Article
Immunology
Suguru Saito, Duo-Yao Cao, Aaron R. Victor, Zhenzi Peng, Hui-Ya Wu, Derick Okwan-Duodu
Summary: RASAL3, a RasGAP highly expressed in neutrophils, negatively regulates cellular activity and modulates inflammatory response. Lack of RASAL3 leads to enhanced neutrophil responses, immune activation, and accelerated mortality in acute inflammatory conditions. RASAL3 has therapeutic potential in regulating excessive inflammation in sepsis and various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jordi Yang Zhou, Jens M. Werner, Gunther Glehr, Edward K. Geissler, James A. Hutchinson, Katharina Kronenberg
Summary: This study identifies and characterizes human Type II NKT (T2NKT) cells in blood and liver tissue, and provides strategies for enriching and expanding these rare cells. The researchers also discover a novel subset of T2NKT cells that stably expresses FoxP3, which might play a role in regulating lymphocyte responses in fatty liver transplants.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Liane Babes, Raymond Shim, Paul Kubes
Summary: Patients with colorectal cancer often develop liver metastases after surgery, which can be inhibited by prior intravenous injection of α-GalCer, although some tumor cells may survive. Multiple dosing of α-GalCer reduces tumor burden and prolongs survival, with increased number and activity of iNKT cells, suggesting a potential therapeutic benefit for patients with metastatic liver disease.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Ao Ren, Wenjing He, Jiawei Rao, Dongmei Ye, Pengrui Cheng, Qian Jian, Zongli Fu, Xuzhi Zhang, Ronghai Deng, Yifang Gao, Yi Ma
Summary: This study used single-cell RNA sequencing to analyze immune cells from patients with alcoholic cirrhosis and healthy controls, revealing fibrosis-associated macrophages and mucosal-associated invariant T cells that play important roles in the pathogenesis of liver cirrhosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, Myth T. S. Mok, Lingyun Zhang, Zhixian Liang, Xiaoyu Liu, Zhewen Xiong, Xuezhen Zeng, Jing Wang, Jiahuan Lu, Jingqing Li, Hanyong Sun, Xiaoyu Tian, Philip Chun Yeung, Yong Hou, Heung Man Lee, Candice C. H. Lam, Howard H. W. Leung, Anthony W. H. Chan, Ka Fai To, John Wong, Paul B. S. Lai, Kelvin K. C. Ng, Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Judith E. Allen
Summary: Type 2 immunity plays a crucial role in protecting against parasites and responding to allergens, as well as maintaining tissue integrity and promoting wound repair. IL-4 and IL-13, key type 2 cytokines, are involved in suppressing the initial inflammatory response to injury and modulating extracellular matrix changes for effective repair. However, the exact contribution of IL-4R alpha signaling in wound repair is still not fully understood due to redundancy and other signaling pathways.
ANNUAL REVIEW OF IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Long Xu, Yang Yang, Jiali Jiang, Yankai Wen, Jong-Min Jeong, Christoph Emontzpohl, Constance L. Atkins, Kangho Kim, Elizabeth A. Jacobsen, Hua Wang, Cynthia Ju
Summary: This study revealed that eosinophil-derived IL-4/IL-13 played a hepatoprotective role in acetaminophen-induced liver injury. The p38 MAPK/COX/NF-kappa B signaling cascade was shown to be critical in mediating the production of IL-4/IL-13 by eosinophils in response to IL-33.
Article
Immunology
Valeria Fumagalli, Valentina Venzin, Pietro Di Lucia, Federica Moalli, Xenia Ficht, Gioia Ambrosi, Leonardo Giustini, Francesco Andreata, Marta Grillo, Diletta Magini, Micol Rava, Christin Friedrich, Jason D. Fontenot, Philippe Bousso, Sarah A. Gilmore, Shahzada Khan, Manuel Baca, Eric Vivier, Georg Gasteiger, Mirela Kuka, Luca G. Guidotti, Matteo Iannacone
Summary: Group 1 innate lymphoid cells (ILCs) play a role in controlling T cell-mediated liver immunopathology by limiting local IL-2 concentration.
SCIENCE IMMUNOLOGY
(2022)
Article
Oncology
Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Areeb Rizwan, Fatima Faraz, Syeda Alveena Shah, Mahrukh Farooqi, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Suhail Razak
Summary: This study identified a positive association of IL-4 -590C/T and CTLA-4 + 49A/G gene polymorphisms with HCV-induced HCC in Pakistan. The findings may serve as genetic markers for HCC.
Article
Multidisciplinary Sciences
Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima
Summary: The study reveals that LXR alpha and LXR beta play essential roles in NKT cell-mediated immunity, such as cytokine production and hepatic antitumor activity, and are involved in NKT cell development in immune tissues, such as the thymus.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Anita Gola, Michael G. Dorrington, Emily Speranza, Claudia Sala, Rochelle M. Shih, Andrea J. Radtke, Harikesh S. Wong, Antonio P. Baptista, Jonathan M. Hernandez, Gastone Castellani, Iain D. C. Fraser, Ronald N. Germain
Summary: The study reveals that immune cells in the liver also exhibit zonation, which is regulated by microbiome sensing by liver sinusoidal endothelial cells and plays a crucial role in host defense. Immune cells concentrate asymmetrically around periportal regions in the liver, and this spatial polarization is more efficient in protecting against systemic bacterial dissemination compared to a uniform distribution. Liver sinusoidal endothelial cells actively sense the microbiome and orchestrate the localization of immune cells to optimize host defense.
Article
Medicine, General & Internal
Mohamed F. Mandour, Pyone Pyone Soe, Anne-Sophie Castonguay, Jacques Van Snick, Jean-Paul Coutelier
Summary: This study investigates the mechanisms by which the interaction between infectious agent molecules and early innate responses enhances the early inhibition of cancer growth, and specifically evaluates the role of Interleukin-12 (IL-12). The results show that CpG-protected mice against the early growth of plasmacytoma TEPC.1033.C2 cells through the ligation of toll-like receptor 9 (TLR9). This protection is dependent on IL-12 and gamma-interferon, and is confirmed in a model of early mesothelioma AB1 cell growth through the stimulation of TLR3 and TLR7/8.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Chang Jia, Yingzhi Zhuge, Shuchi Zhang, Chao Ni, Linlin Wang, Rongzhou Wu, Chao Niu, Zhengwang Wen, Xing Rong, Huixian Qiu, Maoping Chu
Summary: Kawasaki disease (KD) is an acute vasculitis that can lead to coronary artery aneurysms if untreated. Studies suggest that IL-37 may play a protective role in KD by reducing endothelial cell apoptosis and inflammation.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Hongyu Jia, Jianing Chen, Xujun Zhang, Kefan Bi, Hetong Zhou, Tianxing Liu, Jia Xu, Hongyan Diao
Summary: This study investigated the role of T cell subsets in primary biliary cholangitis (PBC) patients and found that these patients had higher levels of invariant natural killer T (iNKT) cells and CD3(+)CD56(+) alpha Galcer-CD1d tetramer(-) T cells compared to healthy controls. These T cell subsets also produced significantly higher levels of Interleukin-17A (IL-17A) in PBC patients and the levels were positively correlated with disease severity. The study also revealed that stimulation of autoantibodies in PBC patients increased the production of IL-17A by these T cell subsets, which promoted PBC-related fibrosis. These findings provide evidence-based diagnostic and therapeutic strategies for PBC patients.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Cell Biology
Cristhiane Favero Aguiar, Felipe Correa-da-Silva, Michelangelo Bauwelz Gonzatti, Monara Kaelle Angelim, Marco Antonio Pretti, Gustavo Gastao Davanzo, Bianca Gazieri Castelucci, Lauar Brito Monteiro, Gisele Castro, Joao Victor Virgilio-da-Silva, Guilherme Ribeiro, Vitor Jaccomo, Mirella C. Pereira Andrade, Webster Leonardo Costa, Victor Gambarini, Fernanda Fernandes Terra, Jose Carlos Alves-Filho, Niels Olsen Saraiva Camara, Mariana Boroni, Alexandre Castro Keller, Pedro M. Moraes-Vieira
Summary: This study reveals that splenic and hepatic iNKT cells rely on glycolytic metabolism, while adipose tissue iNKT cells have a distinctive immunometabolic profile involving AMPK. Deletion of the Pkm2 gene impairs the response and injury mitigation ability of splenic and hepatic iNKT cells, while AMPK deficiency affects the physiology and inflammation regulation ability of adipose tissue iNKT cells during obesity.
Article
Cell & Tissue Engineering
Masaya Higuchi, Hiroki Kawamura, Hideaki Matsuki, Toshifumi Hara, Masahiko Takahashi, Suguru Saito, Kousuke Saito, Shuying Jiang, Makoto Naito, Hiroshi Kiyonari, Masahiro Fujii
Article
Biochemical Research Methods
Amr Elguoshy, Yoshitoshi Hirao, Bo Xu, Suguru Saito, Ali F. Quadery, Keiko Yamamoto, Toshiaki Mitsui, Tadashi Yamamoto
JOURNAL OF PROTEOME RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Derick Okwan-Duodu, Daiana Weiss, Zhenzi Peng, Luciana C. Veiras, Duo-Yao Cao, Suguru Saito, Zakir Khan, Ellen A. Bernstein, Jorge F. Giani, W. Robert Taylor, Kenneth E. Bernstein
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Review
Peripheral Vascular Disease
Luciana C. Veiras, DuoYao Cao, Suguru Saito, Zhenzi Peng, Ellen A. Bernstein, Justin Z. Y. Shen, Maya Koronyo-Hamaoui, Derick Okwan-Duodu, Jorge F. Giani, Zakir Khan, Kenneth E. Bernstein
CURRENT HYPERTENSION REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Duo-Yao Cao, Weston R. Spivia, Luciana C. Veiras, Zakir Khan, Zhenzi Peng, Anthony E. Jones, Ellen A. Bernstein, Suguru Saito, Derick Okwan-Duodu, Sarah J. Parker, Jorge F. Giani, Ajit S. Divakaruni, Jennifer E. Van Eyk, Kenneth E. Bernstein
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Microbiology
Zhenzi Peng, Duo-Yao Cao, Hui-Ya Wu, Suguru Saito
Review
Biochemistry & Molecular Biology
Duo-Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan-Duodu, Ellen A. Bernstein, Jorge F. Giani, Kenneth E. Bernstein, Zakir Khan
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2020)
Article
Microbiology
Suguru Saito, Alato Okuno, Duo-Yao Cao, Zhenzi Peng, Hui-Ya Wu, Shu-Hui Lin
Article
Immunology
Suguru Saito, Duo-Yao Cao, Aaron R. Victor, Zhenzi Peng, Hui-Ya Wu, Derick Okwan-Duodu
Summary: RASAL3, a RasGAP highly expressed in neutrophils, negatively regulates cellular activity and modulates inflammatory response. Lack of RASAL3 leads to enhanced neutrophil responses, immune activation, and accelerated mortality in acute inflammatory conditions. RASAL3 has therapeutic potential in regulating excessive inflammation in sepsis and various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Physiology
DuoYao Cao, Suguru Saito
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Suguru Saito, Nanae Kakizaki, Alato Okuno, Toshio Maekawa, Noriko M. Tsuji
Article
Health Care Sciences & Services
Yoshitoshi Hirao, Naohiko Kinoshita, Bo Xu, Suguru Saito, Ali F. Quadery, Amr Elguoshy, Keiko Yamamoto, Tadashi Yamamoto
Article
Biochemical Research Methods
Suguru Saito, Yoshitoshi Hirao, Ali F. Quadery, Bo Xu, Amr Elguoshy, Hidehiko Fujinaka, Shohei Koma, Keiko Yamamoto, Tadashi Yamamoto
METHODS AND PROTOCOLS
(2019)
Article
Microbiology
Suguru Saito, Ali F. Quadery
Article
Biochemistry & Molecular Biology
Yoshitoshi Hirao, Suguru Saito, Hidehiko Fujinaka, Shigeru Miyazaki, Bo Xu, Ali F. Quadery, Amr Elguoshy, Keiko Yamamoto, Tadashi Yamamoto