The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease

Gut microbiota dysbiosis-induced activation of the intrarenal renin–angiotensin system is involved in kidney injuries in rat diabetic nephropathy

(2020) Chen-chen Lu et al.   ACTA PHARMACOLOGICA SINICA

Update on Lupus Nephritis: Core Curriculum 2020

(2020) Samir V. Parikh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function

(2020) Lior Lobel et al.   SCIENCE

The influence of the prebiotic gum acacia on the intestinal microbiome composition in rats with experimental chronic kidney disease

(2020) Arun Prasath Lakshmanan et al.   BIOMEDICINE & PHARMACOTHERAPY

QiDiTangShen granules modulated the gut microbiome composition and improved bile acid profiles in a mouse model of diabetic nephropathy

(2020) Huili Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal

(2019) Doua Azzouz et al.   ANNALS OF THE RHEUMATIC DISEASES

Understanding the gut–kidney axis among biopsy-proven diabetic nephropathy, type 2 diabetes mellitus and healthy controls: an analysis of the gut microbiota composition

(2019) Sibei Tao et al.   ACTA DIABETOLOGICA

The effect of probiotic and synbiotic supplementation on biomarkers of inflammation and oxidative stress in diabetic patients: A systematic review and meta-analysis of randomized controlled trials

(2019) Hui Juan Zheng et al.   PHARMACOLOGICAL RESEARCH

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

(2019) Koichi Kikuchi et al.   Nature Communications

Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice

(2019) Yuchen Feng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Magnesium lithospermate B improves the gut microbiome and bile acid metabolic profiles in a mouse model of diabetic nephropathy

(2018) Jing Zhao et al.   ACTA PHARMACOLOGICA SINICA

Update on Diabetic Nephropathy: Core Curriculum 2018

(2018) Kausik Umanath et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Molecular (Me)micry?

(2018) Orly Avni et al.   Cell Host & Microbe

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

(2018) Teri M. Greiling et al.   Science Translational Medicine

Intestinal Barrier Function in Chronic Kidney Disease

(2018) Björn Meijers et al.   Toxins

New insights into the role of renal resident cells in the pathogenesis of lupus nephritis

(2018) Seung-Ki Kwok et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

An insight into gut microbiota and its functionalities

(2018) Atanu Adak et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shared gut, but distinct oral microbiota composition in primary Sjögren's syndrome and systemic lupus erythematosus

(2018) Taco A. van der Meulen et al.   JOURNAL OF AUTOIMMUNITY

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study

(2018) Tommi Vatanen et al.   NATURE

Intestinal dysbiosis and probiotic applications in autoimmune diseases

(2017) Gislane Lelis Vilela de Oliveira et al.   IMMUNOLOGY

The mucosal barrier at a glance

(2017) Marion M. France et al.   JOURNAL OF CELL SCIENCE

Tolerogenic probiotics: potential immunoregulators in Systemic Lupus Erythematosus

(2017) Seyed-Alireza Esmaeili et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy

(2017) Adeera Levin et al.   LANCET

Gut microbiome in chronic kidney disease: challenges and opportunities

(2017) Anitha Nallu et al.   Translational Research

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Control of lupus nephritis by changes of gut microbiota

(2017) Qinghui Mu et al.   Microbiome

Characterization of two polyvalent phages infecting Enterobacteriaceae

(2017) Sana Hamdi et al.   Scientific Reports

Role of the Gut Microbiome in Uremia: A Potential Therapeutic Target

(2016) Ali Ramezani et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hypertension-Linked Pathophysiological Alterations in the GutNovelty and Significance

(2016) Monica M. Santisteban et al.   CIRCULATION RESEARCH

Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial

(2016) M. Rossi et al.   Clinical Journal of the American Society of Nephrology

Intestinal dysbiosis in systemic lupus erythematosus

(2016) Patricia López et al.   CURRENT OPINION IN RHEUMATOLOGY

Current and Emerging Therapies for Lupus Nephritis

(2016) S. V. Parikh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Depletion of Gut Microbiota Protects against Renal Ischemia-Reperfusion Injury

