy on panobinostat cytotoxicity
- (2020) Mahdieh Mehrpouri et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Characterizing Lymphangiogenesis and Concurrent Inflammation in Adipose Tissue in Response to VEGF-D
- (2020) Adri Chakraborty et al. Frontiers in Physiology
- Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies
- (2020) Lia Walcher et al. Frontiers in Immunology
- SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine
- (2020) Tamara Rothenburger et al. Communications Biology
- Targeting mTOR in Acute Lymphoblastic Leukemia
- (2019) Carolina Simioni et al. Cells
- Relapsed T Cell ALL: Current Approaches and New Directions
- (2019) Christine M. McMahon et al. Current Hematologic Malignancy Reports
- Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B‑cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3
- (2019) Ting Yuan et al. Oncology Letters
- Adrenergic Modulation of Hematopoiesis
- (2019) Georges J. M. Maestroni Journal of Neuroimmune Pharmacology
- Leukemia-derived exosomes and cytokines pave the way for entry into the brain
- (2019) Ichiko Kinjyo et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Knockdown of the CXCL12/CXCR7 chemokine pathway results in learning deficits and neural progenitor maturation impairment in mice
- (2019) Françoise Trousse et al. BRAIN BEHAVIOR AND IMMUNITY
- OBI-3424, a novel AKR1C3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALL
- (2019) Kathryn Evans et al. CLINICAL CANCER RESEARCH
- Hematopoietic stem cells
- (2019) Zhenrui Li et al. CURRENT OPINION IN HEMATOLOGY
- Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later
- (2019) Pawel Robak et al. Drugs in research & development
- Imaging and spatial analysis of hematopoietic stem cell niches
- (2019) Alvaro Gomariz et al. Annals of the New York Academy of Sciences
- Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer
- (2019) Bhagyashri Kulkarni et al. DRUG DISCOVERY TODAY
- HIF-1α is overexpressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia
- (2019) Valentina Griggio et al. HAEMATOLOGICA
- Overexpression of heme oxygenase‐1 in microenvironment mediates vincristine resistance of B‐cell acute lymphoblastic leukemia by promoting vascular endothelial growth factor secretion
- (2019) Kunlin Yu et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Anti-Leukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia
- (2019) Sankaranarayanan Kannan et al. MOLECULAR CANCER THERAPEUTICS
- NEW BIOMARKERS AND THERAPEUTIC STRATEGIES IN ACUTE LYMPHOBLASTIC LEUKEMIAS: RECENT ADVANCES
- (2019) Carolina Simioni et al. HEMATOLOGICAL ONCOLOGY
- T-cell acute lymphoblastic leukemia displays autocrine production of Interleukin-7
- (2019) Anne Buffière et al. ONCOGENE
- Nanoparticles for Manipulation of the Developmental Wnt, Hedgehog, and Notch Signaling Pathways in Cancer
- (2019) D. M. Valcourt et al. ANNALS OF BIOMEDICAL ENGINEERING
- Tumor angiogenesis: causes, consequences, challenges and opportunities
- (2019) Roberta Lugano et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Treatment of children with relapsed and refractory acute lymphoblastic leukemia with mitoxantrone, vincristine, pegaspargase, dexamethasone, and bortezomib
- (2019) Keith J. August et al. PEDIATRIC BLOOD & CANCER
- Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme
- (2019) Lynn Jena et al. Drug Delivery and Translational Research
- Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes
- (2019) Lauren K. Meyer et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting signalling pathways and the immune microenvironment of cancer stem cells — a clinical update
- (2019) Joseph A. Clara et al. Nature Reviews Clinical Oncology
- Oxidative stress in normal hematopoietic stem cells and leukemia
- (2018) Azin Samimi et al. APMIS
- T cell acute lymphoblastic leukemia (T-ALL): New insights into the cellular origins and infiltration mechanisms common and unique among hematologic malignancies
- (2018) Eduardo Vadillo et al. BLOOD REVIEWS
- Targeting the microenvironment in solid tumors
- (2018) Carmen Belli et al. CANCER TREATMENT REVIEWS
- Blood Development: Hematopoietic Stem Cell Dependence and Independence
- (2018) Elaine Dzierzak et al. Cell Stem Cell
- Clinical Pharmacokinetics and Pharmacodynamics of Bortezomib
- (2018) Carlyn Rose C. Tan et al. CLINICAL PHARMACOKINETICS
- Bortezomib in Kidney Transplant: Current Use and Perspectives
- (2018) Lucio R. Requiao-Moura et al. CURRENT DRUG METABOLISM
- Role of CXCL12 and CXCR4 in the pathogenesis of hematological malignancies
- (2018) Amnon Peled et al. CYTOKINE
- Characterization of a new B-ALL cell line with constitutional defect of the Notch signaling pathway
- (2018) Paul Takam Kamga et al. Oncotarget
- The safety of bortezomib for the treatment of multiple myeloma
- (2018) Guldane Cengiz Seval et al. Expert Opinion On Drug Safety
- Immune cell subset differentiation and tissue inflammation
- (2018) Pu Fang et al. Journal of Hematology & Oncology
- Spotlight on Bortezomib: potential in the treatment of hepatocellular carcinoma
- (2018) I-Tao Huang et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy
- (2018) Chulin Sha et al. JOURNAL OF CLINICAL ONCOLOGY
- Continuing challenges and current issues in acute lymphoblastic leukemia
- (2017) Ankit Kansagra et al. LEUKEMIA & LYMPHOMA
- Combination of bortezomib and daunorubicin in the induction of apoptosis in T-cell acute lymphoblastic leukemia
- (2017) Xin Du et al. Molecular Medicine Reports
- Interleukin-7 signaling as a therapeutic target in acute lymphoblastic leukemia
- (2017) Angela Maria Savino et al. Expert Review of Hematology
- The hypoxia signalling pathway in haematological malignancies
- (2017) Marta Irigoyen et al. Oncotarget
- Quantifying the effects of antiangiogenic and chemotherapy drug combinations on drug delivery and treatment efficacy
- (2017) Sirin Yonucu et al. PLoS Computational Biology
- CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ
- (2017) Frederick Allen et al. OncoImmunology
- Anti-leukemic activity of bortezomib and carfilzomib on B-cell precursor ALL cell lines
- (2017) Kazuya Takahashi et al. PLoS One
- Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting
- (2016) Francesca Chiarini et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Tumor microenvironment and cancer therapy resistance
- (2016) Yu Sun CANCER LETTERS
- The role of bortezomib in the treatment of acute lymphoblastic leukemia
- (2016) Mohammad Faizan Zahid Future Oncology
- Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
- (2016) Alice Melão et al. HAEMATOLOGICA
- Microenvironmental cues for T-cell acute lymphoblastic leukemia development
- (2016) Diana Passaro et al. IMMUNOLOGICAL REVIEWS
- Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway
- (2016) Annalisa Lonetti et al. Journal of Hematology & Oncology
- The expression and function of E3 ligase SIAH2 in acute T lymphoblastic leukemia
- (2016) Hongxia Chen et al. LEUKEMIA RESEARCH
- Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis
- (2016) Franziska Scheibe et al. NEUROLOGY
- Nelarabine in the treatment of pediatric and adult patients with T-cell acute lymphoblastic leukemia and lymphoma
- (2016) Tapan M. Kadia et al. Expert Review of Hematology
- Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse
- (2016) Yusuke Higuchi et al. Cancer Genetics
- Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity
- (2016) Alice Melão et al. HAEMATOLOGICA
- AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
- (2015) D. Moradi Manesh et al. BLOOD
- Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
- (2015) Vincenzo Giambra et al. BLOOD
- CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance
- (2015) Lauren A. Pitt et al. CANCER CELL
- CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target
- (2015) Aparecida de Lourdes Perim et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Integrated methylome and transcriptome analysis reveals novel regulatory elements in pediatric acute lymphoblastic leukemia
- (2015) Md Almamun et al. Epigenetics
- Molecular effects of the phosphatidylinositol-3-kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia
- (2015) João Kleber Novais Pereira et al. EUROPEAN JOURNAL OF CANCER
- Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia
- (2015) M T Witkowski et al. LEUKEMIA
- A phase I study of carfilzomib for relapsed or refractory acute myeloid and acute lymphoblastic leukemia
- (2015) Lukas D. Wartman et al. LEUKEMIA & LYMPHOMA
- The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells
- (2015) Carolina Simioni et al. Oncotarget
- Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia
- (2015) Alice Cani et al. Oncotarget
- Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect
- (2015) Nicolas Andre et al. Oncotarget
- Role of tumour angiogenesis in haematological malignancies
- (2015) M Medinger et al. SWISS MEDICAL WEEKLY
- Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation
- (2015) Carolina Simioni et al. Oncotarget
- Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways
- (2014) Dalila Naci et al. CELLULAR SIGNALLING
- The Role of Hypoxia and Exploitation of the Hypoxic Environment in Hematologic Malignancies
- (2014) Barbara Muz et al. MOLECULAR CANCER RESEARCH
- CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment
- (2014) Roberto Würth et al. Frontiers in Cellular Neuroscience
- Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells
- (2013) Jie Zou et al. Journal of Hematology & Oncology
- Targeting the PI3K/Akt/mTOR signaling pathway in B-precursor acute lymphoblastic leukemia and its therapeutic potential
- (2013) L M Neri et al. LEUKEMIA
- Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment
- (2012) Olga Frolova et al. CANCER BIOLOGY & THERAPY
- Microenvironment-mediated resistance to anticancer therapies
- (2012) Oakley C Olson et al. CELL RESEARCH
- Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
- (2012) M. Shibuya JOURNAL OF BIOCHEMISTRY
- Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia
- (2012) C Simioni et al. LEUKEMIA
- Endothelial and perivascular cells maintain haematopoietic stem cells
- (2012) Lei Ding et al. NATURE
- Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells
- (2011) A. H. Nwabo Kamdje et al. BLOOD
- Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia
- (2011) Sergej Konoplev et al. CANCER
- Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer
- (2011) L. Martinet et al. CANCER RESEARCH
- Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
- (2011) Yin Wang et al. Cell Stem Cell
- Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells
- (2011) A Dar et al. LEUKEMIA
- Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104
- (2011) Juliana Benito et al. PLoS One
- Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
- (2010) Kai Kessenbrock et al. CELL
- CXCR7: a new SDF-1-binding receptor in contrast to normal CD34+ progenitors is functional and is expressed at higher level in human malignant hematopoietic cells
- (2010) Maciej Tarnowski et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- The cancer stem cell paradigm: a new understanding of tumor development and treatment
- (2010) Johnathan D Ebben et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Hypoxia-inducible factor-1α protein expression is associated with poor survival in normal karyotype adult acute myeloid leukemia
- (2010) George Deeb et al. LEUKEMIA RESEARCH
- Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
- (2010) Simón Méndez-Ferrer et al. NATURE
- Increased CCL2 and IL-8 in the bone marrow microenvironment in acute lymphoblastic leukemia
- (2010) Jaíra Ferreira de Vasconcellos et al. PEDIATRIC BLOOD & CANCER
- Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926
- (2010) Tara L. Lin et al. PLoS One
- The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology
- (2010) Alberto M. Martelli et al. Cancers
- Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
- (2009) A. K. Ghosh et al. BLOOD
- Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
- (2009) Gregg L. Semenza PHYSIOLOGY
- Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF- B and JNK/AP-1 pathways
- (2008) M. T. Scupoli et al. HAEMATOLOGICA
- Stem Cell Niche: Microenvironment and Beyond
- (2008) Jiwang Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More