Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model

Anticancer and antimetastatic activity of copper(II)-tropolone complex against human breast cancer cells, breast multicellular spheroids and mammospheres

(2019) Lucia M. Balsa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

3D breast cancer microtissue reveals the role of tumor microenvironment on the transport and efficacy of free-doxorubicin in vitro

(2018) Virginia Brancato et al.   Acta Biomaterialia

Involvement of partial EMT in cancer progression

(2018) Masao Saitoh   JOURNAL OF BIOCHEMISTRY

Everolimus inhibits breast cancer cell growth through PI3K/AKT/mTOR signaling pathway

(2018) Liyan Du et al.   Molecular Medicine Reports

Multicellular spheroid based on a triple co-culture: A novel 3D model to mimic pancreatic tumor complexity

(2018) Gianpiero Lazzari et al.   Acta Biomaterialia

Establishment of 2D cell cultures derived from 3D MCF-7 spheroids displaying a Doxorubicin resistant profile

(2018) Ana S. Nunes et al.   Biotechnology Journal

The Different Routes to Metastasis via Hypoxia-Regulated Programs

(2018) Ana Rita Nobre et al.   TRENDS IN CELL BIOLOGY

LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis

(2018) Patricia Masso-Welch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

New horizons in hypoxia signaling pathways

(2017) Christopher W. Pugh et al.   EXPERIMENTAL CELL RESEARCH

Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture

(2017) Cristina E. Rodríguez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Advances in multicellular spheroids formation

(2017) X. Cui et al.   Journal of the Royal Society Interface

Phenotypic and microRNA transcriptomic profiling of the MDA-MB-231 spheroid-enriched CSCs with comparison of MCF-7 microRNA profiling dataset

(2017) Lily Boo et al.   PeerJ

Three-dimensional perfused tumour spheroid model for anti-cancer drug screening

(2016) Xiao Wan et al.   BIOTECHNOLOGY LETTERS

Hypoxia: A Double-Edged Sword in Cancer Therapy

(2016) Hamed Manoochehri Khoshinani et al.   CANCER INVESTIGATION

Generation of Multicellular Breast Cancer Tumor Spheroids: Comparison of Different Protocols

(2016) Karolin Froehlich et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

(2016) Sritama Nath et al.   PHARMACOLOGY & THERAPEUTICS

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation

(2015) Manjulata Singh et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Comparison of 2D- and 3D-culture models as drug-testing platforms in breast cancer

(2015) YOSHINORI IMAMURA et al.   ONCOLOGY REPORTS

Spheroid-plug model as a tool to study tumor development, angiogenesis, and heterogeneity in vivo

(2015) Krzysztof Szade et al.   TUMOR BIOLOGY

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

Three-dimensional in vitro cancer models: a short review

(2014) Chengyang Wang et al.   Biofabrication

Generation of multicellular tumor spheroids of breast cancer cells: How to go three-dimensional

(2013) Anika Nagelkerke et al.   ANALYTICAL BIOCHEMISTRY

Miniaturized Three-Dimensional Cancer Model for Drug Evaluation

(2013) Carrie J. Lovitt et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells

(2013) Julia Dahlmann et al.   BIOMATERIALS

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology

Preclinical development of molecular-targeted agents for cancer

(2010) Alberto Ocana et al.   Nature Reviews Clinical Oncology

Anticancer drug development: the grand challenges

(2010) William N. Hait   NATURE REVIEWS DRUG DISCOVERY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles

(2009) Muri Han et al.   MOLECULAR THERAPY

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

Three-dimensional growth as multicellular spheroid activates the proangiogenic phenotype of colorectal carcinoma cells via LFA-1-dependent VEGF: implications on hepatic micrometastasis

(2008) María Valcárcel et al.   Journal of Translational Medicine