Role of GPER-Mediated Signaling in Testicular Functions and Tumorigenesis

The meaning of non-classical estrogen receptors and peroxisome proliferator-activated receptor for boar Leydig cell of immature testis

(2020) M. Kotula-Balak et al.   ACTA HISTOCHEMICA

Androgen receptor, aromatase, oestrogen receptor α/β and G protein‐coupled receptor 30 expression in the testes and epididymides of adult sheep

(2020) Wenbo Ge et al.   REPRODUCTION IN DOMESTIC ANIMALS

Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa?

(2020) Jana Antalikova et al.   Cells

Towards understanding leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator–activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors?

(2020) M. Kotula-Balak et al.   PROTOPLASMA

Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma

(2020) Christopher A. Natale et al.   Cellular and Molecular Gastroenterology and Hepatology

Do estrogens regulate lipid status in testicular steroidogenic Leydig cell?

(2019) A. Milon et al.   ACTA HISTOCHEMICA

Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation

(2019) Silvina Beatriz Meroni et al.   Frontiers in Endocrinology

On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer

(2019) Tiziano Baroni et al.   Frontiers in Endocrinology

Identification and characterization of telocytes in rat testis

(2019) Yifei Liu et al.   Aging-US

Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo?

(2019) P. Pawlicki et al.   ANIMAL REPRODUCTION SCIENCE

Leydig cell tumorigenesis - implication of G-protein coupled membrane estrogen receptor, peroxisome proliferator-activated receptor and xenoestrogen exposure. In vivo and in vitro appraisal

(2019) E. Gorowska-Wojtowicz et al.   TISSUE & CELL

Bisphenol A-elicited miR-146a-5p impairs murine testicular steroidogenesis through negative regulation of Mta3 signaling

(2018) Guo-zheng Gao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of G-protein-coupled membrane estrogen receptor in mouse Leydig cell function—in vivo and in vitro evaluation

(2018) M. Kotula-Balak et al.   CELL AND TISSUE RESEARCH

MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells

(2018) Xavier Vidal-Gómez et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Crosstalk between nuclear and G protein-coupled estrogen receptors

(2018) Shannon N. Romano et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

G protein-coupled estrogen receptor (GPER) in adult boar testes, epididymis and spermatozoa during epididymal maturation

(2018) Romana Krejčířová et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Activation of G protein-coupled estrogen receptor signaling inhibits melanoma and improves response to immune checkpoint blockade

(2018) Christopher A Natale et al.   eLife

Telocytes in the mouse testicular interstitium: implications of G-protein-coupled estrogen receptor (GPER) and estrogen-related receptor (ERR) in the regulation of mouse testicular interstitial cells

(2018) Piotr Pawlicki et al.   PROTOPLASMA

Telocytes are localized to testis of the bank vole (Myodes glareolus) and are affected by lighting conditions and G-coupled membrane estrogen receptor (GPER) signaling

(2018) Agnieszka Milon et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Distribution and number of Cajal-like cells in testis tissue with azoospermia

(2017) Eray Hasirci et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Testicular cancer from diagnosis to epigenetic factors

(2017) Mariarosaria Boccellino et al.   Oncotarget

Low concentration of BPA induces mice spermatocytes apoptosis via GPR30

(2017) Chaoliang Wang et al.   Oncotarget

Rapid steroid hormone actions via membrane receptors

(2016) Nofrat Schwartz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Implication of the estrogen receptors GPER, ESR1, ESR2 in post-testicular maturations of equine spermatozoa

(2016) Camille Gautier et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Lipid droplets maintain lipid homeostasis during anaphase for efficient cell separation in budding yeast

(2016) Po-Lin Yang et al.   MOLECULAR BIOLOGY OF THE CELL

PI3K/Akt Activated by GPR30 and Src Regulates 17β-Estradiol-Induced Cultured Immature Boar Sertoli Cells Proliferation

(2016) Wei-Rong Yang et al.   Reproductive Sciences

Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors

(2016) Hongyan Qian et al.   Journal of Immunology Research

Guidelines on Testicular Cancer: 2015 Update

(2015) Peter Albers et al.   EUROPEAN UROLOGY

High Levels of Gpr30 Protein in Human Testicular Carcinoma In Situ and Seminomas Correlate with Low Levels of Estrogen Receptor-Beta and Indicate a Switch in Estrogen Responsiveness

(2015) Francesca Boscia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immunolocalization of G protein-coupled estrogen receptor in the rat epididymis

(2015) Griselle B. Martínez-Traverso et al.   Reproductive Biology and Endocrinology

Stallion spermatozoa: Putative target of estrogens; presence of the estrogen receptors ESR1, ESR2 and identification of the estrogen-membrane receptor GPER

(2014) Brahim Arkoun et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Genetic Variants of GPER/GPR30, a Novel Estrogen-Related G Protein Receptor, Are Associated with Human Seminoma

(2014) Nicolas Chevalier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of G protein-coupled estrogen receptor in human and pig spermatozoa

(2014) V. Rago et al.   JOURNAL OF ANATOMY

Activation of GPER-1 Estradiol Receptor Downregulates Production of Testosterone in Isolated Rat Leydig Cells and Adult Human Testis

(2014) Laurent Vaucher et al.   PLoS One

Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells

(2014) Li-Chen Ge et al.   TOXICOLOGY LETTERS

Expression of the oestrogen receptor GPER by testicular peritubular cells is linked to sexual maturation and male fertility

(2014) F. Sandner et al.   Andrology

GPER signaling in spermatogenesis and testicular tumors

(2014) Adele Chimento   Frontiers in Endocrinology

Membrane Estrogen Receptors: Their Role in Blood Pressure Regulation and Cardiovascular Disease

(2013) Roopashree Prabhushankar et al.   CURRENT HYPERTENSION REPORTS

Differential role of the estrogen receptors ESR1 and ESR2 on the regulation of proteins involved with proliferation and differentiation of Sertoli cells from 15-day-old rats

(2013) Thaís F.G. Lucas et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Selective GPER activation decreases proliferation and activates apoptosis in tumor Leydig cells

(2013) A Chimento et al.   Cell Death & Disease

Estrogen, a female hormone involved in spermatogenesis

(2012) S Carreau et al.   Advances in Medical Sciences

17Beta-Estradiol Signaling and Regulation of Proliferation and Apoptosis of Rat Sertoli Cells1

(2012) Carine Royer et al.   BIOLOGY OF REPRODUCTION

Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene

(2012) Carmela Guido et al.   CELL CYCLE

Minireview: G Protein-Coupled Estrogen Receptor-1, GPER-1: Its Mechanism of Action and Role in Female Reproductive Cancer, Renal and Vascular Physiology

(2012) Edward J. Filardo et al.   ENDOCRINOLOGY

17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line

(2012) Adele Chimento et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The contribution of proteomics to understanding epididymal maturation of mammalian spermatozoa

(2012) Jean-Louis Dacheux et al.   Systems Biology in Reproductive Medicine

Detection of aromatase, androgen, and estrogen receptors in bank vole spermatozoa

(2012) M. Kotula-Balak et al.   THERIOGENOLOGY

Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression

(2012) Zhi-Guo Sheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Association study and expression analysis of porcine ESR1 as a candidate gene for boar fertility and sperm quality

(2011) Asep Gunawan et al.   ANIMAL REPRODUCTION SCIENCE

GPR30 is overexpressed in post-puberal testicular germ cell tumors

(2011) Renato Franco et al.   CANCER BIOLOGY & THERAPY

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

(2011) Zhi-Guo Sheng et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Bisphenol A promotes testicular seminoma cell proliferation through GPER/GPR30

(2011) Nicolas Chevalier et al.   INTERNATIONAL JOURNAL OF CANCER

Estrogen and Its Receptors in Efferent Ductules and Epididymis

(2011) R. A. Hess et al.   JOURNAL OF ANDROLOGY

Estrogens promote proliferation of the seminoma-like TCam-2 cell line through a GPER-dependent ERα36 induction

(2011) Angelina Wallacides et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The G-protein-coupled estrogen receptor GPER in health and disease

(2011) Eric R. Prossnitz et al.   Nature Reviews Endocrinology

Estrogen receptors and function in the male reproductive system

(2010) Maria Fatima Magalhães Lazari et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Expression and Signaling of G Protein-Coupled Estrogen Receptor 1 (GPER) in Rat Sertoli Cells1

(2010) Thaís F. G. Lucas et al.   BIOLOGY OF REPRODUCTION

The G Protein-Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor-Positive Breast Cancer Cells

(2010) E. A. Ariazi et al.   CANCER RESEARCH

Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21 and induction of G2 cell-cycle arrest

(2010) Q K Y Chan et al.   CELL DEATH AND DIFFERENTIATION

Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man

(2010) K. Spinnler et al.   HUMAN REPRODUCTION

Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax

(2010) A. Chimento et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

17β-Estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ERα

(2010) Adele Chimento et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oestrogens and spermatogenesis

(2010) S. Carreau et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Aromatase gene expression in immature rat Sertoli cells: age-related changes in the FSH signalling pathway

(2010) Hélène Bouraïma-Lelong et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Regulatory Role of G Protein–Coupled Estrogen Receptor for Vascular Function and Obesity

(2009) Elvira Haas et al.   CIRCULATION RESEARCH

G Protein-Coupled Receptor 30: Estrogen Receptor or Collaborator?

(2009) Ellis R. Levin   ENDOCRINOLOGY

Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor

(2009) Adil Bouskine et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Leydig Cell Tumor of the Testis

(2009) Paul Jou et al.   JOURNAL OF UROLOGY

Mechanisms of estrogen signaling and gene expression via GPR30

(2009) Eric R. Prossnitz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER

(2009) Eric R. Prossnitz et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Identification of ERβ1 and ERβ2 in human seminoma, in embryonal carcinoma and in their adjacent intratubular germ cell neoplasia

(2009) Vittoria Rago et al.   Reproductive Biology and Endocrinology

The Novel Estrogen Receptor, G Protein-Coupled Receptor 30, Mediates the Proliferative Effects Induced by 17β-Estradiol on Mouse Spermatogonial GC-1 Cell Line

(2008) Rosa Sirianni et al.   ENDOCRINOLOGY

Exploring Human Testicular Peritubular Cells: Identification of Secretory Products and Regulation by Tumor Necrosis Factor-α

(2008) Christoph Schell et al.   ENDOCRINOLOGY

The ins and outs of GPR30: A transmembrane estrogen receptor

(2008) Eric R. Prossnitz et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of Steroid Hormone Biosynthesis by the Cytoskeleton

(2008) Marion B. Sewer et al.   LIPIDS

17Beta-Estradiol Induces the Translocation of the Estrogen Receptors ESR1 and ESR2 to the Cell Membrane, MAPK3/1 Phosphorylation and Proliferation of Cultured Immature Rat Sertoli Cells1

(2007) Thaís F.G. Lucas et al.   BIOLOGY OF REPRODUCTION

Estrogens Promote Human Testicular Germ Cell Cancer through a Membrane-Mediated Activation of Extracellular Regulated Kinase and Protein Kinase A

(2007) Adil Bouskine et al.   ENDOCRINOLOGY