The toxic side of one-carbon metabolism and epigenetics

In Vivo Rate of Formaldehyde Condensation with Tetrahydrofolate

(2020) Hai He et al.   Metabolites

Amino acid dependent formaldehyde metabolism in mammals

(2020) Matthias Pietzke et al.   Communications Chemistry

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans

(2020) Felix A. Dingler et al.   MOLECULAR CELL

Formate metabolism in health and disease

(2019) Matthias Pietzke et al.   Molecular Metabolism

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Impact of One Carbon Metabolism on Histone Methylation

(2019) Magdalini Serefidou et al.   Frontiers in Genetics

Glutathione deficiency induces epigenetic alterations of vitamin D metabolism genes in the livers of high-fat diet-fed obese mice

(2019) Rajesh Parsanathan et al.   Scientific Reports

Nuclear Folate Metabolism

(2018) Martha S. Field et al.   Annual Review of Nutrition

Mitochondrial translation requires folate-dependent tRNA methylation

(2018) Raphael J. Morscher et al.   NATURE

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

(2018) Yuxiang Zheng et al.   CELL

Dynamic regulation of epigenetic demethylation by oxygen availability and cellular redox

(2018) Nermina Lamadema et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

(2017) Guillermo Burgos-Barragan et al.   NATURE

Formaldehyde Is a Potent Proteotoxic Stressor Causing Rapid Heat Shock Transcription Factor 1 Activation and Lys48-Linked Polyubiquitination of Proteins

(2016) Sara Ortega-Atienza et al.   AMERICAN JOURNAL OF PATHOLOGY

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway

(2016) Gregory S. Ducker et al.   Cell Metabolism

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

(2016) Julian Stingele et al.   MOLECULAR CELL

A PDI-catalyzed thiol–disulfide switch regulates the production of hydrogen peroxide by human Ero1

(2015) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

(2015) Lucas B. Pontel et al.   MOLECULAR CELL

Disruption of DNA Methylation via S-Adenosylhomocysteine Is a Key Process in High Incidence Liver Carcinogenesis in Fish

(2013) Leda Mirbahai et al.   JOURNAL OF PROTEOME RESEARCH

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway

(2013) Rima Obeid   Nutrients

Mechanism of Inhibition for N6022, a First-in-Class Drug Targeting S-Nitrosoglutathione Reductase

(2012) Louis S. Green et al.   BIOCHEMISTRY

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis

(2012) Bruce Morgan et al.   Nature Chemical Biology

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Molecular mechanisms and potential functions of histone demethylases

(2012) Susanne Marije Kooistra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

S-adenosylmethionine in Liver Health, Injury, and Cancer

(2012) Shelly C. Lu et al.   PHYSIOLOGICAL REVIEWS

The Intestinal Absorption of Folates

(2011) Michele Visentin et al.   Annual Review of Physiology

Histone Demethylase LSD1 Is a Folate-Binding Protein

(2011) Zigmund Luka et al.   BIOCHEMISTRY

Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease

(2011) Marc Fransen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

(2011) Elena J. Tucker et al.   Cell Metabolism

Competition between Sumoylation and Ubiquitination of Serine Hydroxymethyltransferase 1 Determines Its Nuclear Localization and Its Accumulation in the Nucleus

(2011) Donald D. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

(2011) Ivan V Rosado et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

(2011) D. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

(2010) Anne S. Tibbetts et al.   Annual Review of Nutrition

Distribution of DNA Adducts Caused by Inhaled Formaldehyde Is Consistent with Induction of Nasal Carcinoma but Not Leukemia

(2010) Kun Lu et al.   TOXICOLOGICAL SCIENCES

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

Structure-function relationships in methionine adenosyltransferases

(2008) G. D. Markham et al.   CELLULAR AND MOLECULAR LIFE SCIENCES