Article
Biochemistry & Molecular Biology
George Notas, Athanasios Panagiotopoulos, Rodanthi Vamvoukaki, Konstantina Kalyvianaki, Foteini Kiagiadaki, Alexandra Deli, Marilena Kampa, Elias Castanas
Summary: ER alpha 36 collaborates with GPER1 to inhibit NF kappa B-mediated inflammation and ER alpha 66 actions in breast cancer cells. Particularly, this effect is more significant in the absence of ER alpha 66. Moreover, overexpression of ER alpha 36 enhances the inhibitory effect of estrogen on inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lin Xie, Ye Cheng, Wen Du, Lili Fu, Zhaonan Wei, Yuting Guan, Yi Wang, Changlin Mei, Chuanming Hao, Min Chen, Xiangchen Gu
Summary: This study demonstrates the role of GPER1 in macrophage-mediated renal fibrosis by inhibiting M1 and M2 macrophage activation, providing a promising therapeutic target for treating renal fibrosis.
CELL DEATH & DISEASE
(2023)
Article
Neurosciences
Andree-Anne Poirier, Melanie Cote, Melanie Bourque, Hend Jarras, Jerome Lamontagne-Proulx, Marc Morissette, Therese Di Paolo, Denis Soulet
Summary: Estrogens have beneficial effects in Parkinson's disease, mainly through activation of the GPER1 receptor. Targeting GPER1 could be a promising approach for future estrogen-based hormone therapies in early PD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Oncology
Zhenhua Li, Yaqiang Pan, Qinghua Liu, Jian Wang, Chang Liu, Laihao Qu, Dingbiao Li
Summary: The expression of GPER1 is associated with ER and EGFR mutations in lung adenocarcinoma. GPER1 regulates ER expression and MAPK signaling, and co-inhibition of GPER1 and ER can decrease phosphorylation of ERK1/2 and Akt in cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Johanna Loris, Lena Hanesch, Gerd Bauerschmitz, Julia Gallwas, Carsten Gruendker
Summary: GPER1 appears to have a tumor-suppressive effect in vulvar carcinoma, and its tumorigenic potential can be reduced by activation with agonist G1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
V Duran-Laforet, C. Pena-Martinez, A. Garcia-Culebras, L. Alzamora, M. A. Moro, I Lizasoain
Summary: The immune response plays a crucial role in ischemic stroke, mainly by activating circulating immune cells to induce an inflammatory response. Antagonists targeting TLR4 have the potential to serve as pharmacological tools for stroke treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
George Maiti, Jihane Frikeche, Carly Yuen-Man Lam, Asim Biswas, Vishal Shinde, Marie Samanovic, Jonathan C. Kagan, Mark J. Mulligan, Shukti Chakravarti
Summary: The ECM protein lumican plays a significant role in regulating infections and inflammation, promoting TLR4 response while restricting TLR9 in immune cells. Lumican may be internalized by immune cells to modulate their transcriptional programs and effector responses, suggesting potential therapeutic applications in future treatments.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Jingshi Liu, Yongdong Niu, Bin Zhang, Qisi Sun, Haiyi Li, Lu Bai, Zhongjing Su
Summary: The expression levels of GPER1 are found to be associated with tumor type and survival rates in esophageal carcinoma. In overall esophageal carcinoma, low expression of GPER1 is correlated with poor survival rates, while overexpression of GPER1 is associated with the development of esophageal adenocarcinoma and its pre-cancerous lesion. Furthermore, the protein expression of GPER1 is higher in esophageal adenocarcinoma tissues compared to normal esophageal tissues, whereas it is lower in esophageal squamous cell carcinoma tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Eva Pastille, Tabea Fassnacht, Alexandra Adamczyk, Nhi Ngo Thi Phuong, Jan Buer, Astrid M. Westendorf
Summary: In this study, the research team found that blocking TLR4 signaling during the inflammatory phases of CAC can significantly reduce the development and progression of colonic tumors, as well as decrease inflammation levels, providing a novel approach to impede CAC development.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Bahareh Kashani, Zahra Zandi, Atieh Pourbagheri-Sigaroodi, Davood Bashash, Seyed H. Ghaffari
Summary: The TLR family is crucial for pattern recognition in innate immunity, with TLR4 playing a significant role in inflammatory diseases and cancer. Aberrant expression of TLR4 in tumors is closely associated with tumorigenesis, progression, and drug resistance. TLR4 inhibitors show promise in cancer therapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Prarthana Gopinath, Revathi Paramasivam Oviya, Gopal Gopisetty
Summary: Estrogen plays a significant role in tumorigenesis, but some breast cancer patients develop resistance to estrogen. Non-classical estrogen signaling through various pathways is important in cancer development and clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Ziwei Tang, Qifu Li, Qingfeng Cheng, Mei Mei, Ying Song, Zhipeng Du, Wenwen He, Jinbo Hu, Shumin Yang, Zhihong Wang
Summary: The study demonstrated that GPER1 can partially mediate aldosterone-induced endothelial inflammatory response, which may involve the PI3K pathway signaling. Suppression of MR did not affect the expression of GPER1, while aldosterone induction promoted the expression of MR.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Immunology
Ashti M. Shah, Ruben Zamora, Sebastian Korff, Derek Barclay, Jinling Yin, Fayten El-Dehaibi, Timothy R. Billiar, Yoram Vodovotz
Summary: Trauma/hemorrhagic shock followed by resuscitation leads to inflammation and organ dysfunction, with TLR4 playing a role in binding damage-associated molecular pattern molecules. TLR4-null mice showed more localized expression of inflammatory mediators compared to wild type mice. IL-17A showed positive correlations with GM-CSF, IL-10, and TNF in the kidney and gut.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Zulqurnain Haider, Amirhossein Sahebkar, Ali H. Eid
