The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology

Interactions between monomeric CCTδ and p150 Glued : A novel function for CCTδ at the cell periphery distinct from the protein folding activity of the molecular chaperone CCT

(2018) Meriem Echbarthi et al.   EXPERIMENTAL CELL RESEARCH

The substrate specificity of eukaryotic cytosolic chaperonin CCT

(2018) Keith R. Willison   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Suppression of CCT3 inhibits malignant proliferation of human papillary thyroid carcinoma cell

(2018) Xiaohui Shi et al.   Oncology Letters

Role of CCT chaperonin in the disassembly of mitotic checkpoint complexes

(2017) Sharon Kaisari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential allosteric mechanism of ATP hydrolysis by the CCT/TRiC chaperone is revealed through Arrhenius analysis

(2017) Ranit Gruber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the PAK4 interactome reveals PAK4 phosphorylation of N-WASP and promotion of Arp2/3-dependent actin polymerization

(2017) Miao Zhao et al.   Oncotarget

Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells

(2016) Yuanyuan Zhang et al.   CANCER LETTERS

The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro

(2015) Andreas Svanström et al.   CELL STRESS & CHAPERONES

Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes

(2015) Stephen T. Guest et al.   EXPERIMENTAL CELL RESEARCH

Over-Expression Analysis of All Eight Subunits of the Molecular Chaperone CCT in Mammalian Cells Reveals a Novel Function for CCTdelta

(2015) Matthias Spiess et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel function of the monomeric CCTε subunit connects the serum response factor pathway to chaperone-mediated actin folding

(2015) Kerryn L. Elliott et al.   MOLECULAR BIOLOGY OF THE CELL

The Structural Basis of Substrate Recognition by the Eukaryotic Chaperonin TRiC/CCT

(2014) Lukasz A. Joachimiak et al.   CELL

Different subunits belonging to the same protein complex often exhibit discordant expression levels and evolutionary properties

(2014) Or Matalon et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Caenorhabditis elegans chaperonin CCT/TRiC is required for actin and tubulin biogenesis and microvillus formation in intestinal epithelial cells

(2014) Keiko Saegusa et al.   MOLECULAR BIOLOGY OF THE CELL

Modulation of STAT3 Folding and Function by TRiC/CCT Chaperonin

(2014) Moses Kasembeli et al.   PLOS BIOLOGY

Programmed Cell Death Protein 5 Interacts with the Cytosolic Chaperonin Containing Tailless Complex Polypeptide 1 (CCT) to Regulate β-Tubulin Folding

(2013) Christopher M. Tracy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of p53 with the CCT Complex Promotes Protein Folding and Wild-Type p53 Activity

(2013) Antonio Garcia Trinidad et al.   MOLECULAR CELL

Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling

(2012) N. Kalisman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling the cortical actin motor

(2012) Julie Grantham et al.   PROTOPLASMA

The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT

(2012) Alexander Leitner et al.   STRUCTURE

A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle

(2012) Stefanie Reissmann et al.   Cell Reports

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

(2011) Carien Dekker et al.   EMBO JOURNAL

Interactions between the actin filament capping and severing protein gelsolin and the molecular chaperone CCT: evidence for nonclassical substrate interactions

(2010) Karen I. Brackley et al.   CELL STRESS & CHAPERONES

Equivalent Mutations in the Eight Subunits of the Chaperonin CCT Produce Dramatically Different Cellular and Gene Expression Phenotypes

(2010) Maya Amit et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

(2010) Inés G Muñoz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement

(2010) Y. Cong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunits of the chaperonin CCT interact with F-actin and influence cell shape and cytoskeletal assembly

(2009) Karen I. Brackley et al.   EXPERIMENTAL CELL RESEARCH

The actin cytoskeleton in cancer cell motility

(2008) Michael F. Olson et al.   CLINICAL & EXPERIMENTAL METASTASIS

The interaction network of the chaperonin CCT

(2008) Carien Dekker et al.   EMBO JOURNAL

Regulation of Dynactin through the Differential Expression of p150GluedIsoforms

(2008) Ram Dixit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pachygyria-causing α-Tubulin Mutation Results in Inefficient Cycling with CCT and a Deficient Interaction with TBCB

(2008) Guoling Tian et al.   MOLECULAR BIOLOGY OF THE CELL

Defining the TRiC/CCT interactome links chaperonin function to stabilization of newly made proteins with complex topologies

(2008) Alice Y Yam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans

(2007) Victor F. Lundin et al.   DEVELOPMENTAL BIOLOGY