Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro

Fenofibrate inhibits mTOR-p70S6K signaling and simultaneously induces cell death in human prostate cancer cells

(2018) Xin Lian et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model

(2017) Chi Huu Nguyen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MicroRNA-210 induces apoptosis in colorectal cancer via induction of reactive oxygen

(2016) Katrin E. Tagscherer et al.   Cancer Cell International

MiR-20b Displays Tumor-Suppressor Functions in Papillary Thyroid Carcinoma by Regulating the MAPK/ERK Signaling Pathway

(2016) Shubin Hong et al.   THYROID

Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

(2016) Huaping Liu et al.   Oncotarget

miR-497-5p inhibits cell proliferation and invasion by targeting KCa3.1 in angiosarcoma

(2016) Yaobing Chen et al.   Oncotarget

PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth

(2015) Omran Abu Aboud et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Contribution of Angiogenesis to the Process of Metastasis

(2015) Diane R. Bielenberg et al.   CANCER JOURNAL

Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway

(2015) Rajmohan Murali et al.   Oncotarget

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells

(2015) Dongfeng Han et al.   Oncotarget

Efficacy of Tie2 Receptor Antagonism in Angiosarcoma

(2015) Jason R. Hasenstein et al.   NEOPLASIA

Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

(2014) Jia Liu et al.   Asian Pacific Journal of Cancer Prevention

Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway

(2014) Ting Li et al.   BMC CANCER

MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer

(2014) Nicola Valeri et al.   CANCER CELL

Molecular Mechanisms of Fenofibrate-Induced Metabolic Catastrophe and Glioblastoma Cell Death

(2014) Anna Wilk et al.   MOLECULAR AND CELLULAR BIOLOGY

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

(2014) Sam Behjati et al.   NATURE GENETICS

MicroRNAs in Soft Tissue Sarcomas: Overview of the Accumulating Evidence and Importance as Novel Biomarkers

(2014) Tomohiro Fujiwara et al.   Biomed Research International

Fenofibrate down-regulates the expressions of androgen receptor (AR) and AR target genes and induces oxidative stress in the prostate cancer cell line LNCaP

(2013) Hu Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PPARα agonist fenofibrate suppresses B-cell lymphoma in mice by modulating lipid metabolism

(2013) Jianfeng Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

(2013) J. Ferlay et al.   EUROPEAN JOURNAL OF CANCER

Pathogenesis of human hemangiosarcomas and hemangiomas

(2013) Liping Liu et al.   HUMAN PATHOLOGY

MicroRNA-31 Sensitizes Human Breast Cells to Apoptosis by Direct Targeting of Protein Kinase C ϵ (PKCϵ)

(2013) Cindy Körner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive prognostic impact of miR-210 in non-small cell lung cancer

(2013) Marte Eilertsen et al.   LUNG CANCER

Pharmacologic Inhibition of MEK Signaling Prevents Growth of Canine Hemangiosarcoma

(2013) N. J. Andersen et al.   MOLECULAR CANCER THERAPEUTICS

miR-203 regulates the proliferation, apoptosis and cell cycle progression of pancreatic cancer cells by targeting Survivin

(2013) DONG XU et al.   Molecular Medicine Reports

A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer

(2013) Nathan J. Robison et al.   PEDIATRIC BLOOD & CANCER

miR-29 targets Akt3 to reduce proliferation and facilitate differentiation of myoblasts in skeletal muscle development

(2013) W Wei et al.   Cell Death & Disease

The MicroRNA-17-92 Family of MicroRNA Clusters in Development and Disease

(2012) Carla P. Concepcion et al.   CANCER JOURNAL

Fibrates are an essential part of modern anti-dyslipidemic arsenal: spotlight on atherogenic dyslipidemia and residual risk reduction

(2012) Alexander Tenenbaum et al.   Cardiovascular Diabetology

Therapeutic Effects of PPARα Agonists on Diabetic Retinopathy in Type 1 Diabetes Models

(2012) Ying Chen et al.   DIABETES

The Link between the Metabolic Syndrome and Cancer

(2012) Sandra Braun et al.   International Journal of Biological Sciences

Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells

(2012) Jundong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Expression Profiles of Hematopoietic Stem Cell, Endothelial Cell, and Myeloid Cell Antigens in Spontaneous and Chemically Induced Hemangiosarcomas and Hemangiomas in Mice

(2012) Satoko Kakiuchi-Kiyota et al.   TOXICOLOGIC PATHOLOGY

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect

(2012) Renée F. Johnson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bezafibrate enhances proliferation and differentiation of osteoblastic MC3T3-E1 cells via AMPK and eNOS activation

(2011) Xing Zhong et al.   ACTA PHARMACOLOGICA SINICA

Metastatic angiosarcomas: doxorubicin-based regimens, weekly paclitaxel and metastasectomy significantly improve the outcome

(2011) N. Penel et al.   ANNALS OF ONCOLOGY

Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas

(2011) Antoine Italiano et al.   CANCER

Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1β by suppressing AMP-activated protein kinase (AMPK) activation

(2011) M. Villarroel et al.   DIABETOLOGIA

Peroxisome Proliferator-Activated Receptors Modulate Proliferation and Angiogenesis in Human Endometrial Carcinoma

(2011) M. Nickkho-Amiry et al.   MOLECULAR CANCER RESEARCH

Cardiovascular toxicity of anti-angiogenic drugs

(2011) Gaetan des Guetz et al.   Targeted Oncology

Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007

(2010) Jorge Albores-Saavedra et al.   Annals of Diagnostic Pathology

miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells

(2010) M Tomé et al.   CELL DEATH AND DIFFERENTIATION

miR-20b modulates VEGF expression by targeting HIF-1α and STAT3 in MCF-7 breast cancer cells

(2010) Sandra Cascio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

S-MED: Sarcoma microRNA Expression Database

(2010) Aaron L Sarver et al.   LABORATORY INVESTIGATION

Fenofibrate suppresses microvascular inflammation and apoptosis through adenosine monophosphate–activated protein kinase activation

(2010) Atsuko Tomizawa et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Fenofibrate but not fenofibric acid inhibits 11beta-hydroxysteroid dehydrogenase 1 in C2C12 myotubes

(2010) Chi Hyun Kim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fenofibric Acid

(2009) Lily P.H. Yang et al.   American Journal of Cardiovascular Drugs

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

(2009) Johanna Manner et al.   AMERICAN JOURNAL OF PATHOLOGY

PPAR  agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition

(2008) D. Panigrahy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA