Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV

The Impact of HIV- and ART-Induced Mitochondrial Dysfunction in Cellular Senescence and Aging

(2021) Madison Schank et al.   Cells

Long Non-coding RNA GAS5 Regulates T Cell Functions via miR21-Mediated Signaling in People Living With HIV

(2021) Lam Ngoc Thao Nguyen et al.   Frontiers in Immunology

Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection

(2020) Xindi Dang et al.   Cell Death & Disease

Telomere and ATM Dynamics in CD4 T-Cell Depletion in Active and Virus-Suppressed HIV Infections

(2020) Sushant Khanal et al.   JOURNAL OF VIROLOGY

Telomeric injury by KML001 in human T cells induces mitochondrial dysfunction through the p53-PGC-1α pathway

(2020) Madison Schank et al.   Cell Death & Disease

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

(2019) Yinyin Li et al.   Cell Metabolism

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

(2019) Yingjie Ji et al.   Immunity & Ageing

Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions

(2019) Dechao Cao et al.   Frontiers in Immunology

Mitochondria as central hub of the immune system

(2019) Cristiane Naffah de Souza Breda et al.   Redox Biology

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy

(2019) Juan Zhao et al.   Frontiers in Immunology

Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections

(2018) Eleni Panagioti et al.   Frontiers in Immunology

Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection

(2018) Juan Zhao et al.   Cell Discovery

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection

(2018) Lam Nhat Nguyen et al.   Cell Death & Disease

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection

(2018) José Carlos Valle-Casuso et al.   Cell Metabolism

Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction

(2018) Souheil-Antoine Younes et al.   JOURNAL OF CLINICAL INVESTIGATION

CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions

(2018) Judd F. Hultquist et al.   Nature Protocols

Human Immunodeficiency Virus and Aging in the Era of Effective Antiretroviral Therapy

(2017) Puja Van Epps et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Pathophysiology of CD4+ T-Cell Depletion in HIV-1 and HIV-2 Infections

(2017) K. K. Vidya Vijayan et al.   Frontiers in Immunology

Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor CD4+ T-cell recovery

(2016) Thao P. Nguyen et al.   AIDS

Premature aging and immune senescence in HIV-infected children

(2016) Ketty Gianesin et al.   AIDS

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Ageing and inflammation in patients with HIV infection

(2016) M. Nasi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Emerging Role and Characterization of Immunometabolism: Relevance to HIV Pathogenesis, Serious Non-AIDS Events, and a Cure

(2016) Clovis S. Palmer et al.   JOURNAL OF IMMUNOLOGY

T-Cell Activation Independently Associates With Immune Senescence in HIV-Infected Recipients of Long-term Antiretroviral Treatment

(2016) Viviana Cobos Jiménez et al.   JOURNAL OF INFECTIOUS DISEASES

Protection of CD4 + T cells from hepatitis C virus infection-associated senescence via ΔNp63–miR-181a–Sirt1 pathway

(2016) Yun Zhou et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

HIV, Aging, and Viral Coinfections: Taking the Long View

(2016) Tamar H. Taddei et al.   Current HIV/AIDS Reports

Mitochondria: The Cellular Hub of the Dynamic Coordinated Network

(2015) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Shorter Telomere Length Predicts Poorer Immunological Recovery in Virologically Suppressed HIV-1–Infected Patients Treated With Combined Antiretroviral Therapy

(2015) José-Ramón Blanco et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Mitochondrial Metabolism in T Cell Activation and Senescence: A Mini-Review

(2014) Noga Ron-Harel et al.   GERONTOLOGY

Inflammatory Cytokines Drive CD4+ T-Cell Cycling and Impaired Responsiveness to Interleukin 7: Implications for Immune Failure in HIV Disease

(2014) Carey L. Shive et al.   JOURNAL OF INFECTIOUS DISEASES

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

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(2012) Mudit Tyagi et al.   MOLECULAR MEDICINE

Axis of ageing: telomeres, p53 and mitochondria

(2012) Ergün Sahin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunologic Failure Despite Suppressive Antiretroviral Therapy Is Related to Activation and Turnover of Memory CD4 Cells

(2011) Michael M. Lederman et al.   JOURNAL OF INFECTIOUS DISEASES

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy

(2010) Stefania Piconi et al.   AIDS

Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: A cohort study

(2010) Frederik N Engsig et al.   BMC INFECTIOUS DISEASES

Incomplete Reconstitution of T Cell Subsets on Combination Antiretroviral Therapy in the AIDS Clinical Trials Group Protocol 384

(2009) Gregory K. Robbins et al.   CLINICAL INFECTIOUS DISEASES

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection

(2008) Jason V Baker et al.   AIDS