GABA transporter sustains IL-1β production in macrophages

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle

(2020) M. Zaeem Cader et al.   CELL

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

(2020) Abigail Jarret et al.   CELL

Human Mast Cell Proteome Reveals Unique Lineage, Putative Functions, and Structural Basis for Cell Ablation

(2020) Thomas Plum et al.   IMMUNITY

Orchestration of human macrophage NLRP3 inflammasome activation by Staphylococcus aureus extracellular vesicles

(2020) Xiaogang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

ASC and NLRP3 maintain innate immune homeostasis in the airway through an inflammasome-independent mechanism

(2019) Rendong Fang et al.   Mucosal Immunology

Metabolic adaptations of tissue-resident immune cells

(2019) George Caputa et al.   NATURE IMMUNOLOGY

GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity

(2019) Injae Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

(2019) Juan José Martínez-García et al.   Nature Communications

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription

(2019) Jing Guo et al.   Cellular & Molecular Immunology

Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

(2019) Liangliang Ji et al.   IMMUNITY

L-serine lowers the inflammatory responses during Pasteurella multocida infection

(2019) Fang He et al.   INFECTION AND IMMUNITY

One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

(2019) Weiwei Yu et al.   MOLECULAR CELL

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

(2019) P. Kent Langston et al.   NATURE IMMUNOLOGY

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

(2019) Ke-qi Fan et al.   CELL

Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24

(2019) Tao Yu et al.   Nature Communications

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

(2019) Teruo Kusano et al.   Nature Communications

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

(2019) Nicole Y. Lai et al.   CELL

Intestinal Epithelial Wnt Signaling Mediates Acetylcholine-Triggered Host Defense against Infection

(2018) Sid Ahmed Labed et al.   IMMUNITY

Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection

(2018) Wenkai Ren et al.   Mucosal Immunology

GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections

(2018) Jin Kyung Kim et al.   Nature Communications

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

(2017) Casey L Quinlan et al.   Nature Chemical Biology

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

(2017) Rojo A. Ratsimandresy et al.   Nature Communications

The microbiota protects against respiratory infection via GM-CSF signaling

(2017) Rebecca L. Brown et al.   Nature Communications

Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

(2017) Sachie Kanatani et al.   PLoS Pathogens

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes

(2016) Ben Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

GABAergic signalling in the immune system

(2015) A. Barragan et al.   Acta Physiologica

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

(2015) Gérald J. Prud'homme et al.   AUTOIMMUNITY REVIEWS

High homocysteine induces betaine depletion

(2015) A. Imbard et al.   BIOSCIENCE REPORTS

SnapShot: Immunometabolism

(2015) Peter J. Murray et al.   Cell Metabolism

Endogenous tissue factor pathway inhibitor has a limited effect on host defence in murine pneumococcal pneumonia

(2015) Cornelis van ’t Veer et al.   THROMBOSIS AND HAEMOSTASIS

 -Aminobutyric Acid Transporter 1 Negatively Regulates T Cell-Mediated Immune Responses and Ameliorates Autoimmune Inflammation in the CNS

(2014) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity

(2013) Hideki Hara et al.   NATURE IMMUNOLOGY

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cys2His2 zinc finger protein family: Classification, functions, and major members

(2012) S. V. Razin et al.   BIOCHEMISTRY-MOSCOW

GABAergic Signaling Is Linked to a Hypermigratory Phenotype in Dendritic Cells Infected by Toxoplasma gondii

(2012) Jonas M. Fuks et al.   PLoS Pathogens

An intrinsic GABAergic system in human lymphocytes

(2010) Leonardo Dionisio et al.   NEUROPHARMACOLOGY

Inhibitory role for GABA in autoimmune inflammation

(2010) R. Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Aminobutyric Acid Transporter 1 Negatively Regulates T Cell Activation and Survival through Protein Kinase C-Dependent Signaling Pathways

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Keep Your Fingers Off My DNA: Protein–Protein Interactions Mediated by C2H2 Zinc Finger Domains

(2008) Kathryn J. Brayer et al.   CELL BIOCHEMISTRY AND BIOPHYSICS