GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease

Cardioprotective GLP-1 metabolite prevents ischemic cardiac injury by inhibiting mitochondrial trifunctional protein-α

(2020) M. Ahsan Siraj et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Impaired Glucose Tolerance and Reduced Plasma Insulin Precede Decreased AKT Phosphorylation and GLUT3 Translocation in the Hippocampus of Old 3xTg-AD Mice

(2019) Chelsea M. Griffith et al.   JOURNAL OF ALZHEIMERS DISEASE

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes

(2019) Shaimaa Mahmoud et al.   Cells

A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease

(2019) Sung Hoon Baik et al.   Cell Metabolism

Liraglutide improves insulin sensitivity in high fat diet induced diabetic mice through multiple pathways

(2019) Joseph Yi Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon-like peptide-1 suppresses neuroinflammation and improves neural structure

(2019) Gwangho Yoon et al.   PHARMACOLOGICAL RESEARCH

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

Recurrent non-severe hypoglycemia exacerbates imbalance of mitochondrial homeostasis leading to synapse injury and cognitive deficit in diabetes

(2018) Yu Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Protective effects of the GLP-1 mimetic exendin-4 in Parkinson's disease

(2018) Dilan Athauda et al.   NEUROPHARMACOLOGY

Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models

(2018) Christian Hölscher   NEUROPHARMACOLOGY

Triple GLP-1/GIP/glucagon receptor agonists, a potential novel treatment strategy in Alzheimer’s disease

(2018) Antoni Camins et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

(2018) Mao Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

(2017) Rodrigo Carlessi et al.   Scientific Reports

Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine

(2017) Manuel van Gijsel-Bonnello et al.   PLoS One

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis

(2016) R. A. Harris et al.   JOURNAL OF NEUROSCIENCE

Peripheral administration of lactate produces antidepressant-like effects

(2016) A Carrard et al.   MOLECULAR PSYCHIATRY

Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies

(2016) Mithilesh Kumar Jha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy

(2016) Shota Sasagawa et al.   Frontiers in Pharmacology

Protection of pancreatic β-cells against glucotoxicity by short-term treatment with GLP-1

(2015) Sun-Hyun Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Combination therapy with remote ischaemic conditioning and insulin or exenatide enhances infarct size limitation in pigs

(2015) Juan José Alburquerque-Béjar et al.   CARDIOVASCULAR RESEARCH

Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity

(2015) Wen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 by PI3K signaling

(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

Glycolytic enzyme upregulation and numbness of mitochondrial activity characterize the early phase of apoptosis in cerebellar granule cells

(2014) A. Bobba et al.   APOPTOSIS

Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: Differences and similarities

(2014) Asger Lund et al.   European Journal of Internal Medicine

Cortical hypermetabolism in MCI subjects: a compensatory mechanism?

(2014) A. Ashraf et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Glutathione-Dependent Detoxification Processes in Astrocytes

(2014) Ralf Dringen et al.   NEUROCHEMICAL RESEARCH

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

High-Throughput Direct Fecal PCR Assay for Detection of Mycobacterium avium subsp. paratuberculosis in Sheep and Cattle

(2013) K. M. Plain et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The inverse association of cancer and Alzheimer's: a bioenergetic mechanism

(2013) L. A. Demetrius et al.   Journal of the Royal Society Interface

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

(2010) Sybille Mazurek   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES