Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

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Sporadic activation of an oxidative stress–dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies

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A Coupled Mathematical Model of the Intracellular Replication of Dengue Virus and the Host Cell Immune Response to Infection

(2020) Carolin Zitzmann et al.   Frontiers in Microbiology

Emergence of SARS-CoV-2 through recombination and strong purifying selection

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Spatiotemporal dynamics of innate immune signaling via RIG-I–like receptors

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Mechanistic modeling explains the dsRNA length-dependent activation of the RIG-I mediated immune response

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Translation and Replication Dynamics of Single RNA Viruses

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Multi-omic measurements of heterogeneity in HeLa cells across laboratories

(2019) Yansheng Liu et al.   NATURE BIOTECHNOLOGY

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling

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RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase

(2019) Samantha L. Schwartz et al.   Wiley Interdisciplinary Reviews-RNA

Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy

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Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

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Kinetic Modeling of Virus Growth in Cells

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The life cycle of non-polio enteroviruses and how to target it

(2018) Jim Baggen et al.   NATURE REVIEWS MICROBIOLOGY

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

An engineering design approach to systems biology

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Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes

(2017) Millie Shah et al.   MOLECULAR & CELLULAR PROTEOMICS

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Multiple truncated isoforms of MAVS prevent its spontaneous aggregation in antiviral innate immune signalling

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Gene‐specific correlation of RNA and protein levels in human cells and tissues

(2016) Fredrik Edfors et al.   Molecular Systems Biology

The Epidemiology of Hand, Foot and Mouth Disease in Asia

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Alteration of Antiviral Signalling by Single Nucleotide Polymorphisms (SNPs) of Mitochondrial Antiviral Signalling Protein (MAVS)

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Lateral association and elongation of vimentin intermediate filament proteins: A time-resolved light-scattering study

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Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments

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StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

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The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

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An analysis of critical factors for quantitative immunoblotting

(2015) Kevin A. Janes   Science Signaling

Experimentally guided models reveal replication principles that shape the mutation distribution of RNA viruses

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An analysis of critical factors for quantitative immunoblotting

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Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Biochemical Characterization of Recombinant Enterovirus 71 3C Protease with Fluorogenic Model Peptide Substrates and Development of a Biochemical Assay

(2014) Luqing Shang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Bicistronic MAVS Transcript Highlights a Class of Truncated Variants in Antiviral Immunity

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Ubiquitin-Like Protein ISG15 (Interferon-Stimulated Gene of 15 kDa) in Host Defense Against Heart Failure in a Mouse Model of Virus-Induced Cardiomyopathy

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Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Single-Cell Analysis Uncovers Extensive Biological Noise in Poliovirus Replication

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Picornavirus Morphogenesis

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Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

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An ERK-p38 Subnetwork Coordinates Host Cell Apoptosis and Necrosis during Coxsackievirus B3 Infection

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Models of signalling networks - what cell biologists can gain from them and give to them

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Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle

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Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

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Quantitative Genomic and Antigenomic Enterovirus RNA Detection in Explanted Heart Tissue Samples from Patients with End-Stage Idiopathic Dilated Cardiomyopathy

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Alanine Scanning of Poliovirus 2CATPaseReveals New Genetic Evidence that Capsid Protein/2CATPaseInteractions Are Essential for Morphogenesis

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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

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In Vitro Assembly of an Empty Picornavirus Capsid follows a Dodecahedral Path

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NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells

(2012) Qian Feng et al.   Cell Reports

Convergent Evolution of Escape from Hepaciviral Antagonism in Primates

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

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A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

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A diverse range of gene products are effectors of the type I interferon antiviral response

(2011) John W. Schoggins et al.   NATURE

A public genome-scale lentiviral expression library of human ORFs

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The Transformation of Enterovirus Replication Structures: a Three-Dimensional Study of Single- and Double-Membrane Compartments

(2011) R. W. A. L. Limpens et al.   mBio

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

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Characterization of the Elongation Complex of Dengue Virus RNA Polymerase

(2010) Zhinan Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Protein Kinase R in the Interferon Response

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Direct Interaction between Two Viral Proteins, the Nonstructural Protein 2CATPase and the Capsid Protein VP3, Is Required for Enterovirus Morphogenesis

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edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

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MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

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Molecular Biology and Pathogenesis of Viral Myocarditis

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Development of a Taqman RT-PCR assay for the detection and quantification of negatively stranded RNA of human enteroviruses: Evidence for false-priming and improvement by tagged RT-PCR

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Poliovirus 2APro Increases Viral mRNA and Polysome Stability Coordinately in Time with Cleavage of eIF4G

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Modification of intracellular membrane structures for virus replication

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