(2016) Diba Emal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD–Related Systemic Inflammation

(2016) Kirstin Andersen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43

(2016) W Wu et al.   Mucosal Immunology

Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice

(2016) J-Y Yang et al.   Mucosal Immunology

Persistent microbiome alterations modulate the rate of post-dieting weight regain

(2016) Christoph A. Thaiss et al.   NATURE

How the microbiota shapes rheumatic diseases

(2016) Tom Van de Wiele et al.   Nature Reviews Rheumatology

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Alterations of the gut microbiome in Chinese patients with systemic lupus erythematosus

(2016) Zhixing He et al.   Gut Pathogens

The Investigation of the Oxidative Stress-Related Parameters in Type 2 Diabetes Mellitus

(2015) Ouassila Aouacheri et al.   Canadian Journal of Diabetes

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Impact of dietary deviation on disease progression and gut microbiome composition in lupus-prone SNF1mice

(2015) B. M. Johnson et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Commensal microbiota influence systemic autoimmune responses

(2015) J. T. Van Praet et al.   EMBO JOURNAL

Intestinal deletion ofClaudin-7enhances paracellular organic solute flux and initiates colonic inflammation in mice

(2015) Hiroo Tanaka et al.   GUT

Attenuated portal hypertension in germ-free mice: Function of bacterial flora on the development of mesenteric lymphatic and blood vessels

(2015) Sheida Moghadamrad et al.   HEPATOLOGY

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

(2015) David J. Durgan et al.   HYPERTENSION

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Impact of antibiotics on arterial blood pressure in a patient with resistant hypertension — A case report

(2015) YanFei Qi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

(2015) George L. Bakris et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Salivary Microbiota Associated with Immunoglobulin A Nephropathy

(2015) Maria Piccolo et al.   MICROBIAL ECOLOGY

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

The mucosa–kidney axis in IgA nephropathy

(2015) Jürgen Floege et al.   Nature Reviews Nephrology

Altered intestinal microbial flora and impaired epithelial barrier structure and function in CKD: the nature, mechanisms, consequences and potential treatment

(2015) Nosratola D. Vaziri et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting gut microbiota as a possible therapy for diabetes

(2015) Canxia He et al.   NUTRITION RESEARCH

Evidence for a link between gut microbiota and hypertension in the Dahl rat

(2015) Blair Mell et al.   PHYSIOLOGICAL GENOMICS

Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus faecium from the Intestinal Epithelium

(2015) A. P. A. Hendrickx et al.   mBio

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Inflammatory Cytokines in Diabetic Nephropathy

(2015) Javier Donate-Correa et al.   Journal of Diabetes Research

The Parasitic Worm Product ES-62 Targets Myeloid Differentiation Factor 88-Dependent Effector Mechanisms to Suppress Antinuclear Antibody Production and Proteinuria in MRL/lprMice

(2015) David T. Rodgers et al.   Arthritis & Rheumatology

Disturbed T Cell Signaling and Altered Th17 and Regulatory T Cell Subsets in the Pathogenesis of Systemic Lupus Erythematosus

(2015) Nils Rother et al.   Frontiers in Immunology

Bacteriophage therapy against Enterobacteriaceae

(2015) Youqiang Xu et al.   VIROLOGICA SINICA

Expansion of Urease- and Uricase-Containing, Indole- and p-Cresol-Forming and Contraction of Short-Chain Fatty Acid-Producing Intestinal Microbiota in ESRD

(2014) Jakk Wong et al.   AMERICAN JOURNAL OF NEPHROLOGY

Dynamics of Gut Microbiota in Autoimmune Lupus

(2014) Husen Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: Ethnic differences and potential new targets for therapeutic drugs