Summary: Atherosclerosis is a major cause of cardiovascular disease-related morbidity and mortality, with higher mortality rates in men than women. It has been suggested that estrogen plays a protective role in the cardiovascular system through the membranous G-protein coupled estrogen receptor, GPER1. Activation of GPER1 regulates vascular smooth cell phenotype and reduces LDL levels by promoting LDL receptor expression and facilitating LDL re-uptake in liver cells. Selective activation of GPER1 may be a promising strategy to prevent or suppress atherosclerosis with fewer side effects compared to non-selective estrogen.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Vasiliki Pelekanou, Eleftheria Anastasiou, Efstathia Bakogeorgou, George Notas, Marilena Kampa, Rolando Garcia-Milian, Katerina Lavredaki, Eleni Moustou, Georgia Chinari, Petroula Arapantoni, Anthony O'Grady, Vassilios Georgoulias, Andreas Tsapis, Efstathios N. Stathopoulos, Elias Castanas
Article
Nutrition & Dietetics
Nikolaos Peroulis, Vasilis P. Androutsopoulos, George Notas, Stella Koinaki, Elsa Giakoumaki, Apostolos Spyros, Efstathia Manolopoulou, Sophia Kargaki, Maria Tzardi, Eleni Moustou, Euripides G. Stephanou, Efstathia Bakogeorgou, Niki Malliaraki, Maria Niniraki, Christos Lionis, Elias Castanas, Marilena Kampa
EUROPEAN JOURNAL OF NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Niki Malliaraki, Kleanthi Lakiotaki, Rodanthi Vamvoukaki, George Notas, Ioannis Tsamardinos, Marilena Kampa, Elias Castanas
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Endocrinology & Metabolism
Elias K. Spanakis, Lakshmi G. Singh, Tariq Siddiqui, John D. Sorkin, George Notas, Michelle F. Magee, Jeffrey C. Fink, Min Zhan, Guillermo E. Umpierrez
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Oncology
Marilena Kampa, George Notas, Efstathios N. Stathopoulos, Andreas Tsapis, Elias Castanas
FRONTIERS IN ONCOLOGY
(2020)
Article
Pharmacology & Pharmacy
Athanasios A. Panagiotopoulos, Christina Papachristofi, Konstantina Kalyvianaki, Panagiotis Malamos, Panayiotis A. Theodoropoulos, George Notas, Theodora Calogeropoulou, Elias Castanas, Marilena Kampa
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2020)
Article
Biochemistry & Molecular Biology
Athanasios A. Panagiotopoulos, Chara Polioudaki, Sotirios G. Ntallis, Dimitris Dellis, George Notas, Christos A. Panagiotidis, Panayiotis A. Theodoropoulos, Elias Castanas, Marilena Kampa
Summary: The study identified a novel NLS signal sequence for importin 7 recognition using unsupervised computational methods and experimental validation, showcasing its effectiveness in breast cancer cells. Furthermore, it was found that importin 7-mediated nuclear protein transport is affected by cargo protein phosphorylation.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biochemistry & Molecular Biology
George Notas, Athanasios Panagiotopoulos, Rodanthi Vamvoukaki, Konstantina Kalyvianaki, Foteini Kiagiadaki, Alexandra Deli, Marilena Kampa, Elias Castanas
Summary: ER alpha 36 collaborates with GPER1 to inhibit NF kappa B-mediated inflammation and ER alpha 66 actions in breast cancer cells. Particularly, this effect is more significant in the absence of ER alpha 66. Moreover, overexpression of ER alpha 36 enhances the inhibitory effect of estrogen on inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Athanasios Panagiotopoulos, Melpomeni Tseliou, Ioannis Karakasiliotis, Danai-Maria Kotzampasi, Vangelis Daskalakis, Nikolaos Kesesidis, George Notas, Christos Lionis, Marilena Kampa, Stergios Pirintsos, George Sourvinos, Elias Castanas
Summary: This study suggests that the natural monoterpene p-cymene may act as a potential novel agent for treating COVID-19 and other RNA virus-induced diseases. Molecular simulations and in vitro experiments display that p-cymene can interact with SARS-CoV-2 proteins and inhibit viral replication, with potential similar effects on other RNA viruses, providing a new possibility for broad-spectrum antiviral drugs.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Medicine, General & Internal
Anna Daskalaki, Sofia Xenaki, Konstantinos Lasithiotakis, Alexandros Chrysos, Marilena Kampa, George Notas, Emmanuel Chrysos
Summary: This study aimed to investigate whether early post-surgery PTH and calcium levels can be used for the early identification of patients at risk for symptomatic hypocalcemia. The results showed that 4-hour calcium levels and the 4-h/pre-surgery PTH ratio were good indicators. These findings may have important implications for clinical practice in post-thyroidectomy patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Hematology
George Notas
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Correction
Medicine, General & Internal
Anna Daskalaki, Sofia Xenaki, Konstantinos Lasithiotakis, Alexandros Chrysos, Marilena Kampa, George Notas, Emmanuel Chrysos
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ioannis Tsomidis, George Notas, Costas Xidakis, Argyro Voumvouraki, Dimitrios N. Samonakis, Mairi Koulentaki, Elias Kouroumalis
Summary: This study investigated enzyme activities in liver tissue of patients with liver fibrosis and found that PH significantly increased in early and late stages of PBC, while collagenase only decreased in the late stages. Viral fibrosis is due to decreased degradation rather than increased synthesis. The final biochemical stages of liver fibrosis may vary according to underlying etiology.
Article
Sport Sciences
Nikolaos Androulakis, Nikolaos Koundourakis, Christos Tsiakiris, George Notas
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2020)
