Article
Immunology
Brandilyn A. Peters, Lila A. Sheira, David B. Hanna, Qibin Qi, Anjali Sharma, Adebola Adedimeji, Tracey Wilson, Daniel Merenstein, Phyllis C. Tien, Mardge Cohen, Eryka L. Wentz, Jennifer Kinslow, Alan L. Landay, Sheri D. Weiser
Summary: Food insecurity is associated with increased immune activation, senescence, and decreased co-stimulation in women with HIV on antiretroviral therapy. The relationship remains significant regardless of HIV viral load control status. Reducing food insecurity may be crucial in decreasing non-AIDS-related disease risk in this population.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Carey L. Shive, Michael L. Freeman, Souheil-Antoine Younes, Corinne M. Kowal, David H. Canaday, Benigno Rodriguez, Michael M. Lederman, Donald D. Anthony
Summary: HIV-infected immune non-responders (INR) exhibit higher proportions of CD4 T cell subsets expressing markers of exhaustion and senescence, as well as elevated plasma levels of IL-6, IP10, and sCD14. INR have higher levels of IP10 and lower levels of TGF-beta, with decreased cycling proportions of CD4 T regulatory cells. Proportions of T cells expressing TIGIT, PD-1, and CD57 positively correlate with IL-6 levels, while TGF-beta levels negatively correlate with proportions of TIGIT+ and PD-1+ T cell subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kwasi Adu-Berchie, Joshua M. Brockman, Yutong Liu, Tania W. To, David K. Y. Zhang, Alexander J. Najibi, Yoav Binenbaum, Alexander Stafford, Nikolaos Dimitrakakis, Miguel C. Sobral, Maxence O. Dellacherie, David J. Mooney
Summary: In this study, a hydrogel was developed to deliver adoptively transferred T cells to the tumor site and recruit and activate host antigen-presenting cells. The localized cell depots containing T cells showed significantly better control of subcutaneous tumors compared to other delivery methods. The combination of T cell delivery and biomaterial-driven activation of host immune cells prolonged T cell activation and enabled long-term tumor control.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Jun Song, Xiaofang Yi, Ruolin Gao, Li Sun, Zhixuan Wu, Shuling Zhang, Letian Huang, Chengbo Han, Jietao Ma
Summary: Tumor immunotherapy has made breakthroughs in recent years, but only a subset of patients respond. The tumor microenvironment may contribute to T cell exhaustion. Studies have shown that mitochondrial dynamics play an important role in the immune surveillance of T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yee Teng Chan, Heng Choon Cheong, Ting Fang Tang, Reena Rajasuriar, Kian-Kai Cheng, Chung Yeng Looi, Won Fen Wong, Adeeba Kamarulzaman
Summary: The progressive decline of CD8(+) cytotoxic T cells in HIV-infected patients due to cell exhaustion and cell death is associated with disease severity and progression into AIDS. T cell exhaustion is characterized by increased expression of immune checkpoint molecules, which hinder T cell receptor signaling and impair T cell activities. Glucose metabolism plays a crucial role in regulating T cell function and transitioning from an active to an exhausted state. Understanding the interplay between immune checkpoint molecules and glucose metabolism could aid in the development of novel therapeutic strategies for chronic HIV infection.
Article
Immunology
Kristina Berg Lorvik, Malin Holm Meyer-Myklestad, Kushi Kushekar, Charlotte Handeland, Asle Wilhelm Medhus, Marius Lund-Iversen, Birgitte Stiksrud, Dag Kvale, Anne Margarita Dyrhol-Riise, Kjetil Tasken, Dag Henrik Reikvam
Summary: The study found that immunological non-responders (INR) had a higher fraction of gut-homing CD4(+) T cells in the blood, which were more likely to display signs of exhaustion. Exhaustion of CD4(+) T cells increased in INR and correlated with markers of enterocyte damage in the gut.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kun Li, Ziqiang Wang
Summary: This review focuses on the roles and underlying mechanisms of microRNAs and long non-coding RNAs in regulating T cell exhaustion during chronic viral infections and tumorigenesis. The identification of these molecular targets can provide guidance for the development of more precise and effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jonas Leonhard, Matthias Schaier, Florian Kaelble, Martin Zeier, Andrea Steinborn
Summary: Immunosuppressive therapy increases the risk of non-melanoma skin cancer in elderly kidney transplant recipients. The therapy inhibits the differentiation of CD8(+) regulatory T cells more than that of CD8(+) responder T cells, resulting in exhausted Tresp profile and reduced cancer immunity in elderly KTR.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Aleksei Titov, Yaroslav Kaminskiy, Irina Ganeeva, Ekaterina Zmievskaya, Aygul Valiullina, Aygul Rakhmatullina, Alexey Petukhov, Regina Miftakhova, Albert Rizvanov, Emil Bulatov
Summary: This article discusses the mechanisms and impacts of T cell dysfunction in adoptive cell therapy, introducing different types of T cell exhaustion and senescence, as well as the role of CAR-T cells in treatment. Additionally, recent efforts to alleviate CAR-T cell exhaustion are explored.
Article
Immunology
Wanxue He, Kun Xiao, Jiaruo Xu, Wei Guan, Sheling Xie, Kaifei Wang, Peng Yan, Min Fang, Lixin Xie
Summary: Sepsis is a life-threatening disease caused by infection, with recurrent sepsis exacerbating CD4(+) T cell exhaustion and reducing antiviral immune responses, leading to increased disease severity and mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yueting Huang, Huijian Zheng, Yuwen Zhu, Yan Hong, Jie Zha, Zhijuan Lin, Zhifeng Li, Caiyan Wang, Zhihong Fang, Xingxing Yu, Long Liu, Bing Xu
Summary: Despite evidence of T-cell exhaustion in AML, immunotherapeutic targeting exhausted T cells such as PD-1 blockade failed to achieve satisfying efficacy. Characterization of exhausted T cells in AML is still needed.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Fei Sun, Tian-Tian Yue, Chun-Liang Yang, Fa-Xi Wang, Jia-Hui Luo, Shan-Jie Rong, Meng Zhang, Yanchao Guo, Fei Xiong, Cong-Yi Wang
Summary: The functional state of T cells is diverse and under dynamic control, with reversible protein phosphorylation playing a crucial role. Dual specific phosphatases (DUSPs) have emerged as versatile regulators in T cell biology, impacting effector T cell activity, T cell development, and other processes. DUSP proteins could potentially become a druggable target for various diseases, offering an alternative to current therapies focused on protein kinase activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Nikos Kourtis, Qingqing Wang, Bei Wang, Erin Oswald, Christina Adler, Samvitha Cherravuru, Evangelia Malahias, Lance Zhang, Jacquelynn Golubov, Qiaozhi Wei, Samantha Lemus, Min Ni, Yueming Ding, Yi Wei, Gurinder S. Atwal, Gavin Thurston, Lynn E. Macdonald, Andrew J. Murphy, Ankur Dhanik, Matthew A. Sleeman, Scott S. Tykodi, Dimitris Skokos
Summary: This study maps the chromatin landscape of immune cells in patients with early-stage clear cell renal cell carcinoma (ccRCC) and identifies the association between NF-kappa B and dysfunction in CD8(+) T cells. Importantly, it provides a valuable resource for understanding the functional states and regulatory dynamics of immune cells in ccRCC.
Review
Biochemistry & Molecular Biology
Melanie Kaiser, Maria Donatella Semeraro, Markus Herrmann, Gudrun Absenger, Armin Gerger, Wilfried Renner
Summary: As we age, immune functions decline while the incidence of cancer rises. The emergence of immune checkpoint blockade has revolutionized cancer therapy and sparked interest in identifying predictive biomarkers for treatment response. Age-related changes in the adaptive immune system, particularly T cells, have implications for carcinogenesis and response to immune checkpoint blockade.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Remi Bunet, Manon Nayrac, Hardik Ramani, Mohamed Sylla, Madeleine Durand, Carl Chartrand-Lefebvre, Jean-Pierre Routy, Alan L. Landay, Jean-Francois Gauchat, Nicolas Chomont, Petronela Ancuta, Daniel E. Kaufmann, Nicole Bernard, Cecile L. Tremblay, Mohamed El-Far
Summary: The downregulation of CD96 on CD8(+) T cells in people living with HIV is associated with impaired cellular responses to HIV antigens, as well as indicators of cell senescence and dysfunction. The expression of CD96 may serve as a biomarker for senescence and dysfunction in CD8(+) T cells in PLWH.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Madison Schank, Juan Zhao, Jonathan P. Moorman, Zhi Q. Yao
Summary: HIV infection and ART treatment can lead to mitochondrial dysfunction, which contributes to cellular exhaustion, senescence, and apoptosis. The compromised mitochondria result in decreased energy production, oxidative stress, and ultimately cellular dysfunction, impacting the overall health and aging of people living with HIV. Identifying and understanding these mechanisms may help in developing improved therapeutics for treating PLHIV.
Article
Multidisciplinary Sciences
Ling Wang, Juan Zhao, Lam N. T. Nguyen, James L. Adkins, Madison Schank, Sushant Khanal, Lam N. Nguyen, Xindi Dang, Dechao Cao, Bal Krishna Chand Thakuri, Zeyuan Lu, Jinyu Zhang, Yi Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
Summary: High titers of IgG neutralizing antibodies in COVID-19 convalescent plasma can block virus entry and fusion mediated by SARS-CoV-2-S, suggesting its potential as a preventive and therapeutic agent against SARS-CoV-2 and other SARS-CoV infections.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Summary: Genetic risk factors shared between Alzheimer's disease (AD) and cardiometabolic traits were identified in this study, revealing a complex genetic relationship between them. The results suggest that blood pressure and immune response play a role in the pleiotropy between these traits, potentially providing clues for discovering new therapeutic targets.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Niamh Mullins, JooEun Kang, Adrian Campos, Jonathan R. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark Adams, Swapnil Awasthi, Michael Ganda, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi-Chung Chen, Steven Crawford, Scott Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernandez-Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai-Gwo Hwu, Sonia Jain, Stephane Jamain, Susana Jimenez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly L. Klump, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih-Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy M. Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, Maria Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H. D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas Craddock, David Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Justine M. Gatt, Pablo Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Steven P. Hamilton, Marian L. Hamshere, Annette Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie-Odile Krebs, Mikael Lander, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Mueller-Myhsok, Caroline Nievergelt, Vishwajit Nimgaonkar, Markus M. Noethen, Michael C. O'Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W. J. H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribases, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Dan Rujescu, Cristina Sanchez-Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J. S. Sonuga-Barke, Gianfranco Spalletta, John S. Strauss, Beata Swiatkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar-Ribo, John B. Vincent, Henry Voelzke, James T. R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley-Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Borglum, Gerome Breen, Annette Erlangsen, Tonu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po-Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Renteria, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia Willour, Douglas M. Ruderfer
Summary: A genome-wide association study identified significant genetic loci associated with suicide attempts, particularly one locus on chromosome 7 which is implicated in risk-taking behavior, smoking, and insomnia. The study also revealed strong genetic correlations between suicide attempts and psychiatric disorders, as well as other nonpsychiatric traits like smoking, pain, and lower socioeconomic status. Conditioning on psychiatric disorders reduced the genetic correlations between suicide attempts and psychiatric disorders, indicating a shared biology with nonpsychiatric risk factors.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Adriana M. Hung, Shailja C. Shah, Alexander G. Bick, Zhihong Yu, Hua-Chang Chen, Christine M. Hunt, Frank Wendt, Otis Wilson, Robert A. Greevy, Cecilia P. Chung, Ayako Suzuki, Yuk-Lam Ho, Elvis Akwo, Renato Polimanti, Jin Zhou, Peter Reaven, Philip S. Tsao, J. Michael Gaziano, Jennifer E. Huffman, Jacob Joseph, Shiuh-Wen Luoh, Sudha Iyengar, Kyong-Mi Chang, Juan P. Casas, Michael E. Matheny, Christopher J. O'Donnell, Kelly Cho, Ran Tao, Katalin Susztak, Cassianne Robinson-Cohen, Sony Tuteja, Edward D. Siew
Summary: This study found that the risk group with two APOL1 high-risk genetic variants (G1 or G2) in individuals of African ancestry have a higher risk of developing COVID-19-associated AKI and death.
JAMA INTERNAL MEDICINE
(2022)
Review
Immunology
Justin M. Brueggeman, Juan Zhao, Madison Schank, Zhi Q. Yao, Jonathan P. Moorman
Summary: Effectively treating COVID-19 requires a comprehensive understanding of SARS-CoV-2 infection and the use of immune system modulators to enhance innate immune protection. The concept of trained immunity, which has been studied prior to the pandemic, involves training innate immune cells to produce a stronger immune response upon reactivation. This review discusses various immune training agents and cell types involved in trained immunity, as well as the potential of trained immunity in fighting SARS-CoV-2 infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Stella C. Ogbu, Samuel Rojas, John Weaver, Phillip R. Musich, Jinyu Zhang, Zhi Q. Yao, Yong Jiang
Summary: Breast cancer is a prevalent cancer in women, and therapeutic resistance to chemotherapy is a major challenge in improving the treatment outcomes. A protein kinase called DSTYK has been found to play a crucial role in promoting chemoresistance in breast cancer cells, particularly in triple-negative breast cancer. This discovery provides valuable insights and lays the foundation for developing new strategies targeting DSTYK to enhance the efficacy of TNBC therapy.
Article
Genetics & Heredity
Minsu Kim, Jennifer E. Huffman, Amy Justice, Ian Goethert, Greeshma Agasthya, Ioana Danciu
Summary: To our knowledge, this is the first attempt to use a network representation learning approach to learn associations among genomic variations within genes. Associations learned in this way can lead to an understanding of the underlying mechanisms of how genomic variations cooperatively affect each cancer phenotype.
BMC MEDICAL GENOMICS
(2022)
Article
Cell Biology
Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Xiao Y. Wu, Yi Zhang, Jinyu Zhang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Summary: This study found that the inhibition of TRF2 expression, rather than telomerase disruption, is responsible for CD4T cell dysfunction in chronic viral infections. Restoring TRF2 may present a novel approach to prevent telomeric DNA damage and premature T-cell aging.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemical Research Methods
Juan Zhao, Madison Schank, Ling Wang, Xindi Dang, Dechao Cao, Sushant Khanal, Lam N. T. Nguyen, Yi Zhang, Xiao Y. Wu, James L. Adkins, Benjamin J. Pelton, Jinyu Zhang, Shunbin Ning, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Summary: This study found that inflammatory proteins remain dysregulated in COVID-19 survivors and may serve as potential biomarkers for systemic inflammation. CXCL10, in particular, may be a potential biomarker for distinguishing long-haul COVID-19 patients.
PROTEOMICS CLINICAL APPLICATIONS
(2022)
Correction
Immunology
Dechao Cao, Sushant Khanal, Ling Wang, Zhengke Li, Juan Zhao, Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Xindi Dang, Madison Schank, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Zheng D. Morrison, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ling Wang, Juan Zhao, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Lam N. T. Nguyen, Yi Zhang, Xiao Y. Wu, James L. Adkins, Justin Brueggeman, Jinyu Zhang, Shunbin Ning, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Summary: Identification of three linear B-cell epitopes on the SARS-CoV-2 proteome that elicit neutralizing antibodies. Two of the epitopes showed strong reactivity at the early phase of COVID-19, while one epitope showed reactivity at a later phase. Stimulation of B cells with SARS-CoV-2 S peptides resulted in poor virus-specific B cell activation, proliferation, differentiation into memory B cells, and production of immunoglobulin G (IgG) antibodies, despite the B cells being functionally competent.
MOLECULAR IMMUNOLOGY
(2022)
Article
Virology
Sushant Khanal, Dechao Cao, Jinyu Zhang, Yi Zhang, Madison Schank, Xindi Dang, Lam Ngoc Thao Nguyen, Xiao Y. Wu, Yong Jiang, Shunbin Ning, Juan Zhao, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Summary: This study developed a novel HIV gene therapy using synthetic gRNA/Cas9 RNP as a non-viral formulation. The HIV-gRNA/Cas9 RNP effectively suppressed viral replication without apparent cytotoxicity. This study provides proof-of-concept for the use of synthetic gRNA/Cas9 RNP drugs as a novel therapeutic approach for HIV eradication.
Article
Immunology
Xindi Dang, Dechao Cao, Juan Zhao, Madison Schank, Sushant Khanal, Lam Ngoc Thao Nguyen, Xiao Y. Wu, Yi Zhang, Jinyu Zhang, Yong Jiang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Zhi Q. Yao
Summary: This study investigated the role of mitochondrial topoisomerase 1 (Top1mt) inhibition in T cell dysfunction during viral infections. The results showed that Top1mt inhibition leads to mitochondrial dysfunction, T cell dysregulation, and cell death. This highlights the importance of Top1 in maintaining T cell function during chronic viral infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander E. Katz, Min-Lee Yang, Michael G. Levin, Catherine Tcheandjieu, Michael Mathis, Kristina Hunker, Susan Blackburn, Jonathan L. Eliason, Dawn M. Coleman, Natalia Fendrikova-Mahlay, Heather L. Gornik, Monita Karmakar, Hannah Hill, Chang Xu, Matthew Zawistowski, Chad M. Brummett, Sebastian Zoellner, Xiang Zhou, Christopher J. O'Donnell, Julie A. Douglas, Themistocles L. Assimes, Phillip S. Tsao, Jun Z. Li, Scott M. Damrauer, James C. Stanley, Santhi K. Ganesh
Summary: Family members of individuals with multifocal fibromuscular dysplasia (FMD) may have an increased risk of arterial diseases. This study found that FMD, aneurysms, and dissections occurred in a significant proportion of first-degree relatives of FMD probands. The polygenic risk scores for FMD and abdominal aortic aneurysm (AAA) were associated with each other, indicating a shared genetic architecture. Screening for AAA may be justified in family members of individuals with FMD.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)