(2014) Beverly D. Lyn-Cook et al.   MOLECULAR IMMUNOLOGY

Systemic lupus erythematosus and lupus nephritis

(2014) Toli Koutsokeras et al.   NATURE REVIEWS DRUG DISCOVERY

Alterations of intestinal barrier and microbiota in chronic kidney disease

(2014) A. Sabatino et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Microbiota and Metabolome Associated with Immunoglobulin A Nephropathy (IgAN)

(2014) Maria De Angelis et al.   PLoS One

Ischemia-reperfusion: From cell biology to acute kidney injury

(2014) N. Chatauret et al.   PROGRES EN UROLOGIE

Outcomes of stage 1–5 chronic kidney disease in Mainland China

(2014) Xuan Lai et al.   RENAL FAILURE

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

(2014) A. Hevia et al.   mBio

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

(2013) M. A. Croxen et al.   CLINICAL MICROBIOLOGY REVIEWS

Diagnosis and Classification of Diabetes Mellitus

(2013)   DIABETES CARE

The Gut Microbiome, Kidney Disease, and Targeted Interventions

(2013) A. Ramezani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease

(2013) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry

(2013) Hiroki Fujii et al.   Nutrition Journal

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Probiotics as potential biotherapeutics in the management of type 2 diabetes - prospects and perspectives

(2012) Harsh Panwar et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation

(2012) Chiao-Yin Sun et al.   KIDNEY INTERNATIONAL

Chronic kidney disease alters intestinal microbial flora

(2012) Nosratola D. Vaziri et al.   KIDNEY INTERNATIONAL

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Renal Function in Type 2 Diabetes with Rosiglitazone, Metformin, and Glyburide Monotherapy

(2011) J. M. Lachin et al.   Clinical Journal of the American Society of Nephrology

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Mice overexpressing BAFF develop a commensal flora–dependent, IgA-associated nephropathy

(2011) Douglas D. McCarthy et al.   JOURNAL OF CLINICAL INVESTIGATION

Colonic Contribution to Uremic Solutes

(2011) P. A. Aronov et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Albumin-binding capacity (ABiC) is reduced in patients with chronic kidney disease along with an accumulation of protein-bound uraemic toxins

(2011) S. Klammt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Leaky gut and diabetes mellitus: what is the link?

(2011) S. de Kort et al.   Obesity Reviews

Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: A randomized, double-blind and placebo-controlled study

(2011) Parviz Khajehdehi et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Pilot study of probiotic dietary supplementation for promoting healthy kidney function in patients with chronic kidney disease

(2010) Natarajan Ranganathan et al.   ADVANCES IN THERAPY

Adaptive Immune Regulation in the Gut: T Cell–Dependent and T Cell–Independent IgA Synthesis

(2010) Sidonia Fagarasan et al.   Annual Review of Immunology

Circulating Endotoxemia: A Novel Factor in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

(2010) C. W. McIntyre et al.   Clinical Journal of the American Society of Nephrology

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lymphotoxin Beta Receptor Signaling in Intestinal Epithelial Cells Orchestrates Innate Immune Responses against Mucosal Bacterial Infection

(2010) Yugang Wang et al.   IMMUNITY

Function of Mucosa-Associated Lymphoid Tissue in Antibody Formation

(2010) Per Brandtzaeg   IMMUNOLOGICAL INVESTIGATIONS

Stage IV Chronic Kidney Disease

(2010) Hanna Abboud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients

(2010) Federica Capolunghi et al.   RHEUMATOLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Reciprocal Interactions between Commensal Bacteria and    Intraepithelial Lymphocytes during Mucosal Injury

(2009) A. S. Ismail et al.   JOURNAL OF IMMUNOLOGY

The interaction between ischemia–reperfusion and immune responses in the kidney

(2009) Hye Ryoun Jang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Hypertension and CKD: Kidney Early Evaluation Program (KEEP) and National Health and Nutrition Examination Survey (NHANES), 1999-2004

(2008) Madhav V. Rao et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

External suppression causes the low expression of the Cosmc gene in IgA nephropathy

(2008) W. Qin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION