Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance

Co-occurrence of plasmid-mediated tigecycline and carbapenem resistance in Acinetobacter spp. from waterfowls and their neighboring environment

(2020) Chao-Yue Cui et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel tigecycline resistance gene, tet(X6), on an SXT/R391 integrative and conjugative element in a Proteus genomospecies 6 isolate of retail meat origin

(2020) Dandan He et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of the novel tigecycline resistance gene tet(X6) and its variants in Myroides, Acinetobacter and Proteus of food animal origin

(2020) Dejun Liu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene tet(X)-Bearing Plasmidome among Bacteria

(2020) Ruichao Li et al.   mSystems

Emerging High‐Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X)

(2020) Liang‐Xing Fang et al.   BIOESSAYS

Cartography of opportunistic pathogens and antibiotic resistance genes in a tertiary hospital environment

(2020) Kern Rei Chng et al.   NATURE MEDICINE

Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

(2020) Andrew J. Gasparrini et al.   Communications Biology

Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene

(2020) Chengtao Sun et al.   Communications Biology

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

(2020) Rong Zhang et al.   Nature Communications

Rapid Detection of High-Level Tigecycline Resistance in Tet(X)-Producing Escherichia coli and Acinetobacter spp. Based on MALDI-TOF MS

(2020) Ze-Hua Cui et al.   Frontiers in Cellular and Infection Microbiology

Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species

(2020) Chong Chen et al.   Genome Medicine

Semisynthetic Analogues of Anhydrotetracycline as Inhibitors of Tetracycline Destructase Enzymes

(2019) Jana L. Markley et al.   ACS Infectious Diseases

Metagenomic insights into the distribution of antibiotic resistome between the gut-associated environments and the pristine environments

(2019) Jiaxiong Zeng et al.   ENVIRONMENT INTERNATIONAL

Interactive Tree Of Life (iTOL) v4: recent updates and new developments

(2019) Ivica Letunic et al.   NUCLEIC ACIDS RESEARCH

Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans

(2019) Tao He et al.   Nature Microbiology

Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli

(2019) Jian Sun et al.   Nature Microbiology

Detection of chromosome-mediated tet(X4)-carrying Aeromonas caviae in a sewage sample from a chicken farm

(2019) Chong Chen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

(2019) Liyuan Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Limited distribution and mechanism of the TetX4 tetracycline resistance enzyme

(2019) Yongchang Xu et al.   Science Bulletin

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

(2018) Andrew C. Pawlowski et al.   Nature Communications

Various Profiles of tet Genes Addition to tet(X) in Riemerella anatipestifer Isolates From Ducks in China

(2018) De-Kang Zhu et al.   Frontiers in Microbiology

Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes

(2017) Jooyoung Park et al.   Nature Chemical Biology

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

(2016) Mariano M. González et al.   MOLECULAR BIOLOGY AND EVOLUTION

Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance

(2015) Marius Linkevicius et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

(2014) T. Zou et al.   MOLECULAR BIOLOGY AND EVOLUTION

Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX

(2013) Gesa Volkers et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Multidrug-resistant tet(X)-containing hospital isolates in Sierra Leone

(2013) Tomasz A. Leski et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

(2013) Valeria A. Risso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

(2011) Gesa Volkers et al.   FEBS LETTERS

The tetracycline resistome

(2009) Maulik Thaker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES