Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

Solution NMR Spectroscopy for the Study of Enzyme Allostery

(2016) George P. Lisi et al.   CHEMICAL REVIEWS

Advances in free-energy-based simulations of protein folding and ligand binding

(2016) Alberto Perez et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

New Views of Functionally Dynamic Proteins by Solution NMR Spectroscopy

(2016) Lewis E. Kay   JOURNAL OF MOLECULAR BIOLOGY

Enzyme Dynamics from NMR Spectroscopy

(2015) Arthur G. Palmer   ACCOUNTS OF CHEMICAL RESEARCH

Negative Epistasis and Evolvability in TEM-1 β-Lactamase—The Thin Line between an Enzyme's Conformational Freedom and Disorder

(2015) Eynat Dellus-Gur et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features

(2015) María-Rocío Meini et al.   MOLECULAR BIOLOGY AND EVOLUTION

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme

(2015) Luciano A. Abriata et al.   PLoS One

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

(2015) Shrenik C. Mehta et al.   PLoS Pathogens

A mechanistic stress model of protein evolution accounts for site-specific evolutionary rates and their relationship with packing density and flexibility

(2014) Tsun-Tsao Huang et al.   BMC EVOLUTIONARY BIOLOGY

Dynamics and constraints of enzyme evolution

(2014) Miriam Kaltenbach et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Predicting Evolutionary Site Variability from Structure in Viral Proteins: Buriedness, Packing, Flexibility, and Design

(2014) Amir Shahmoradi et al.   JOURNAL OF MOLECULAR EVOLUTION

Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences throughout Evolutionary History

(2014) Valeria A. Risso et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evolution of Conformational Dynamics Determines the Conversion of a Promiscuous Generalist into a Specialist Enzyme

(2014) T. Zou et al.   MOLECULAR BIOLOGY AND EVOLUTION

Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution

(2014) Lizhi Ian Gong et al.   PLoS Genetics

Complete 1H, 15N and 13C resonance assignments of Bacillus cereus metallo-β-lactamase and its complex with the inhibitor R-thiomandelic acid

(2013) Andreas Ioannis Karsisiotis et al.   Biomolecular NMR Assignments

Epistasis Among Adaptive Mutations in Deer Mouse Hemoglobin

(2013) C. Natarajan et al.   SCIENCE

Stability-mediated epistasis constrains the evolution of an influenza protein

(2013) Lizhi Ian Gong et al.   eLife

Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling

(2012) Livnat Afriat-Jurnou et al.   BIOCHEMISTRY

Sequence-function-stability relationships in proteins from datasets of functionally annotated variants: The case of TEM β-lactamases

(2012) Luciano A. Abriata et al.   FEBS LETTERS

Sequence Evolution Correlates with Structural Dynamics

(2012) Ying Liu et al.   MOLECULAR BIOLOGY AND EVOLUTION

Epistasis as the primary factor in molecular evolution

(2012) Michael S. Breen et al.   NATURE

Amino acid coevolution induces an evolutionary Stokes shift

(2012) D. D. Pollock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interface of protein structure, protein biophysics, and molecular evolution

(2012) David A. Liberles et al.   PROTEIN SCIENCE

Automated NMR relaxation dispersion data analysis using NESSY

(2011) Michael Bieri et al.   BMC BIOINFORMATICS

A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis

(2011) G. Bhabha et al.   SCIENCE

Initial Mutations Direct Alternative Pathways of Protein Evolution

(2011) Merijn L. M. Salverda et al.   PLoS Genetics

Choreographing an enzyme's dance

(2010) Janice Villali et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase

(2009) C. J. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Probing Invisible, Low-Populated States of Protein Molecules by Relaxation Dispersion NMR Spectroscopy: An Application to Protein Folding

(2008) Dmitry M. Korzhnev et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance

(2008) Frédérique Maurice et al.   EMBO REPORTS

Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility

(2008) P. E. Tomatis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do viral proteins possess unique biophysical features?

(2008) Nobuhiko Tokuriki et al.   TRENDS IN BIOCHEMICAL SCIENCES

How Protein Stability and New Functions Trade Off

(2008) Nobuhiko Tokuriki et al.   PLoS Computational Biology