Metformin Attenuates Monosodium-Iodoacetate-Induced Osteoarthritis via Regulation of Pain Mediators and the Autophagy–Lysosomal Pathway

Metformin limits osteoarthritis development and progression through activation of AMPK signalling

(2020) Jun Li et al.   ANNALS OF THE RHEUMATIC DISEASES

Circulating microRNA let‑7e is decreased in knee osteoarthritis, accompanied by elevated apoptosis and reduced autophagy

(2020) Lei Feng et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Metformin Mitigates Cartilage Degradation by Activating AMPK/SIRT1-Mediated Autophagy in a Mouse Osteoarthritis Model

(2020) Chenzhong Wang et al.   Frontiers in Pharmacology

Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis

(2019) Min-Jung Park et al.   JOURNAL OF IMMUNOLOGY

Combination COX-2 inhibitor and metformin attenuate rate of joint replacement in osteoarthritis with diabetes: A nationwide, retrospective, matched-cohort study in Taiwan

(2018) Chieh-Hua Lu et al.   PLoS One

Metformin and Autoimmunity: A “New Deal” of an Old Drug

(2018) Francesco Ursini et al.   Frontiers in Immunology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1/Parkin-dependent mitophagy in primary chondrocytes

(2018) Chenzhong Wang et al.   BioScience Trends

T Cells in Osteoarthritis: Alterations and Beyond

(2017) Yu-sheng Li et al.   Frontiers in Immunology

Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis

(2016) Augustin Latourte et al.   ANNALS OF THE RHEUMATIC DISEASES

Downregulation of IL-10 secretion by Treg cells in osteoarthritis is associated with a reduction in Tim-3 expression

(2016) Shufeng Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis

(2016) Mark D. Kohn et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

TRPV1 Pain Receptors Regulate Longevity and Metabolism by Neuropeptide Signaling

(2014) Céline E. Riera et al.   CELL

TRPV1, CGRP and SP in scalp arteries of patients suffering from chronic migraine

(2014) Marina Del Fiacco et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis

(2014) Hye-Jin Son et al.   MEDIATORS OF INFLAMMATION

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

The hallmarks of osteoarthritis and the potential to develop personalised disease-modifying pharmacological therapeutics

(2014) D.P. Tonge et al.   OSTEOARTHRITIS AND CARTILAGE

CD4+CD25+/highCD127low/- regulatory T cells are enriched in rheumatoid arthritis and osteoarthritis joints—analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood

(2014) Babak Moradi et al.   ARTHRITIS RESEARCH & THERAPY

Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro

(2014) FANG-JIE ZHANG et al.   Experimental and Therapeutic Medicine

Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis

(2013) Su-Jin Moon et al.   ARCHIVES OF PHARMACAL RESEARCH

The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial

(2013) L. Gallelli et al.   OSTEOARTHRITIS AND CARTILAGE

The Roles of Catabolic Factors in the Development of Osteoarthritis

(2013) Dominick J. Blasioli et al.   TISSUE ENGINEERING PART B-REVIEWS

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis

(2011) Manon C Zweers et al.   ARTHRITIS RESEARCH & THERAPY

Anabolic/Catabolic Balance in Pathogenesis of Osteoarthritis: Identifying Molecular Targets

(2011) Michael B. Mueller et al.   PM&R

Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats

(2010) Frank Richter et al.   ARTHRITIS AND RHEUMATISM

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Antinociceptive effects of tumor necrosis factor α neutralization in a rat model of antigen-induced arthritis: Evidence of a neuronal target

(2008) Michael K. Boettger et al.   ARTHRITIS AND RHEUMATISM

Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint®) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial

(2008) Douglas S Kalman et al.   Nutrition Journal