Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer’s Disease

Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis

(2021) Pradeep K. Shukla et al.   Scientific Reports

Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain

(2021) Jingjing Rao et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer’s disease

(2020) Zhuo Li et al.   JOURNAL OF NEUROCHEMISTRY

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

(2020) Carolina Pellegrini et al.   PROGRESS IN NEUROBIOLOGY

Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease

(2020) Yijing Chen et al.   Biomed Research International

NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson’s disease

(2020) Hayate Javed et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

27-Hydroxycholesterol contributes to cognitive deficits in APP/PS1 transgenic mice through microbiota dysbiosis and intestinal barrier dysfunction

(2020) Ying Wang et al.   Journal of Neuroinflammation

New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

(2020) Heping Shen et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study

(2020) Vanessa Stadlbauer et al.   BMC Geriatrics

Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model

(2020) Chun Chen et al.   Science Advances

The gut microbiota attenuate neuroinflammation in manganese exposure by inhibiting cerebral NLRP3 inflammasome

(2020) Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

DNA Double-Strand Break Accumulation in Alzheimer’s Disease: Evidence from Experimental Models and Postmortem Human Brains

(2020) Nidheesh Thadathil et al.   MOLECULAR NEUROBIOLOGY

Prevention and mitigation of alcohol-induced neuroinflammation by Lactobacillus plantarum by an EGF receptor-dependent mechanism

(2020) Pradeep K. Shukla et al.   NUTRITIONAL NEUROSCIENCE

Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease

(2020) Tiberiu Loredan Stan et al.   Scientific Reports

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease

(2020) Feng Zhang et al.   ACTA PHARMACOLOGICA SINICA

The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology

(2020) Andrina Rutsch et al.   Frontiers in Immunology

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

(2019) Qianquan Ma et al.   Journal of Neuroinflammation

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Systemic inflammation impairs microglial Aβ clearance through NLRP 3 inflammasome

(2019) Dario Tejera et al.   EMBO JOURNAL

Gut Microbiota Alteration and Its Time Course in a Tauopathy Mouse Model

(2019) Bin-Lu Sun et al.   JOURNAL OF ALZHEIMERS DISEASE

Probiotics modulate the microbiota–gut–brain axis and improve memory deficits in aged SAMP8 mice

(2019) Xueqin Yang et al.   Acta Pharmaceutica Sinica B

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Gnal haploinsufficiency causes genomic instability and increased sensitivity to haloperidol

(2019) Mohammad Moshahid Khan et al.   EXPERIMENTAL NEUROLOGY

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

(2019) Min-Soo Kim et al.   GUT

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice

(2019) Gunjan D. Manocha et al.   NEUROBIOLOGY OF AGING

Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2

(2019) Yuan Zhang et al.   Microbiome

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

(2019) Hae-Ji Lee et al.   Scientific Reports

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

Lactobacillus plantarum prevents and mitigates alcohol-induced disruption of colonic epithelial tight junctions, endotoxemia, and liver damage by an EGF receptor–dependent mechanism

(2018) Pradeep K. Shukla et al.   FASEB JOURNAL

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan

(2018) C. Bäuerl et al.   LETTERS IN APPLIED MICROBIOLOGY

Dementia: Peripheral inflammation could be a prodromal indicator of dementia

(2018) Heather Wood   Nature Reviews Neurology

DNA damage and neurodegenerative phenotypes in aged Ciz1 null mice

(2018) Mohammad Moshahid Khan et al.   NEUROBIOLOGY OF AGING

Microbiota Signaling Pathways that Influence Neurologic Disease

(2018) Laura M. Cox et al.   Neurotherapeutics

Alzheimer’s disease hypothesis and related therapies

(2018) Xiaoguang Du et al.   Translational Neurodegeneration

Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression

(2018) Sandra Semar et al.   JOURNAL OF ALZHEIMERS DISEASE

Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches

(2018) Mir Hilal Ahmad et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression

(2018) Patrick P. Lowe et al.   Journal of Neuroinflammation

Intestinal barrier dysfunction orchestrates the onset of inflammatory host–microbiome cross-talk in a human gut inflammation-on-a-chip

(2018) Woojung Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Defensin-5 Blocks Ethanol and Colitis-Induced Dysbiosis, Tight Junction Disruption and Inflammation in Mouse Intestine

(2018) Pradeep K. Shukla et al.   Scientific Reports

Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals

(2018) Bonggi Lee et al.   Journal of Immunology Research

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

(2017) Ling Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Neurotransmitters: The Critical Modulators Regulating Gut-Brain Axis

(2017) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

(2017) Leslie Freeman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila

(2017) Shih-Cheng Wu et al.   Nature Communications

The intestinal barrier: a fundamental role in health and disease

(2017) Maaike Vancamelbeke et al.   Expert Review of Gastroenterology & Hepatology

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer’s disease

(2016) Marina Saresella et al.   Molecular Neurodegeneration

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

(2016) G B Rogers et al.   MOLECULAR PSYCHIATRY

Activation of Bacteroides fragilis toxin by a novel bacterial protease contributes to anaerobic sepsis in mice

(2016) Vivian M Choi et al.   NATURE MEDICINE

Impact of the gut microbiota on inflammation, obesity, and metabolic disease

(2016) Claire L. Boulangé et al.   Genome Medicine

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Gut/brain axis and the microbiota

(2015) Emeran A. Mayer et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

(2015) Thomas Clairembault et al.   Acta Neuropathologica Communications

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

Systemic inflammation regulates microglial responses to tissue damagein vivo

(2014) Stefka Gyoneva et al.   GLIA

Inflammasome-Microbiota Interplay in Host Physiologies

(2013) Janelle S. Ayres   Cell Host & Microbe

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components

(2011) Dulantha Ulluwishewa et al.   JOURNAL OF NUTRITION

Normal gut microbiota modulates brain development and behavior

(2011) R. D. Heijtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

(2010) Simon A. Hirota et al.   INFLAMMATORY BOWEL DISEASES

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

(2008) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY