Putative dioxygen-binding sites and recognition of tigecycline and minocycline in the tetracycline-degrading monooxygenase TetX

Tigecycline Resistance Can Occur Independently of theramAGene in Klebsiella pneumoniae

(2012) Mark Veleba et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

(2012) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance

(2012) K. Walkiewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The enigmatic reaction of flavins with oxygen

(2012) Pimchai Chaiyen et al.   TRENDS IN BIOCHEMICAL SCIENCES

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The history of the tetracyclines

(2011) Mark L. Nelson et al.   Annals of the New York Academy of Sciences

Definition and testing of the GROMOS force-field versions 54A7 and 54B7

(2011) Nathan Schmid et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

(2011) Gesa Volkers et al.   FEBS LETTERS

An Automated Force Field Topology Builder (ATB) and Repository: Version 1.0

(2011) Alpeshkumar K. Malde et al.   Journal of Chemical Theory and Computation

Recognition of Drug Degradation Products by Target Proteins: Isotetracycline Binding to Tet Repressor

(2011) Gesa Volkers et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorocyclines. 1. 7-Fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline: A Potent, Broad Spectrum Antibacterial Agent

(2011) Xiao-Yi Xiao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural consequences of ATP hydrolysis on the ABC transporter NBD dimer: Molecular dynamics studies of HlyB

(2011) João M. Damas et al.   PROTEIN SCIENCE

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystallization and preliminary X-ray crystallographic analysis of the tetracycline-degrading monooxygenase TetX2 fromBacteroides thetaiotaomicron

(2010) Gesa Volkers et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature

(2010) Michael O. Griffin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Roles of Salmonella multidrug efflux pumps in tigecycline resistance

(2010) T. Horiyama et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nonantibiotic Properties of Tetracyclines: Structural Basis for Inhibition of Secretory Phospholipase A2

(2010) Daniela Dalm et al.   JOURNAL OF MOLECULAR BIOLOGY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The tetracycline resistome

(2009) Maulik Thaker et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amadacycline

(2009) Y. Wang et al.   DRUGS OF THE FUTURE

Dioxygen and nitric oxide pathways and affinity to the catalytic site of rubredoxin:oxygen oxidoreductase from Desulfovibrio gigas

(2009) Bruno L. Victor et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Multiple pathways guide oxygen diffusion into flavoenzyme active sites

(2009) R. Baron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of Tetracyclines to Elongation Factor Tu, the Tet Repressor, and the Ribosome: A Molecular Dynamics Simulation Study†

(2008) Alexey Aleksandrov et al.   BIOCHEMISTRY

Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex

(2008) Gottfried J. Palm et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

P-LINCS:  A Parallel Linear Constraint Solver for Molecular Simulation

(2007) Berk Hess   Journal of Chemical Theory and Computation