Chaperonin-Containing TCP1 Complex (CCT) Promotes Breast Cancer Growth Through Correlations With Key Cell Cycle Regulators

PI3K inhibitors curtail MYC-dependent mutant p53 gain-of-function in head and neck squamous cell carcinoma

(2020) Federica Ganci et al.   CLINICAL CANCER RESEARCH

Investigating Chaperonin-Containing TCP-1 subunit 2 as an essential component of the chaperonin complex for tumorigenesis

(2020) Anne E. Showalter et al.   Scientific Reports

The application and prospect of CDK4/6 inhibitors in malignant solid tumors

(2020) Qi Du et al.   Journal of Hematology & Oncology

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

Suppression of CCT3 inhibits the proliferation and migration in breast cancer cells

(2020) Gang Xu et al.   Cancer Cell International

A review of retroperitoneal liposarcoma genomics

(2020) Robert Tyler et al.   CANCER TREATMENT REVIEWS

Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model

(2020) Zhaoming Huang et al.   OncoTargets and Therapy

Upregulation of CCT-3 Induces Breast Cancer Cell Proliferation Through miR-223 Competition and Wnt/β-Catenin Signaling Pathway Activation

(2020) Hongbo Qu et al.   Frontiers in Oncology

Mechanisms of CDK4/6 Inhibitor Resistance in Luminal Breast Cancer

(2020) Zhen Li et al.   Frontiers in Pharmacology

MYC Oncogene Contributions to Release of Cell Cycle Brakes

(2019) Lucía García-Gutiérrez et al.   Genes

Comprehensive in vivo identification of the c-Myc mRNA interactome using HyPR-MS

(2019) Michele Spiniello et al.   RNA

Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis

(2019) Quanxi Wang et al.   VETERINARY MICROBIOLOGY

CDK4/6 inhibitor treatment for patients with hormone receptor-positive, HER2-negative, advanced or metastatic breast cancer: a US Food and Drug Administration pooled analysis

(2019) Jennifer J Gao et al.   LANCET ONCOLOGY

The substrate specificity of eukaryotic cytosolic chaperonin CCT

(2018) Keith R. Willison   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology

(2018) Josefine Vallin et al.   CELL STRESS & CHAPERONES

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity

(2018) I. Smyrek et al.   Biology Open

Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer

(2017) Ana C. Carr et al.   Oncotarget

PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer

(2017) Orielyz Flores et al.   Theranostics

Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide

(2016) R. Bassiouni et al.   CLINICAL CANCER RESEARCH

The interactome of CCT complex – A computational analysis

(2016) Aswathy Narayanan et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT–mTOR–S6K signaling and drug responses

(2016) Angelika Riedl et al.   JOURNAL OF CELL SCIENCE

Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM

(2016) Yunxiang Zang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer

(2016) MARIANNE SCHMIDT et al.   ONCOLOGY REPORTS

Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM

(2016) Yunxiang Zang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes

(2015) Stephen T. Guest et al.   EXPERIMENTAL CELL RESEARCH

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

β-catenin deacetylation is essential for WNT-induced proliferation of breast cancer cells

(2014) SHAO-HUA WANG et al.   Molecular Medicine Reports

The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption

(2014) M W Lee et al.   Cell Death & Disease

Reversal of Anchorage-Independent Multicellular Spheroid into a Monolayer Mimics a Metastatic Model

(2014) Rani Kunjithapatham et al.   Scientific Reports

Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin

(2014) Moses Kasembeli et al.   PLOS BIOLOGY

Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

(2013) Birdal Bilir et al.   Journal of Translational Medicine

Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

(2013) Antonio Garcia Trinidad et al.   MOLECULAR CELL

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer

(2012) Kenny Chitcholtan et al.   EXPERIMENTAL CELL RESEARCH

Rational Development of a Cytotoxic Peptide To Trigger Cell Death

(2012) Rebecca J. Boohaker et al.   MOLECULAR PHARMACEUTICS

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

(2010) N. Turner et al.   CANCER RESEARCH

Intracellular  -Tubulin/Chaperonin Containing TCP1-  Complex Serves as a Novel Chemotherapeutic Target against Drug-Resistant Tumors

(2009) Y.-F. Lin et al.   CANCER RESEARCH

On the role of the chaperonin CCT in the just-in-time assembly process of APC/CCdc20

(2009) Carien Dekker   FEBS LETTERS

MYC in breast tumor progression

(2008) Yinghua Chen et al.   Expert Review of Anticancer Therapy

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY