Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity

TRIM-NHL as RNA binding Ubiquitin E3 Ligase (RBUL): Implication in development and disease pathogenesis

(2021) Shanikumar Goyani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting TRIM Proteins: A quest towards drugging an emerging protein class

(2021) Francesca D’Amico et al.   CHEMBIOCHEM

TRIM Proteins in Colorectal Cancer: TRIM8 as a Promising Therapeutic Target in Chemo Resistance

(2021) Flaviana Marzano et al.   Biomedicines

New approaches to target RNA binding proteins

(2021) Ashley R. Julio et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

TRIM66 promotes malignant progression of prostate carcinoma through the JAK/STAT pathway

(2020) Hongwen Cao et al.   FEBS Open Bio

TIF1 Proteins in Genome Stability and Cancer

(2020) Roisin M. McAvera et al.   Cancers

Targeted modulation of E3 ligases using engineered ubiquitin variants

(2020) Nicole LeBlanc et al.   FEBS Journal

Rise of TRIM8: A Molecule of Duality

(2020) Utsa Bhaduri et al.   Molecular Therapy-Nucleic Acids

First targeted protein degrader hits the clinic

(2019) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

(2019) Felix Preston Williams et al.   BIOLOGICAL CHEMISTRY

The role of TRIM family proteins in the regulation of cancer stem cell self-renewal: Concise review

(2019) Anna Maria Jaworska et al.   STEM CELLS

A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification

(2018) Sarah Nicklas et al.   CELL DEATH AND DIFFERENTIATION

Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

(2018) Lara N. Gechijian et al.   Nature Chemical Biology

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders

(2018) Arlene J. George et al.   Frontiers in Genetics

Acute and rapid degradation of endogenous proteins by Trim-Away

(2018) Dean Clift et al.   Nature Protocols

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

(2018) Ka-wing Fong et al.   Nature Communications

TRIM proteins and diseases

(2017) Masashi Watanabe et al.   JOURNAL OF BIOCHEMISTRY

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3

(2017) Changming Zhang et al.   Molecular Oncology

Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase

(2017) Daria M. Dawidziak et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

TRIM Family Proteins: Roles in Autophagy, Immunity, and Carcinogenesis

(2017) Shigetsugu Hatakeyama   TRENDS IN BIOCHEMICAL SCIENCES

Promyelocytic Leukemia Protein Is an Essential Regulator of Stem Cell Pluripotency and Somatic Cell Reprogramming

(2017) Christiana Hadjimichael et al.   Stem Cell Reports

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling

(2016) Jinlong Yin et al.   Oncotarget

TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development

(2016) Patrycja Czerwińska et al.   Oncotarget

Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

(2016) Jacint G. Sanchez et al.   Cell Reports

Targeting ubiquitination for cancer therapies

(2015) John Kenneth Morrow et al.   Future Medicinal Chemistry

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

(2015) James Bennett et al.   JOURNAL OF MEDICINAL CHEMISTRY

TRIM-NHL proteins in development and disease

(2015) Cristina Tocchini et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Human Brat Ortholog TRIM3 Is a Tumor Suppressor That Regulates Asymmetric Cell Division in Glioblastoma

(2014) G. Chen et al.   CANCER RESEARCH

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

(2014) Ju Liu et al.   CELL DEATH AND DIFFERENTIATION

A Map of General and Specialized Chromatin Readers in Mouse Tissues Generated by Label-free Interaction Proteomics

(2012) H. Christian Eberl et al.   MOLECULAR CELL

The PHD finger: a versatile epigenome reader

(2011) Roberto Sanchez et al.   TRENDS IN BIOCHEMICAL SCIENCES

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

(2010) F. Okumura et al.   JOURNAL OF CELL SCIENCE

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

TRIM-NHL Proteins Take on miRNA Regulation

(2009) Inga Loedige et al.   CELL

Activating the ubiquitin family: UBA6 challenges the field

(2008) Marcus Groettrup et al.   TRENDS IN BIOCHEMICAL SCIENCES